| Full name: NSL1 component of MIS12 kinetochore complex | Alias Symbol: DC8|DKFZP566O1646|MIS14 | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 25936 | HGNC ID: HGNC:24548 | Ensembl Gene: ENSG00000117697 | OMIM ID: 609174 |
| Drug and gene relationship at DGIdb | |||
Expression of NSL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSL1 | 25936 | 209484_s_at | 0.6907 | 0.0553 | |
| GSE20347 | NSL1 | 25936 | 209484_s_at | 0.8893 | 0.0000 | |
| GSE23400 | NSL1 | 25936 | 209484_s_at | 0.7034 | 0.0000 | |
| GSE26886 | NSL1 | 25936 | 209484_s_at | -0.3162 | 0.1031 | |
| GSE29001 | NSL1 | 25936 | 209484_s_at | 0.9082 | 0.0003 | |
| GSE38129 | NSL1 | 25936 | 209484_s_at | 0.6625 | 0.0000 | |
| GSE45670 | NSL1 | 25936 | 209484_s_at | 0.4191 | 0.0118 | |
| GSE53622 | NSL1 | 25936 | 114234 | 0.6433 | 0.0000 | |
| GSE53624 | NSL1 | 25936 | 114234 | 0.7898 | 0.0000 | |
| GSE63941 | NSL1 | 25936 | 209484_s_at | 0.4443 | 0.3732 | |
| GSE77861 | NSL1 | 25936 | 209484_s_at | 0.8215 | 0.0023 | |
| GSE97050 | NSL1 | 25936 | A_24_P370970 | 0.4482 | 0.1769 | |
| SRP007169 | NSL1 | 25936 | RNAseq | 0.4677 | 0.3272 | |
| SRP008496 | NSL1 | 25936 | RNAseq | 0.8424 | 0.0305 | |
| SRP064894 | NSL1 | 25936 | RNAseq | 0.5927 | 0.0011 | |
| SRP133303 | NSL1 | 25936 | RNAseq | 0.4603 | 0.0014 | |
| SRP159526 | NSL1 | 25936 | RNAseq | 0.9269 | 0.0001 | |
| SRP193095 | NSL1 | 25936 | RNAseq | 0.2041 | 0.0653 | |
| SRP219564 | NSL1 | 25936 | RNAseq | 0.7702 | 0.0161 | |
| TCGA | NSL1 | 25936 | RNAseq | 0.0810 | 0.1572 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NSL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NSL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSL1 | 25936 | 10 | 0 | 20 | |
| GSE20123 | NSL1 | 25936 | 10 | 0 | 20 | |
| GSE43470 | NSL1 | 25936 | 8 | 0 | 35 | |
| GSE46452 | NSL1 | 25936 | 3 | 1 | 55 | |
| GSE47630 | NSL1 | 25936 | 15 | 0 | 25 | |
| GSE54993 | NSL1 | 25936 | 0 | 6 | 64 | |
| GSE54994 | NSL1 | 25936 | 13 | 0 | 40 | |
| GSE60625 | NSL1 | 25936 | 0 | 0 | 11 | |
| GSE74703 | NSL1 | 25936 | 8 | 0 | 28 | |
| GSE74704 | NSL1 | 25936 | 4 | 0 | 16 | |
| TCGA | NSL1 | 25936 | 46 | 3 | 47 |
Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.
Somatic mutations of NSL1:
Generating mutation plots.
Highly correlated genes for NSL1:
Showing top 20/1502 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSL1 | IPO9 | 0.797266 | 7 | 0 | 7 |
| NSL1 | FAM89B | 0.761746 | 3 | 0 | 3 |
| NSL1 | ORAI1 | 0.751462 | 3 | 0 | 3 |
| NSL1 | RPRD1B | 0.751255 | 3 | 0 | 3 |
| NSL1 | ZNF281 | 0.749271 | 9 | 0 | 9 |
| NSL1 | GORAB | 0.745021 | 7 | 0 | 6 |
| NSL1 | PYCR2 | 0.740198 | 3 | 0 | 3 |
| NSL1 | NF1 | 0.740191 | 3 | 0 | 3 |
| NSL1 | SOCS7 | 0.733967 | 4 | 0 | 3 |
| NSL1 | CERS2 | 0.728798 | 8 | 0 | 8 |
| NSL1 | RAB34 | 0.727226 | 3 | 0 | 3 |
| NSL1 | ADAR | 0.725241 | 10 | 0 | 10 |
| NSL1 | AMMECR1L | 0.719775 | 4 | 0 | 3 |
| NSL1 | TMEM63B | 0.718876 | 3 | 0 | 3 |
| NSL1 | NEDD1 | 0.717661 | 6 | 0 | 5 |
| NSL1 | FLVCR1 | 0.717621 | 7 | 0 | 7 |
| NSL1 | U2SURP | 0.715456 | 8 | 0 | 8 |
| NSL1 | MINPP1 | 0.714906 | 10 | 0 | 10 |
| NSL1 | ZNF496 | 0.71444 | 6 | 0 | 5 |
| NSL1 | C1orf198 | 0.713185 | 5 | 0 | 5 |
For details and further investigation, click here
