| Full name: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Alias Symbol: KIAA1320 | ||
| Type: protein-coding gene | Cytoband: 6q16.3 | ||
| Entrez ID: 57531 | HGNC ID: HGNC:21033 | Ensembl Gene: ENSG00000085382 | OMIM ID: 610876 |
| Drug and gene relationship at DGIdb | |||
Expression of HACE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HACE1 | 57531 | 227471_at | -0.8403 | 0.0336 | |
| GSE26886 | HACE1 | 57531 | 227471_at | -1.4195 | 0.0001 | |
| GSE45670 | HACE1 | 57531 | 227471_at | -0.5624 | 0.0019 | |
| GSE53622 | HACE1 | 57531 | 19649 | -0.7243 | 0.0000 | |
| GSE53624 | HACE1 | 57531 | 19649 | -0.7941 | 0.0000 | |
| GSE63941 | HACE1 | 57531 | 227471_at | -0.8319 | 0.0431 | |
| GSE77861 | HACE1 | 57531 | 227471_at | -0.6316 | 0.0258 | |
| GSE97050 | HACE1 | 57531 | A_23_P250002 | -0.1836 | 0.5127 | |
| SRP007169 | HACE1 | 57531 | RNAseq | -0.8531 | 0.0166 | |
| SRP008496 | HACE1 | 57531 | RNAseq | -1.1403 | 0.0000 | |
| SRP064894 | HACE1 | 57531 | RNAseq | -0.7271 | 0.0254 | |
| SRP133303 | HACE1 | 57531 | RNAseq | -0.3620 | 0.0011 | |
| SRP159526 | HACE1 | 57531 | RNAseq | -0.6815 | 0.0302 | |
| SRP193095 | HACE1 | 57531 | RNAseq | -0.6403 | 0.0000 | |
| SRP219564 | HACE1 | 57531 | RNAseq | -0.8839 | 0.0071 | |
| TCGA | HACE1 | 57531 | RNAseq | -0.1211 | 0.0497 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HACE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HACE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HACE1 | 57531 | 2 | 3 | 25 | |
| GSE20123 | HACE1 | 57531 | 2 | 2 | 26 | |
| GSE43470 | HACE1 | 57531 | 3 | 1 | 39 | |
| GSE46452 | HACE1 | 57531 | 2 | 11 | 46 | |
| GSE47630 | HACE1 | 57531 | 8 | 5 | 27 | |
| GSE54993 | HACE1 | 57531 | 3 | 2 | 65 | |
| GSE54994 | HACE1 | 57531 | 8 | 8 | 37 | |
| GSE60625 | HACE1 | 57531 | 0 | 2 | 9 | |
| GSE74703 | HACE1 | 57531 | 2 | 1 | 33 | |
| GSE74704 | HACE1 | 57531 | 1 | 0 | 19 | |
| TCGA | HACE1 | 57531 | 6 | 25 | 65 |
Total number of gains: 37; Total number of losses: 60; Total Number of normals: 391.
Somatic mutations of HACE1:
Generating mutation plots.
Highly correlated genes for HACE1:
Showing top 20/516 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HACE1 | SPAG17 | 0.73522 | 4 | 0 | 3 |
| HACE1 | CAB39L | 0.732165 | 6 | 0 | 6 |
| HACE1 | KIAA0232 | 0.727021 | 7 | 0 | 7 |
| HACE1 | FAM214A | 0.718545 | 6 | 0 | 6 |
| HACE1 | PARD6B | 0.712699 | 3 | 0 | 3 |
| HACE1 | TVP23B | 0.709902 | 3 | 0 | 3 |
| HACE1 | SHROOM3 | 0.707659 | 6 | 0 | 6 |
| HACE1 | FLG-AS1 | 0.706725 | 6 | 0 | 6 |
| HACE1 | SH3BGRL2 | 0.704332 | 6 | 0 | 6 |
| HACE1 | SASH1 | 0.70309 | 7 | 0 | 7 |
| HACE1 | CDK19 | 0.699153 | 6 | 0 | 6 |
| HACE1 | RRAGD | 0.699131 | 6 | 0 | 6 |
| HACE1 | PRSS2 | 0.693758 | 4 | 0 | 4 |
| HACE1 | SIM2 | 0.693209 | 6 | 0 | 6 |
| HACE1 | CAPN5 | 0.693133 | 6 | 0 | 6 |
| HACE1 | GABRP | 0.690325 | 4 | 0 | 4 |
| HACE1 | USO1 | 0.68971 | 6 | 0 | 6 |
| HACE1 | USP46 | 0.684534 | 5 | 0 | 5 |
| HACE1 | NUCB2 | 0.68415 | 6 | 0 | 6 |
| HACE1 | EMP1 | 0.675872 | 6 | 0 | 6 |
For details and further investigation, click here
