RPA1

 

Full name: replication protein A1 Alias Symbol: REPA1|RPA70|HSSB|RF-A|RP-A
Type: protein-coding gene Cytoband: 17p13.3
Entrez ID: 6117 HGNC ID: HGNC:10289 Ensembl Gene: ENSG00000132383 OMIM ID: 179835
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RPA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RPA1 6117 201528_at 0.7815 0.0103
GSE20347 RPA1 6117 201528_at 0.7001 0.0002
GSE23400 RPA1 6117 201528_at 0.8482 0.0000
GSE26886 RPA1 6117 201528_at 0.6949 0.0019
GSE29001 RPA1 6117 201528_at 0.7743 0.0014
GSE38129 RPA1 6117 201528_at 0.7053 0.0000
GSE45670 RPA1 6117 201528_at 0.5516 0.0048
GSE53622 RPA1 6117 139090 0.3798 0.0000
GSE53624 RPA1 6117 139090 0.6462 0.0000
GSE63941 RPA1 6117 201528_at 1.3070 0.0012
GSE77861 RPA1 6117 201528_at 0.5938 0.0324
GSE97050 RPA1 6117 A_23_P107073 0.2615 0.3033
SRP007169 RPA1 6117 RNAseq 1.9976 0.0000
SRP008496 RPA1 6117 RNAseq 1.6821 0.0000
SRP064894 RPA1 6117 RNAseq 0.5417 0.0009
SRP133303 RPA1 6117 RNAseq 0.2516 0.1126
SRP159526 RPA1 6117 RNAseq 0.7644 0.0000
SRP193095 RPA1 6117 RNAseq 0.5527 0.0000
SRP219564 RPA1 6117 RNAseq 0.3314 0.2925
TCGA RPA1 6117 RNAseq 0.2037 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by RPA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RPA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RPA1 6117 4 2 24
GSE20123 RPA1 6117 4 3 23
GSE43470 RPA1 6117 3 6 34
GSE46452 RPA1 6117 34 1 24
GSE47630 RPA1 6117 8 1 31
GSE54993 RPA1 6117 9 3 58
GSE54994 RPA1 6117 8 8 37
GSE60625 RPA1 6117 4 0 7
GSE74703 RPA1 6117 2 3 31
GSE74704 RPA1 6117 2 1 17
TCGA RPA1 6117 19 21 56

Total number of gains: 97; Total number of losses: 49; Total Number of normals: 342.  

 

Somatic mutations of RPA1:

 

Generating mutation plots.

 

Highly correlated genes for RPA1:

 

Showing top 20/1806 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RPA1WDR810.781427505
RPA1SYNE20.778383303
RPA1MCM30.76728511011
RPA1CMTM40.746002505
RPA1SLC7A6OS0.744172303
RPA1CRTC20.740298303
RPA1MCM60.73971613012
RPA1ALG10.738918404
RPA1TIMELESS0.73645112012
RPA1SF3B40.728964707
RPA1PTPRF0.728384303
RPA1MMS190.725856303
RPA1FXR10.72499211011
RPA1DHX330.717055807
RPA1PARG0.714938303
RPA1SORL10.712653403
RPA1SNRPE0.71250712011
RPA1DNMT10.71168112012
RPA1STARD70.71143712011
RPA1ECT20.71035812011

For details and further investigation, click here