| Full name: THAP domain containing 1 | Alias Symbol: FLJ10477|4833431A01Rik | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 55145 | HGNC ID: HGNC:20856 | Ensembl Gene: ENSG00000131931 | OMIM ID: 609520 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of THAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THAP1 | 55145 | 219292_at | -0.0609 | 0.9386 | |
| GSE20347 | THAP1 | 55145 | 219292_at | 0.1285 | 0.5304 | |
| GSE23400 | THAP1 | 55145 | 219292_at | 0.1118 | 0.0155 | |
| GSE26886 | THAP1 | 55145 | 219292_at | -1.0439 | 0.0005 | |
| GSE29001 | THAP1 | 55145 | 219292_at | 0.3854 | 0.3047 | |
| GSE38129 | THAP1 | 55145 | 219292_at | 0.0027 | 0.9896 | |
| GSE45670 | THAP1 | 55145 | 219292_at | 0.1690 | 0.2962 | |
| GSE53622 | THAP1 | 55145 | 25847 | 0.0465 | 0.6735 | |
| GSE53624 | THAP1 | 55145 | 25847 | 0.2832 | 0.0094 | |
| GSE63941 | THAP1 | 55145 | 219292_at | -0.9087 | 0.0371 | |
| GSE77861 | THAP1 | 55145 | 219292_at | -0.0225 | 0.9284 | |
| GSE97050 | THAP1 | 55145 | A_23_P134814 | 0.0669 | 0.7918 | |
| SRP007169 | THAP1 | 55145 | RNAseq | 0.5325 | 0.2785 | |
| SRP008496 | THAP1 | 55145 | RNAseq | 0.2883 | 0.3699 | |
| SRP064894 | THAP1 | 55145 | RNAseq | 0.4149 | 0.0504 | |
| SRP133303 | THAP1 | 55145 | RNAseq | 0.3953 | 0.0083 | |
| SRP159526 | THAP1 | 55145 | RNAseq | 0.0927 | 0.7094 | |
| SRP193095 | THAP1 | 55145 | RNAseq | 0.0141 | 0.9026 | |
| SRP219564 | THAP1 | 55145 | RNAseq | -0.0939 | 0.8252 | |
| TCGA | THAP1 | 55145 | RNAseq | 0.0474 | 0.4602 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by THAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THAP1 | 55145 | 10 | 4 | 16 | |
| GSE20123 | THAP1 | 55145 | 10 | 4 | 16 | |
| GSE43470 | THAP1 | 55145 | 8 | 6 | 29 | |
| GSE46452 | THAP1 | 55145 | 19 | 5 | 35 | |
| GSE47630 | THAP1 | 55145 | 22 | 1 | 17 | |
| GSE54993 | THAP1 | 55145 | 1 | 16 | 53 | |
| GSE54994 | THAP1 | 55145 | 18 | 8 | 27 | |
| GSE60625 | THAP1 | 55145 | 3 | 0 | 8 | |
| GSE74703 | THAP1 | 55145 | 7 | 5 | 24 | |
| GSE74704 | THAP1 | 55145 | 9 | 1 | 10 | |
| TCGA | THAP1 | 55145 | 39 | 21 | 36 |
Total number of gains: 146; Total number of losses: 71; Total Number of normals: 271.
Somatic mutations of THAP1:
Generating mutation plots.
Highly correlated genes for THAP1:
Showing top 20/664 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THAP1 | PLEKHM3 | 0.755506 | 3 | 0 | 3 |
| THAP1 | VPS37A | 0.749161 | 3 | 0 | 3 |
| THAP1 | FBXO3 | 0.74614 | 3 | 0 | 3 |
| THAP1 | DPY19L3 | 0.745303 | 3 | 0 | 3 |
| THAP1 | TMTC3 | 0.740656 | 3 | 0 | 3 |
| THAP1 | ATL1 | 0.737466 | 3 | 0 | 3 |
| THAP1 | NAA25 | 0.73301 | 3 | 0 | 3 |
| THAP1 | KIAA2026 | 0.729522 | 3 | 0 | 3 |
| THAP1 | ZRANB2 | 0.729252 | 3 | 0 | 3 |
| THAP1 | PIK3CB | 0.727212 | 3 | 0 | 3 |
| THAP1 | TSHZ1 | 0.716674 | 3 | 0 | 3 |
| THAP1 | PTAR1 | 0.712623 | 4 | 0 | 4 |
| THAP1 | EXOC2 | 0.709084 | 3 | 0 | 3 |
| THAP1 | RDH14 | 0.708668 | 3 | 0 | 3 |
| THAP1 | TRIP4 | 0.703546 | 3 | 0 | 3 |
| THAP1 | DDX3X | 0.699264 | 3 | 0 | 3 |
| THAP1 | LMBRD2 | 0.697956 | 4 | 0 | 3 |
| THAP1 | HCFC2 | 0.695324 | 3 | 0 | 3 |
| THAP1 | FBXW2 | 0.693737 | 3 | 0 | 3 |
| THAP1 | GLUD2 | 0.692463 | 3 | 0 | 3 |
For details and further investigation, click here
