| Full name: ATPase secretory pathway Ca2+ transporting 1 | Alias Symbol: KIAA1347|ATP2C1A|PMR1|SPCA1 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 27032 | HGNC ID: HGNC:13211 | Ensembl Gene: ENSG00000017260 | OMIM ID: 604384 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ATP2C1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP2C1 | 27032 | 212255_s_at | 1.1968 | 0.0140 | |
| GSE20347 | ATP2C1 | 27032 | 212255_s_at | 1.0137 | 0.0000 | |
| GSE23400 | ATP2C1 | 27032 | 212255_s_at | 0.9298 | 0.0000 | |
| GSE26886 | ATP2C1 | 27032 | 211137_s_at | 0.5864 | 0.0458 | |
| GSE29001 | ATP2C1 | 27032 | 211137_s_at | 0.8968 | 0.0063 | |
| GSE38129 | ATP2C1 | 27032 | 212255_s_at | 1.0914 | 0.0000 | |
| GSE45670 | ATP2C1 | 27032 | 212255_s_at | 0.8575 | 0.0000 | |
| GSE53622 | ATP2C1 | 27032 | 136479 | 1.2943 | 0.0000 | |
| GSE53624 | ATP2C1 | 27032 | 136479 | 0.9859 | 0.0000 | |
| GSE63941 | ATP2C1 | 27032 | 212255_s_at | -0.5882 | 0.1470 | |
| GSE77861 | ATP2C1 | 27032 | 212255_s_at | 0.6613 | 0.0344 | |
| GSE97050 | ATP2C1 | 27032 | A_24_P137376 | 1.4025 | 0.0795 | |
| SRP007169 | ATP2C1 | 27032 | RNAseq | 1.2415 | 0.0001 | |
| SRP008496 | ATP2C1 | 27032 | RNAseq | 1.6250 | 0.0000 | |
| SRP064894 | ATP2C1 | 27032 | RNAseq | 0.7643 | 0.0001 | |
| SRP133303 | ATP2C1 | 27032 | RNAseq | 0.9705 | 0.0000 | |
| SRP159526 | ATP2C1 | 27032 | RNAseq | 0.8934 | 0.0000 | |
| SRP193095 | ATP2C1 | 27032 | RNAseq | 0.8269 | 0.0000 | |
| SRP219564 | ATP2C1 | 27032 | RNAseq | 0.7494 | 0.0130 | |
| TCGA | ATP2C1 | 27032 | RNAseq | 0.1891 | 0.0001 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by ATP2C1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP2C1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP2C1 | 27032 | 16 | 0 | 14 | |
| GSE20123 | ATP2C1 | 27032 | 16 | 0 | 14 | |
| GSE43470 | ATP2C1 | 27032 | 20 | 0 | 23 | |
| GSE46452 | ATP2C1 | 27032 | 15 | 4 | 40 | |
| GSE47630 | ATP2C1 | 27032 | 18 | 3 | 19 | |
| GSE54993 | ATP2C1 | 27032 | 2 | 8 | 60 | |
| GSE54994 | ATP2C1 | 27032 | 32 | 3 | 18 | |
| GSE60625 | ATP2C1 | 27032 | 0 | 6 | 5 | |
| GSE74703 | ATP2C1 | 27032 | 18 | 0 | 18 | |
| GSE74704 | ATP2C1 | 27032 | 12 | 0 | 8 | |
| TCGA | ATP2C1 | 27032 | 59 | 8 | 29 |
Total number of gains: 208; Total number of losses: 32; Total Number of normals: 248.
Somatic mutations of ATP2C1:
Generating mutation plots.
Highly correlated genes for ATP2C1:
Showing top 20/1807 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP2C1 | MTBP | 0.816751 | 5 | 0 | 5 |
| ATP2C1 | TOPBP1 | 0.811933 | 12 | 0 | 12 |
| ATP2C1 | PLXNA1 | 0.78119 | 11 | 0 | 11 |
| ATP2C1 | PYCR2 | 0.78066 | 3 | 0 | 3 |
| ATP2C1 | ACTL6A | 0.778555 | 12 | 0 | 12 |
| ATP2C1 | ATR | 0.778018 | 12 | 0 | 12 |
| ATP2C1 | PIK3R4 | 0.769415 | 12 | 0 | 12 |
| ATP2C1 | U2SURP | 0.768609 | 9 | 0 | 9 |
| ATP2C1 | SLC39A3 | 0.767225 | 3 | 0 | 3 |
| ATP2C1 | PARP14 | 0.766442 | 6 | 0 | 6 |
| ATP2C1 | MMS22L | 0.765978 | 3 | 0 | 3 |
| ATP2C1 | TMEM138 | 0.763368 | 6 | 0 | 6 |
| ATP2C1 | RPN1 | 0.754811 | 11 | 0 | 10 |
| ATP2C1 | DNAJB11 | 0.752425 | 7 | 0 | 6 |
| ATP2C1 | ZIC5 | 0.748478 | 3 | 0 | 3 |
| ATP2C1 | ECT2 | 0.746971 | 12 | 0 | 10 |
| ATP2C1 | CBX3 | 0.745187 | 10 | 0 | 10 |
| ATP2C1 | NEK2 | 0.744658 | 11 | 0 | 10 |
| ATP2C1 | UMPS | 0.744007 | 10 | 0 | 10 |
| ATP2C1 | GORAB | 0.741161 | 6 | 0 | 5 |
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