| Full name: collagen type VIII alpha 1 chain | Alias Symbol: MGC9568 | ||
| Type: protein-coding gene | Cytoband: 3q12.1 | ||
| Entrez ID: 1295 | HGNC ID: HGNC:2215 | Ensembl Gene: ENSG00000144810 | OMIM ID: 120251 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COL8A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL8A1 | 1295 | 226237_at | 0.3351 | 0.7992 | |
| GSE20347 | COL8A1 | 1295 | 214587_at | 0.0447 | 0.4078 | |
| GSE23400 | COL8A1 | 1295 | 221152_at | -0.0299 | 0.2805 | |
| GSE26886 | COL8A1 | 1295 | 226237_at | 2.6371 | 0.0000 | |
| GSE29001 | COL8A1 | 1295 | 221152_at | -0.0123 | 0.9357 | |
| GSE38129 | COL8A1 | 1295 | 214587_at | 0.0831 | 0.2350 | |
| GSE45670 | COL8A1 | 1295 | 226237_at | -1.5178 | 0.0288 | |
| GSE53622 | COL8A1 | 1295 | 17770 | 2.0489 | 0.0000 | |
| GSE53624 | COL8A1 | 1295 | 17770 | 2.0039 | 0.0000 | |
| GSE63941 | COL8A1 | 1295 | 226237_at | -7.3778 | 0.0000 | |
| GSE77861 | COL8A1 | 1295 | 226237_at | 0.3855 | 0.2319 | |
| GSE97050 | COL8A1 | 1295 | A_23_P69030 | 0.7652 | 0.1993 | |
| SRP007169 | COL8A1 | 1295 | RNAseq | 4.0328 | 0.0000 | |
| SRP008496 | COL8A1 | 1295 | RNAseq | 4.7099 | 0.0000 | |
| SRP064894 | COL8A1 | 1295 | RNAseq | 1.3958 | 0.0001 | |
| SRP133303 | COL8A1 | 1295 | RNAseq | 2.0116 | 0.0000 | |
| SRP159526 | COL8A1 | 1295 | RNAseq | 1.7896 | 0.0000 | |
| SRP193095 | COL8A1 | 1295 | RNAseq | 3.0552 | 0.0000 | |
| SRP219564 | COL8A1 | 1295 | RNAseq | 1.1155 | 0.1593 | |
| TCGA | COL8A1 | 1295 | RNAseq | 0.2148 | 0.2570 |
Upregulated datasets: 9; Downregulated datasets: 2.
Survival by COL8A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL8A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL8A1 | 1295 | 18 | 1 | 11 | |
| GSE20123 | COL8A1 | 1295 | 17 | 1 | 12 | |
| GSE43470 | COL8A1 | 1295 | 19 | 1 | 23 | |
| GSE46452 | COL8A1 | 1295 | 12 | 6 | 41 | |
| GSE47630 | COL8A1 | 1295 | 16 | 6 | 18 | |
| GSE54993 | COL8A1 | 1295 | 2 | 5 | 63 | |
| GSE54994 | COL8A1 | 1295 | 27 | 5 | 21 | |
| GSE60625 | COL8A1 | 1295 | 0 | 6 | 5 | |
| GSE74703 | COL8A1 | 1295 | 15 | 1 | 20 | |
| GSE74704 | COL8A1 | 1295 | 14 | 1 | 5 | |
| TCGA | COL8A1 | 1295 | 50 | 9 | 37 |
Total number of gains: 190; Total number of losses: 42; Total Number of normals: 256.
Somatic mutations of COL8A1:
Generating mutation plots.
Highly correlated genes for COL8A1:
Showing top 20/1163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL8A1 | C11orf96 | 0.831167 | 4 | 0 | 4 |
| COL8A1 | AEBP1 | 0.824906 | 10 | 0 | 10 |
| COL8A1 | FNDC1 | 0.81332 | 8 | 0 | 8 |
| COL8A1 | VCAN | 0.810448 | 10 | 0 | 9 |
| COL8A1 | ISLR | 0.805255 | 10 | 0 | 10 |
| COL8A1 | FBN1 | 0.803785 | 8 | 0 | 8 |
| COL8A1 | RAB34 | 0.801614 | 3 | 0 | 3 |
| COL8A1 | FKBP7 | 0.799194 | 7 | 0 | 7 |
| COL8A1 | SPARC | 0.794298 | 10 | 0 | 10 |
| COL8A1 | PCOLCE | 0.794054 | 10 | 0 | 10 |
| COL8A1 | FN1 | 0.793257 | 9 | 0 | 8 |
| COL8A1 | COL6A3 | 0.787344 | 10 | 0 | 10 |
| COL8A1 | COL12A1 | 0.781252 | 9 | 0 | 9 |
| COL8A1 | COL6A1 | 0.779612 | 10 | 0 | 10 |
| COL8A1 | PODN | 0.773968 | 3 | 0 | 3 |
| COL8A1 | ANGPTL2 | 0.771799 | 10 | 0 | 10 |
| COL8A1 | EFEMP2 | 0.769773 | 10 | 0 | 10 |
| COL8A1 | FADS1 | 0.768382 | 3 | 0 | 3 |
| COL8A1 | CHN1 | 0.767839 | 10 | 0 | 10 |
| COL8A1 | CDH11 | 0.760002 | 10 | 0 | 10 |
For details and further investigation, click here
