| Full name: tachykinin receptor 1 | Alias Symbol: SPR|NK1R|NKIR | ||
| Type: protein-coding gene | Cytoband: 2p12 | ||
| Entrez ID: 6869 | HGNC ID: HGNC:11526 | Ensembl Gene: ENSG00000115353 | OMIM ID: 162323 |
| Drug and gene relationship at DGIdb | |||
TACR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of TACR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TACR1 | 6869 | 230908_at | -0.5384 | 0.3911 | |
| GSE20347 | TACR1 | 6869 | 210637_at | 0.0352 | 0.7425 | |
| GSE23400 | TACR1 | 6869 | 210637_at | -0.2353 | 0.0000 | |
| GSE26886 | TACR1 | 6869 | 210637_at | 0.3351 | 0.0506 | |
| GSE29001 | TACR1 | 6869 | 210637_at | -0.2707 | 0.0523 | |
| GSE38129 | TACR1 | 6869 | 208049_s_at | -0.1950 | 0.0005 | |
| GSE45670 | TACR1 | 6869 | 208048_at | -0.0072 | 0.9479 | |
| GSE53622 | TACR1 | 6869 | 75393 | -1.6903 | 0.0000 | |
| GSE53624 | TACR1 | 6869 | 75393 | -1.4659 | 0.0000 | |
| GSE63941 | TACR1 | 6869 | 208049_s_at | -0.0738 | 0.6345 | |
| GSE77861 | TACR1 | 6869 | 210637_at | -0.2388 | 0.2134 | |
| GSE97050 | TACR1 | 6869 | A_24_P148590 | -1.1407 | 0.1215 | |
| SRP064894 | TACR1 | 6869 | RNAseq | -1.7684 | 0.0002 | |
| SRP133303 | TACR1 | 6869 | RNAseq | -1.4039 | 0.0000 | |
| SRP159526 | TACR1 | 6869 | RNAseq | -1.2510 | 0.0879 | |
| SRP193095 | TACR1 | 6869 | RNAseq | -0.2985 | 0.1546 | |
| SRP219564 | TACR1 | 6869 | RNAseq | -1.2501 | 0.1195 | |
| TCGA | TACR1 | 6869 | RNAseq | -1.2222 | 0.0060 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TACR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TACR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TACR1 | 6869 | 9 | 2 | 19 | |
| GSE20123 | TACR1 | 6869 | 9 | 2 | 19 | |
| GSE43470 | TACR1 | 6869 | 4 | 0 | 39 | |
| GSE46452 | TACR1 | 6869 | 2 | 3 | 54 | |
| GSE47630 | TACR1 | 6869 | 7 | 0 | 33 | |
| GSE54993 | TACR1 | 6869 | 0 | 6 | 64 | |
| GSE54994 | TACR1 | 6869 | 10 | 0 | 43 | |
| GSE60625 | TACR1 | 6869 | 0 | 3 | 8 | |
| GSE74703 | TACR1 | 6869 | 4 | 0 | 32 | |
| GSE74704 | TACR1 | 6869 | 8 | 0 | 12 | |
| TCGA | TACR1 | 6869 | 36 | 2 | 58 |
Total number of gains: 89; Total number of losses: 18; Total Number of normals: 381.
Somatic mutations of TACR1:
Generating mutation plots.
Highly correlated genes for TACR1:
Showing top 20/821 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TACR1 | LINC00320 | 0.772289 | 3 | 0 | 3 |
| TACR1 | ASTN1 | 0.727215 | 4 | 0 | 4 |
| TACR1 | DCLK1 | 0.718429 | 3 | 0 | 3 |
| TACR1 | SYT13 | 0.696778 | 3 | 0 | 3 |
| TACR1 | MYZAP | 0.692044 | 3 | 0 | 3 |
| TACR1 | MOV10L1 | 0.686138 | 3 | 0 | 3 |
| TACR1 | NMNAT2 | 0.68586 | 3 | 0 | 3 |
| TACR1 | SFTPB | 0.685675 | 6 | 0 | 5 |
| TACR1 | IL11RA | 0.682503 | 4 | 0 | 4 |
| TACR1 | NAT2 | 0.680636 | 3 | 0 | 3 |
| TACR1 | KRTAP20-1 | 0.679179 | 3 | 0 | 3 |
| TACR1 | EDA2R | 0.67733 | 4 | 0 | 4 |
| TACR1 | MPL | 0.669234 | 5 | 0 | 5 |
| TACR1 | RNF208 | 0.665485 | 7 | 0 | 5 |
| TACR1 | BOK | 0.664623 | 5 | 0 | 4 |
| TACR1 | KCNC1 | 0.656297 | 4 | 0 | 4 |
| TACR1 | ATRNL1 | 0.654838 | 6 | 0 | 5 |
| TACR1 | PLEKHN1 | 0.652245 | 4 | 0 | 4 |
| TACR1 | BHLHE23 | 0.652075 | 4 | 0 | 3 |
| TACR1 | BTBD19 | 0.649558 | 4 | 0 | 3 |
For details and further investigation, click here
