| Full name: thrombospondin type 1 domain containing 4 | Alias Symbol: FVSY9334|PRO34005|FLJ13710|ADAMTSL6 | ||
| Type: protein-coding gene | Cytoband: 15q23 | ||
| Entrez ID: 79875 | HGNC ID: HGNC:25835 | Ensembl Gene: ENSG00000187720 | OMIM ID: 614476 |
| Drug and gene relationship at DGIdb | |||
Expression of THSD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THSD4 | 79875 | 222835_at | -2.9424 | 0.0086 | |
| GSE20347 | THSD4 | 79875 | 219153_s_at | -0.7885 | 0.0000 | |
| GSE23400 | THSD4 | 79875 | 219153_s_at | -0.5553 | 0.0000 | |
| GSE26886 | THSD4 | 79875 | 222835_at | -2.3801 | 0.0001 | |
| GSE29001 | THSD4 | 79875 | 219153_s_at | -1.2989 | 0.0190 | |
| GSE38129 | THSD4 | 79875 | 219153_s_at | -0.7836 | 0.0000 | |
| GSE45670 | THSD4 | 79875 | 222835_at | -1.2488 | 0.0173 | |
| GSE53622 | THSD4 | 79875 | 113198 | -3.6003 | 0.0000 | |
| GSE53624 | THSD4 | 79875 | 113198 | -4.3877 | 0.0000 | |
| GSE63941 | THSD4 | 79875 | 222835_at | -2.1248 | 0.0240 | |
| GSE77861 | THSD4 | 79875 | 222835_at | -2.3142 | 0.0002 | |
| GSE97050 | THSD4 | 79875 | A_33_P3240693 | -0.9752 | 0.1782 | |
| SRP007169 | THSD4 | 79875 | RNAseq | -1.7247 | 0.0208 | |
| SRP008496 | THSD4 | 79875 | RNAseq | -2.4376 | 0.0000 | |
| SRP064894 | THSD4 | 79875 | RNAseq | -3.1121 | 0.0000 | |
| SRP133303 | THSD4 | 79875 | RNAseq | -2.9529 | 0.0000 | |
| SRP159526 | THSD4 | 79875 | RNAseq | -3.9468 | 0.0000 | |
| SRP193095 | THSD4 | 79875 | RNAseq | -2.5661 | 0.0000 | |
| SRP219564 | THSD4 | 79875 | RNAseq | -2.9810 | 0.0000 | |
| TCGA | THSD4 | 79875 | RNAseq | -0.4495 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by THSD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THSD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THSD4 | 79875 | 7 | 1 | 22 | |
| GSE20123 | THSD4 | 79875 | 7 | 1 | 22 | |
| GSE43470 | THSD4 | 79875 | 4 | 6 | 33 | |
| GSE46452 | THSD4 | 79875 | 3 | 7 | 49 | |
| GSE47630 | THSD4 | 79875 | 8 | 10 | 22 | |
| GSE54993 | THSD4 | 79875 | 5 | 6 | 59 | |
| GSE54994 | THSD4 | 79875 | 6 | 8 | 39 | |
| GSE60625 | THSD4 | 79875 | 4 | 4 | 3 | |
| GSE74703 | THSD4 | 79875 | 4 | 3 | 29 | |
| GSE74704 | THSD4 | 79875 | 3 | 1 | 16 | |
| TCGA | THSD4 | 79875 | 9 | 18 | 69 |
Total number of gains: 60; Total number of losses: 65; Total Number of normals: 363.
Somatic mutations of THSD4:
Generating mutation plots.
Highly correlated genes for THSD4:
Showing top 20/1415 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THSD4 | TEAD3 | 0.851755 | 3 | 0 | 3 |
| THSD4 | CA13 | 0.830497 | 3 | 0 | 3 |
| THSD4 | SLC10A5 | 0.82906 | 3 | 0 | 3 |
| THSD4 | PRSS27 | 0.827996 | 6 | 0 | 6 |
| THSD4 | CYSRT1 | 0.826765 | 6 | 0 | 6 |
| THSD4 | EPGN | 0.825961 | 3 | 0 | 3 |
| THSD4 | FAM3D | 0.821038 | 7 | 0 | 7 |
| THSD4 | KRT78 | 0.813947 | 7 | 0 | 7 |
| THSD4 | C5orf66-AS1 | 0.81031 | 6 | 0 | 6 |
| THSD4 | SPATA19 | 0.80936 | 3 | 0 | 3 |
| THSD4 | UPK3B | 0.806747 | 3 | 0 | 3 |
| THSD4 | FCHO2 | 0.80172 | 7 | 0 | 7 |
| THSD4 | SFTA2 | 0.800405 | 4 | 0 | 4 |
| THSD4 | SH3BGRL2 | 0.797513 | 7 | 0 | 7 |
| THSD4 | NIPAL1 | 0.797148 | 3 | 0 | 3 |
| THSD4 | ULK3 | 0.796376 | 7 | 0 | 7 |
| THSD4 | CASC3 | 0.791136 | 3 | 0 | 3 |
| THSD4 | SPINK7 | 0.790372 | 6 | 0 | 6 |
| THSD4 | ASPG | 0.788532 | 6 | 0 | 6 |
| THSD4 | RAET1E | 0.786832 | 6 | 0 | 6 |
For details and further investigation, click here
