| Full name: serine/threonine/tyrosine kinase 1 | Alias Symbol: SuRTK106|DKFZp761P1010|NOK | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 55359 | HGNC ID: HGNC:18889 | Ensembl Gene: ENSG00000060140 | OMIM ID: 611433 |
| Drug and gene relationship at DGIdb | |||
Expression of STYK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STYK1 | 55359 | 220030_at | -0.5338 | 0.6858 | |
| GSE20347 | STYK1 | 55359 | 220030_at | -1.3694 | 0.0000 | |
| GSE23400 | STYK1 | 55359 | 221696_s_at | -0.2335 | 0.0000 | |
| GSE26886 | STYK1 | 55359 | 220030_at | -1.9408 | 0.0022 | |
| GSE29001 | STYK1 | 55359 | 221696_s_at | -0.5236 | 0.0690 | |
| GSE38129 | STYK1 | 55359 | 220030_at | -0.6446 | 0.0759 | |
| GSE45670 | STYK1 | 55359 | 221696_s_at | 0.2434 | 0.2759 | |
| GSE53622 | STYK1 | 55359 | 115456 | -0.6016 | 0.0025 | |
| GSE53624 | STYK1 | 55359 | 115456 | -0.8845 | 0.0000 | |
| GSE63941 | STYK1 | 55359 | 221696_s_at | 0.6229 | 0.2440 | |
| GSE77861 | STYK1 | 55359 | 221696_s_at | -0.2657 | 0.3462 | |
| GSE97050 | STYK1 | 55359 | A_23_P13822 | -0.0396 | 0.9200 | |
| SRP007169 | STYK1 | 55359 | RNAseq | -2.6824 | 0.0000 | |
| SRP064894 | STYK1 | 55359 | RNAseq | -1.7716 | 0.0000 | |
| SRP133303 | STYK1 | 55359 | RNAseq | -0.4435 | 0.2184 | |
| SRP159526 | STYK1 | 55359 | RNAseq | -1.5299 | 0.0022 | |
| SRP193095 | STYK1 | 55359 | RNAseq | -1.4565 | 0.0000 | |
| SRP219564 | STYK1 | 55359 | RNAseq | -2.0362 | 0.0306 | |
| TCGA | STYK1 | 55359 | RNAseq | -0.1961 | 0.1940 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by STYK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STYK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STYK1 | 55359 | 6 | 2 | 22 | |
| GSE20123 | STYK1 | 55359 | 6 | 2 | 22 | |
| GSE43470 | STYK1 | 55359 | 9 | 3 | 31 | |
| GSE46452 | STYK1 | 55359 | 10 | 1 | 48 | |
| GSE47630 | STYK1 | 55359 | 14 | 2 | 24 | |
| GSE54993 | STYK1 | 55359 | 1 | 10 | 59 | |
| GSE54994 | STYK1 | 55359 | 9 | 2 | 42 | |
| GSE60625 | STYK1 | 55359 | 0 | 1 | 10 | |
| GSE74703 | STYK1 | 55359 | 9 | 2 | 25 | |
| GSE74704 | STYK1 | 55359 | 4 | 1 | 15 | |
| TCGA | STYK1 | 55359 | 39 | 6 | 51 |
Total number of gains: 107; Total number of losses: 32; Total Number of normals: 349.
Somatic mutations of STYK1:
Generating mutation plots.
Highly correlated genes for STYK1:
Showing top 20/981 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STYK1 | KIF21A | 0.738689 | 3 | 0 | 3 |
| STYK1 | NIPAL1 | 0.719181 | 3 | 0 | 3 |
| STYK1 | ARHGAP32 | 0.701408 | 10 | 0 | 10 |
| STYK1 | SERTAD4 | 0.697985 | 3 | 0 | 3 |
| STYK1 | TTC9 | 0.691755 | 10 | 0 | 9 |
| STYK1 | BSPRY | 0.689283 | 10 | 0 | 9 |
| STYK1 | GRAMD1C | 0.684867 | 12 | 0 | 11 |
| STYK1 | EXPH5 | 0.681144 | 10 | 0 | 10 |
| STYK1 | ZDHHC13 | 0.680381 | 11 | 0 | 9 |
| STYK1 | FAM3B | 0.677432 | 4 | 0 | 4 |
| STYK1 | LIPH | 0.674498 | 7 | 0 | 7 |
| STYK1 | FAM135A | 0.673165 | 6 | 0 | 6 |
| STYK1 | EPN3 | 0.673149 | 10 | 0 | 8 |
| STYK1 | SLC10A5 | 0.672777 | 3 | 0 | 3 |
| STYK1 | CGN | 0.671455 | 8 | 0 | 6 |
| STYK1 | RNFT1 | 0.668775 | 3 | 0 | 3 |
| STYK1 | RETSAT | 0.668406 | 4 | 0 | 3 |
| STYK1 | SLC9A3R1 | 0.66742 | 10 | 0 | 10 |
| STYK1 | FUT3 | 0.666526 | 12 | 0 | 9 |
| STYK1 | DHRS9 | 0.66502 | 10 | 0 | 9 |
For details and further investigation, click here
