| Full name: TCDD inducible poly(ADP-ribose) polymerase | Alias Symbol: DKFZP434J214|DKFZp686N0351|DDF1|PARP7|PARP-7|PARP-1|pART14|RM1 | ||
| Type: protein-coding gene | Cytoband: 3q25.31 | ||
| Entrez ID: 25976 | HGNC ID: HGNC:23696 | Ensembl Gene: ENSG00000163659 | OMIM ID: 612480 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TIPARP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIPARP | 25976 | 212665_at | -0.2669 | 0.7590 | |
| GSE20347 | TIPARP | 25976 | 212665_at | -1.0747 | 0.0001 | |
| GSE23400 | TIPARP | 25976 | 212665_at | -0.8120 | 0.0000 | |
| GSE26886 | TIPARP | 25976 | 212665_at | -0.6919 | 0.0631 | |
| GSE29001 | TIPARP | 25976 | 212665_at | -1.2093 | 0.0057 | |
| GSE38129 | TIPARP | 25976 | 212665_at | -0.9994 | 0.0000 | |
| GSE45670 | TIPARP | 25976 | 212665_at | -0.4348 | 0.0578 | |
| GSE53622 | TIPARP | 25976 | 58063 | -0.8810 | 0.0000 | |
| GSE53624 | TIPARP | 25976 | 58063 | -1.0066 | 0.0000 | |
| GSE63941 | TIPARP | 25976 | 212665_at | 0.0953 | 0.8834 | |
| GSE77861 | TIPARP | 25976 | 212665_at | -0.3854 | 0.3069 | |
| GSE97050 | TIPARP | 25976 | A_23_P143845 | -0.2777 | 0.2586 | |
| SRP007169 | TIPARP | 25976 | RNAseq | -1.6460 | 0.0042 | |
| SRP008496 | TIPARP | 25976 | RNAseq | -1.7112 | 0.0000 | |
| SRP064894 | TIPARP | 25976 | RNAseq | -1.2772 | 0.0000 | |
| SRP133303 | TIPARP | 25976 | RNAseq | -0.1731 | 0.5353 | |
| SRP159526 | TIPARP | 25976 | RNAseq | -0.2108 | 0.6278 | |
| SRP193095 | TIPARP | 25976 | RNAseq | -0.3509 | 0.1629 | |
| SRP219564 | TIPARP | 25976 | RNAseq | -0.5403 | 0.3405 | |
| TCGA | TIPARP | 25976 | RNAseq | -0.0468 | 0.5720 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by TIPARP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIPARP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIPARP | 25976 | 21 | 1 | 8 | |
| GSE20123 | TIPARP | 25976 | 21 | 1 | 8 | |
| GSE43470 | TIPARP | 25976 | 23 | 0 | 20 | |
| GSE46452 | TIPARP | 25976 | 18 | 2 | 39 | |
| GSE47630 | TIPARP | 25976 | 19 | 3 | 18 | |
| GSE54993 | TIPARP | 25976 | 1 | 11 | 58 | |
| GSE54994 | TIPARP | 25976 | 38 | 1 | 14 | |
| GSE60625 | TIPARP | 25976 | 0 | 6 | 5 | |
| GSE74703 | TIPARP | 25976 | 20 | 0 | 16 | |
| GSE74704 | TIPARP | 25976 | 14 | 0 | 6 | |
| TCGA | TIPARP | 25976 | 73 | 1 | 22 |
Total number of gains: 248; Total number of losses: 26; Total Number of normals: 214.
Somatic mutations of TIPARP:
Generating mutation plots.
Highly correlated genes for TIPARP:
Showing top 20/685 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIPARP | C9orf47 | 0.715237 | 3 | 0 | 3 |
| TIPARP | C5orf24 | 0.714006 | 3 | 0 | 3 |
| TIPARP | CTNNA3 | 0.710241 | 3 | 0 | 3 |
| TIPARP | HSPA5 | 0.705616 | 3 | 0 | 3 |
| TIPARP | EIF1B | 0.702793 | 3 | 0 | 3 |
| TIPARP | UQCRC2 | 0.695127 | 3 | 0 | 3 |
| TIPARP | ZNF208 | 0.693828 | 3 | 0 | 3 |
| TIPARP | TAX1BP3 | 0.693316 | 3 | 0 | 3 |
| TIPARP | MOB3C | 0.692346 | 3 | 0 | 3 |
| TIPARP | PLK3 | 0.687071 | 8 | 0 | 7 |
| TIPARP | RAB18 | 0.682698 | 3 | 0 | 3 |
| TIPARP | BTBD7 | 0.680671 | 4 | 0 | 3 |
| TIPARP | MAP2K3 | 0.675633 | 3 | 0 | 3 |
| TIPARP | PHYHIPL | 0.674244 | 4 | 0 | 3 |
| TIPARP | AK3 | 0.670458 | 3 | 0 | 3 |
| TIPARP | ZBTB7A | 0.665172 | 4 | 0 | 3 |
| TIPARP | TMEM19 | 0.664768 | 3 | 0 | 3 |
| TIPARP | CLK1 | 0.663177 | 4 | 0 | 3 |
| TIPARP | NUAK2 | 0.662725 | 3 | 0 | 3 |
| TIPARP | METRNL | 0.660665 | 6 | 0 | 5 |
For details and further investigation, click here
