| Full name: glutathione-disulfide reductase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p12 | ||
| Entrez ID: 2936 | HGNC ID: HGNC:4623 | Ensembl Gene: ENSG00000104687 | OMIM ID: 138300 |
| Drug and gene relationship at DGIdb | |||
Expression of GSR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSR | 2936 | 225609_at | 0.4035 | 0.4389 | |
| GSE20347 | GSR | 2936 | 205770_at | 0.5442 | 0.0437 | |
| GSE23400 | GSR | 2936 | 205770_at | 0.3050 | 0.0221 | |
| GSE26886 | GSR | 2936 | 225609_at | 0.7551 | 0.0432 | |
| GSE29001 | GSR | 2936 | 205770_at | -0.3480 | 0.3988 | |
| GSE38129 | GSR | 2936 | 205770_at | 0.4830 | 0.0710 | |
| GSE45670 | GSR | 2936 | 225609_at | 0.4601 | 0.2145 | |
| GSE53622 | GSR | 2936 | 93843 | 0.0612 | 0.5700 | |
| GSE53624 | GSR | 2936 | 93843 | 0.1607 | 0.0509 | |
| GSE63941 | GSR | 2936 | 205770_at | 1.1271 | 0.1777 | |
| GSE77861 | GSR | 2936 | 225609_at | 1.0884 | 0.0357 | |
| GSE97050 | GSR | 2936 | A_23_P146084 | 0.0415 | 0.9074 | |
| SRP007169 | GSR | 2936 | RNAseq | 1.0731 | 0.0176 | |
| SRP008496 | GSR | 2936 | RNAseq | 0.8517 | 0.0127 | |
| SRP064894 | GSR | 2936 | RNAseq | -0.7399 | 0.0037 | |
| SRP133303 | GSR | 2936 | RNAseq | -0.4777 | 0.0517 | |
| SRP159526 | GSR | 2936 | RNAseq | 0.7606 | 0.1678 | |
| SRP193095 | GSR | 2936 | RNAseq | 0.4911 | 0.0662 | |
| SRP219564 | GSR | 2936 | RNAseq | -0.3017 | 0.6238 | |
| TCGA | GSR | 2936 | RNAseq | -0.1207 | 0.3114 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GSR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSR | 2936 | 4 | 10 | 16 | |
| GSE20123 | GSR | 2936 | 4 | 10 | 16 | |
| GSE43470 | GSR | 2936 | 4 | 7 | 32 | |
| GSE46452 | GSR | 2936 | 13 | 13 | 33 | |
| GSE47630 | GSR | 2936 | 10 | 8 | 22 | |
| GSE54993 | GSR | 2936 | 2 | 15 | 53 | |
| GSE54994 | GSR | 2936 | 11 | 15 | 27 | |
| GSE60625 | GSR | 2936 | 3 | 0 | 8 | |
| GSE74703 | GSR | 2936 | 4 | 6 | 26 | |
| GSE74704 | GSR | 2936 | 3 | 7 | 10 | |
| TCGA | GSR | 2936 | 18 | 41 | 37 |
Total number of gains: 76; Total number of losses: 132; Total Number of normals: 280.
Somatic mutations of GSR:
Generating mutation plots.
Highly correlated genes for GSR:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSR | CPSF3 | 0.805448 | 4 | 0 | 4 |
| GSR | RICTOR | 0.783831 | 3 | 0 | 3 |
| GSR | MOGS | 0.783643 | 3 | 0 | 3 |
| GSR | SMCR8 | 0.782274 | 3 | 0 | 3 |
| GSR | EIF2AK4 | 0.781304 | 3 | 0 | 3 |
| GSR | GNB5 | 0.768428 | 3 | 0 | 3 |
| GSR | TPMT | 0.765291 | 3 | 0 | 3 |
| GSR | THUMPD2 | 0.75876 | 3 | 0 | 3 |
| GSR | GPN1 | 0.749309 | 3 | 0 | 3 |
| GSR | NOP58 | 0.745478 | 3 | 0 | 3 |
| GSR | NOL9 | 0.744292 | 3 | 0 | 3 |
| GSR | GSPT1 | 0.738664 | 3 | 0 | 3 |
| GSR | REL | 0.735594 | 3 | 0 | 3 |
| GSR | TMTC3 | 0.732979 | 3 | 0 | 3 |
| GSR | C18orf54 | 0.730072 | 3 | 0 | 3 |
| GSR | ASB7 | 0.729933 | 4 | 0 | 4 |
| GSR | TMEM170A | 0.729588 | 3 | 0 | 3 |
| GSR | ZFYVE27 | 0.727042 | 3 | 0 | 3 |
| GSR | SGTB | 0.726923 | 3 | 0 | 3 |
| GSR | CBL | 0.72476 | 3 | 0 | 3 |
For details and further investigation, click here
