| Full name: threonine synthase like 1 | Alias Symbol: FLJ22002|TSH1 | ||
| Type: protein-coding gene | Cytoband: 10p12.1 | ||
| Entrez ID: 79896 | HGNC ID: HGNC:26160 | Ensembl Gene: ENSG00000185875 | OMIM ID: 611260 |
| Drug and gene relationship at DGIdb | |||
Expression of THNSL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THNSL1 | 79896 | 222931_s_at | 0.6635 | 0.1369 | |
| GSE20347 | THNSL1 | 79896 | 219800_s_at | 0.5468 | 0.0003 | |
| GSE23400 | THNSL1 | 79896 | 219800_s_at | 0.0954 | 0.0002 | |
| GSE26886 | THNSL1 | 79896 | 222931_s_at | 0.3511 | 0.4734 | |
| GSE29001 | THNSL1 | 79896 | 219800_s_at | 0.5037 | 0.1159 | |
| GSE38129 | THNSL1 | 79896 | 219800_s_at | 0.6562 | 0.0000 | |
| GSE45670 | THNSL1 | 79896 | 222931_s_at | 0.8017 | 0.0021 | |
| GSE53622 | THNSL1 | 79896 | 42254 | 0.4722 | 0.0005 | |
| GSE53624 | THNSL1 | 79896 | 42254 | 0.8171 | 0.0000 | |
| GSE63941 | THNSL1 | 79896 | 222931_s_at | 1.3514 | 0.0388 | |
| GSE77861 | THNSL1 | 79896 | 222931_s_at | 0.1399 | 0.7240 | |
| GSE97050 | THNSL1 | 79896 | A_33_P3331601 | 0.1165 | 0.5731 | |
| SRP007169 | THNSL1 | 79896 | RNAseq | 1.2465 | 0.0343 | |
| SRP008496 | THNSL1 | 79896 | RNAseq | 1.0715 | 0.0017 | |
| SRP064894 | THNSL1 | 79896 | RNAseq | 0.4600 | 0.0394 | |
| SRP133303 | THNSL1 | 79896 | RNAseq | 0.3340 | 0.1740 | |
| SRP159526 | THNSL1 | 79896 | RNAseq | 0.8523 | 0.0285 | |
| SRP193095 | THNSL1 | 79896 | RNAseq | 0.4143 | 0.0062 | |
| SRP219564 | THNSL1 | 79896 | RNAseq | 0.6886 | 0.0535 | |
| TCGA | THNSL1 | 79896 | RNAseq | 0.1491 | 0.3203 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by THNSL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THNSL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THNSL1 | 79896 | 5 | 7 | 18 | |
| GSE20123 | THNSL1 | 79896 | 5 | 6 | 19 | |
| GSE43470 | THNSL1 | 79896 | 4 | 4 | 35 | |
| GSE46452 | THNSL1 | 79896 | 1 | 14 | 44 | |
| GSE47630 | THNSL1 | 79896 | 5 | 15 | 20 | |
| GSE54993 | THNSL1 | 79896 | 9 | 0 | 61 | |
| GSE54994 | THNSL1 | 79896 | 3 | 9 | 41 | |
| GSE60625 | THNSL1 | 79896 | 0 | 0 | 11 | |
| GSE74703 | THNSL1 | 79896 | 3 | 2 | 31 | |
| GSE74704 | THNSL1 | 79896 | 0 | 5 | 15 | |
| TCGA | THNSL1 | 79896 | 18 | 24 | 54 |
Total number of gains: 53; Total number of losses: 86; Total Number of normals: 349.
Somatic mutations of THNSL1:
Generating mutation plots.
Highly correlated genes for THNSL1:
Showing top 20/328 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THNSL1 | DYNC1I1 | 0.680346 | 5 | 0 | 5 |
| THNSL1 | BTBD3 | 0.656986 | 5 | 0 | 5 |
| THNSL1 | DCLRE1A | 0.643784 | 11 | 0 | 9 |
| THNSL1 | SPC24 | 0.642478 | 3 | 0 | 3 |
| THNSL1 | SEPHS1 | 0.64064 | 10 | 0 | 9 |
| THNSL1 | TAF5 | 0.64045 | 8 | 0 | 8 |
| THNSL1 | ZDHHC16 | 0.634372 | 5 | 0 | 3 |
| THNSL1 | ZNF697 | 0.632548 | 3 | 0 | 3 |
| THNSL1 | SOCS5 | 0.631616 | 3 | 0 | 3 |
| THNSL1 | LARP7 | 0.624511 | 4 | 0 | 3 |
| THNSL1 | EARS2 | 0.622774 | 5 | 0 | 5 |
| THNSL1 | FARSA | 0.622107 | 3 | 0 | 3 |
| THNSL1 | ZNF644 | 0.617764 | 3 | 0 | 3 |
| THNSL1 | AVL9 | 0.611669 | 6 | 0 | 4 |
| THNSL1 | UBL7 | 0.609623 | 3 | 0 | 3 |
| THNSL1 | MTOR | 0.605957 | 4 | 0 | 3 |
| THNSL1 | NSL1 | 0.602838 | 6 | 0 | 5 |
| THNSL1 | ATP2C1 | 0.601487 | 8 | 0 | 6 |
| THNSL1 | MCM2 | 0.597082 | 9 | 0 | 7 |
| THNSL1 | FAM200A | 0.597045 | 5 | 0 | 4 |
For details and further investigation, click here
