| Full name: pleckstrin | Alias Symbol: P47 | ||
| Type: protein-coding gene | Cytoband: 2p14 | ||
| Entrez ID: 5341 | HGNC ID: HGNC:9070 | Ensembl Gene: ENSG00000115956 | OMIM ID: 173570 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEK | 5341 | 203470_s_at | 0.1929 | 0.8220 | |
| GSE20347 | PLEK | 5341 | 203470_s_at | 0.1373 | 0.2191 | |
| GSE23400 | PLEK | 5341 | 203470_s_at | -0.0572 | 0.1508 | |
| GSE26886 | PLEK | 5341 | 203470_s_at | -0.1461 | 0.5183 | |
| GSE29001 | PLEK | 5341 | 203470_s_at | -0.1784 | 0.2079 | |
| GSE38129 | PLEK | 5341 | 203470_s_at | 0.0840 | 0.5134 | |
| GSE45670 | PLEK | 5341 | 203471_s_at | -0.2301 | 0.5494 | |
| GSE63941 | PLEK | 5341 | 203470_s_at | 0.1222 | 0.4902 | |
| GSE77861 | PLEK | 5341 | 203470_s_at | 0.1878 | 0.2864 | |
| GSE97050 | PLEK | 5341 | A_23_P209678 | 0.9315 | 0.1200 | |
| SRP007169 | PLEK | 5341 | RNAseq | 2.6090 | 0.0025 | |
| SRP008496 | PLEK | 5341 | RNAseq | 2.2328 | 0.0002 | |
| SRP064894 | PLEK | 5341 | RNAseq | 1.4434 | 0.0001 | |
| SRP133303 | PLEK | 5341 | RNAseq | 1.2290 | 0.0000 | |
| SRP159526 | PLEK | 5341 | RNAseq | 0.9899 | 0.2126 | |
| SRP193095 | PLEK | 5341 | RNAseq | 1.7656 | 0.0000 | |
| SRP219564 | PLEK | 5341 | RNAseq | 1.0879 | 0.0629 | |
| TCGA | PLEK | 5341 | RNAseq | 0.3318 | 0.0309 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by PLEK expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PLEK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEK | 5341 | 11 | 0 | 19 | |
| GSE20123 | PLEK | 5341 | 11 | 0 | 19 | |
| GSE43470 | PLEK | 5341 | 6 | 0 | 37 | |
| GSE46452 | PLEK | 5341 | 2 | 3 | 54 | |
| GSE47630 | PLEK | 5341 | 7 | 0 | 33 | |
| GSE54993 | PLEK | 5341 | 0 | 6 | 64 | |
| GSE54994 | PLEK | 5341 | 12 | 0 | 41 | |
| GSE60625 | PLEK | 5341 | 0 | 3 | 8 | |
| GSE74703 | PLEK | 5341 | 6 | 0 | 30 | |
| GSE74704 | PLEK | 5341 | 9 | 0 | 11 | |
| TCGA | PLEK | 5341 | 36 | 2 | 58 |
Total number of gains: 100; Total number of losses: 14; Total Number of normals: 374.
Somatic mutations of PLEK:
Generating mutation plots.
Highly correlated genes for PLEK:
Showing top 20/345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEK | PRTN3 | 0.790976 | 3 | 0 | 3 |
| PLEK | PIK3R5 | 0.787691 | 4 | 0 | 4 |
| PLEK | SRGN | 0.75823 | 5 | 0 | 4 |
| PLEK | GIMAP4 | 0.757785 | 4 | 0 | 4 |
| PLEK | TIE1 | 0.75681 | 3 | 0 | 3 |
| PLEK | PLXNC1 | 0.75438 | 4 | 0 | 4 |
| PLEK | ITGB2 | 0.743132 | 5 | 0 | 5 |
| PLEK | POU2F2 | 0.737287 | 3 | 0 | 3 |
| PLEK | NLGN3 | 0.729841 | 3 | 0 | 3 |
| PLEK | DOC2B | 0.726026 | 3 | 0 | 3 |
| PLEK | CLEC4A | 0.722838 | 5 | 0 | 5 |
| PLEK | TYROBP | 0.717759 | 5 | 0 | 4 |
| PLEK | FCGR2A | 0.707406 | 4 | 0 | 4 |
| PLEK | PIK3AP1 | 0.701816 | 4 | 0 | 3 |
| PLEK | CEACAM21 | 0.701794 | 4 | 0 | 3 |
| PLEK | GPR65 | 0.701598 | 4 | 0 | 3 |
| PLEK | C1orf162 | 0.701186 | 5 | 0 | 5 |
| PLEK | CD163 | 0.698985 | 4 | 0 | 4 |
| PLEK | C1QB | 0.696742 | 4 | 0 | 4 |
| PLEK | PDE6B | 0.692994 | 3 | 0 | 3 |
For details and further investigation, click here
