| Full name: ubiquitin specific peptidase 25 | Alias Symbol: USP21 | ||
| Type: protein-coding gene | Cytoband: 21q21.1 | ||
| Entrez ID: 29761 | HGNC ID: HGNC:12624 | Ensembl Gene: ENSG00000155313 | OMIM ID: 604736 |
| Drug and gene relationship at DGIdb | |||
Expression of USP25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP25 | 29761 | 220419_s_at | -0.6718 | 0.0902 | |
| GSE20347 | USP25 | 29761 | 220419_s_at | -1.0592 | 0.0000 | |
| GSE23400 | USP25 | 29761 | 220419_s_at | -0.4814 | 0.0000 | |
| GSE26886 | USP25 | 29761 | 220419_s_at | -1.1929 | 0.0005 | |
| GSE29001 | USP25 | 29761 | 220419_s_at | -0.4366 | 0.1996 | |
| GSE38129 | USP25 | 29761 | 220419_s_at | -0.8946 | 0.0000 | |
| GSE45670 | USP25 | 29761 | 220419_s_at | -0.6764 | 0.0049 | |
| GSE53622 | USP25 | 29761 | 43469 | -0.8507 | 0.0000 | |
| GSE53624 | USP25 | 29761 | 43469 | -0.8168 | 0.0000 | |
| GSE63941 | USP25 | 29761 | 220419_s_at | -0.5010 | 0.5105 | |
| GSE77861 | USP25 | 29761 | 220419_s_at | -0.9591 | 0.0030 | |
| GSE97050 | USP25 | 29761 | A_24_P139208 | -0.2184 | 0.4490 | |
| SRP007169 | USP25 | 29761 | RNAseq | -1.8998 | 0.0002 | |
| SRP008496 | USP25 | 29761 | RNAseq | -1.3517 | 0.0001 | |
| SRP064894 | USP25 | 29761 | RNAseq | -0.7019 | 0.0134 | |
| SRP133303 | USP25 | 29761 | RNAseq | -0.6426 | 0.0027 | |
| SRP159526 | USP25 | 29761 | RNAseq | -0.9513 | 0.0361 | |
| SRP193095 | USP25 | 29761 | RNAseq | -0.9449 | 0.0000 | |
| SRP219564 | USP25 | 29761 | RNAseq | -0.7694 | 0.0196 | |
| TCGA | USP25 | 29761 | RNAseq | -0.1845 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by USP25 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP25 | 29761 | 2 | 9 | 19 | |
| GSE20123 | USP25 | 29761 | 2 | 9 | 19 | |
| GSE43470 | USP25 | 29761 | 2 | 11 | 30 | |
| GSE46452 | USP25 | 29761 | 1 | 22 | 36 | |
| GSE47630 | USP25 | 29761 | 6 | 17 | 17 | |
| GSE54993 | USP25 | 29761 | 9 | 1 | 60 | |
| GSE54994 | USP25 | 29761 | 3 | 10 | 40 | |
| GSE60625 | USP25 | 29761 | 0 | 0 | 11 | |
| GSE74703 | USP25 | 29761 | 2 | 8 | 26 | |
| GSE74704 | USP25 | 29761 | 2 | 6 | 12 | |
| TCGA | USP25 | 29761 | 13 | 39 | 44 |
Total number of gains: 42; Total number of losses: 132; Total Number of normals: 314.
Somatic mutations of USP25:
Generating mutation plots.
Highly correlated genes for USP25:
Showing top 20/1424 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP25 | NDUFB8 | 0.795456 | 3 | 0 | 3 |
| USP25 | FBXL3 | 0.779649 | 4 | 0 | 4 |
| USP25 | ESYT2 | 0.771456 | 4 | 0 | 4 |
| USP25 | MBLAC2 | 0.766362 | 4 | 0 | 4 |
| USP25 | NR2C1 | 0.757515 | 3 | 0 | 3 |
| USP25 | GBF1 | 0.744425 | 3 | 0 | 3 |
| USP25 | C9orf85 | 0.742426 | 3 | 0 | 3 |
| USP25 | UBLCP1 | 0.74195 | 3 | 0 | 3 |
| USP25 | RAB5A | 0.739358 | 10 | 0 | 10 |
| USP25 | COMMD1 | 0.73438 | 4 | 0 | 4 |
| USP25 | RNF185 | 0.732212 | 3 | 0 | 3 |
| USP25 | NDUFV3 | 0.731044 | 3 | 0 | 3 |
| USP25 | MNS1 | 0.728372 | 3 | 0 | 3 |
| USP25 | NFIA | 0.724076 | 6 | 0 | 6 |
| USP25 | SLC25A3 | 0.721575 | 3 | 0 | 3 |
| USP25 | MKRN2 | 0.71895 | 9 | 0 | 8 |
| USP25 | UNK | 0.705505 | 4 | 0 | 3 |
| USP25 | ZNF790 | 0.703803 | 3 | 0 | 3 |
| USP25 | FBXL17 | 0.702688 | 5 | 0 | 4 |
| USP25 | ZNF662 | 0.701922 | 6 | 0 | 6 |
For details and further investigation, click here
