| Full name: BCL2 family apoptosis regulator BOK | Alias Symbol: BCL2L9|BOKL|MGC4631 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 666 | HGNC ID: HGNC:1087 | Ensembl Gene: ENSG00000176720 | OMIM ID: 605404 |
| Drug and gene relationship at DGIdb | |||
Expression of BOK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BOK | 666 | 223349_s_at | -0.5739 | 0.1126 | |
| GSE26886 | BOK | 666 | 223349_s_at | -1.0203 | 0.0000 | |
| GSE45670 | BOK | 666 | 223349_s_at | -0.0793 | 0.7017 | |
| GSE53622 | BOK | 666 | 39530 | -3.1187 | 0.0000 | |
| GSE53624 | BOK | 666 | 39530 | -3.5704 | 0.0000 | |
| GSE63941 | BOK | 666 | 223349_s_at | -0.4831 | 0.4422 | |
| GSE77861 | BOK | 666 | 223349_s_at | -0.1904 | 0.6193 | |
| GSE97050 | BOK | 666 | A_23_P253029 | -1.6044 | 0.0844 | |
| SRP007169 | BOK | 666 | RNAseq | -1.3165 | 0.0031 | |
| SRP008496 | BOK | 666 | RNAseq | -1.2998 | 0.0000 | |
| SRP064894 | BOK | 666 | RNAseq | 0.0027 | 0.9935 | |
| SRP133303 | BOK | 666 | RNAseq | -0.6489 | 0.0010 | |
| SRP159526 | BOK | 666 | RNAseq | -0.9782 | 0.0001 | |
| SRP193095 | BOK | 666 | RNAseq | -0.6251 | 0.0006 | |
| SRP219564 | BOK | 666 | RNAseq | -0.9166 | 0.0084 | |
| TCGA | BOK | 666 | RNAseq | -0.1730 | 0.0224 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by BOK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BOK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BOK | 666 | 1 | 12 | 17 | |
| GSE20123 | BOK | 666 | 1 | 12 | 17 | |
| GSE43470 | BOK | 666 | 1 | 9 | 33 | |
| GSE46452 | BOK | 666 | 0 | 5 | 54 | |
| GSE47630 | BOK | 666 | 4 | 5 | 31 | |
| GSE54993 | BOK | 666 | 4 | 3 | 63 | |
| GSE54994 | BOK | 666 | 8 | 9 | 36 | |
| GSE60625 | BOK | 666 | 0 | 3 | 8 | |
| GSE74703 | BOK | 666 | 1 | 7 | 28 | |
| GSE74704 | BOK | 666 | 1 | 5 | 14 | |
| TCGA | BOK | 666 | 11 | 29 | 56 |
Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.
Somatic mutations of BOK:
Generating mutation plots.
Highly correlated genes for BOK:
Showing top 20/979 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BOK | ELN | 0.863403 | 3 | 0 | 3 |
| BOK | CRISP3 | 0.831803 | 5 | 0 | 5 |
| BOK | PRAMEF10 | 0.805926 | 4 | 0 | 4 |
| BOK | EMP1 | 0.804167 | 5 | 0 | 5 |
| BOK | TGM3 | 0.799187 | 5 | 0 | 5 |
| BOK | MYZAP | 0.79827 | 3 | 0 | 3 |
| BOK | PHACTR2 | 0.790289 | 5 | 0 | 5 |
| BOK | ABLIM3 | 0.785873 | 4 | 0 | 4 |
| BOK | UPK3B | 0.78261 | 3 | 0 | 3 |
| BOK | SLURP1 | 0.779947 | 5 | 0 | 5 |
| BOK | CASC3 | 0.770521 | 3 | 0 | 3 |
| BOK | UPK1A | 0.766376 | 6 | 0 | 6 |
| BOK | KLK13 | 0.763833 | 5 | 0 | 5 |
| BOK | EPGN | 0.763748 | 3 | 0 | 3 |
| BOK | MAL | 0.762885 | 6 | 0 | 5 |
| BOK | MKNK2 | 0.761406 | 5 | 0 | 5 |
| BOK | B3GNT6 | 0.757696 | 4 | 0 | 4 |
| BOK | MORN3 | 0.75614 | 4 | 0 | 3 |
| BOK | TMPRSS11B | 0.75282 | 6 | 0 | 5 |
| BOK | EPS8L1 | 0.752721 | 6 | 0 | 5 |
For details and further investigation, click here
