HSPA5

 

Full name: heat shock protein family A (Hsp70) member 5 Alias Symbol: BiP
Type: protein-coding gene Cytoband: 9q33.3
Entrez ID: 3309 HGNC ID: HGNC:5238 Ensembl Gene: ENSG00000044574 OMIM ID: 138120
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of HSPA5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HSPA5 3309 211936_at -0.1584 0.8793
GSE20347 HSPA5 3309 211936_at 0.2157 0.0867
GSE23400 HSPA5 3309 211936_at 0.5569 0.0000
GSE26886 HSPA5 3309 211936_at -0.2485 0.2248
GSE29001 HSPA5 3309 211936_at 0.1026 0.8633
GSE38129 HSPA5 3309 211936_at 0.5430 0.0001
GSE45670 HSPA5 3309 211936_at 0.6657 0.0003
GSE53622 HSPA5 3309 60090 0.1902 0.1077
GSE53624 HSPA5 3309 60090 0.4446 0.0000
GSE63941 HSPA5 3309 211936_at 0.3563 0.3266
GSE77861 HSPA5 3309 211936_at 0.2970 0.1058
GSE97050 HSPA5 3309 A_24_P98411 0.2562 0.2735
SRP007169 HSPA5 3309 RNAseq 0.2316 0.6567
SRP008496 HSPA5 3309 RNAseq 0.6473 0.0814
SRP064894 HSPA5 3309 RNAseq 0.6773 0.0001
SRP133303 HSPA5 3309 RNAseq 1.0927 0.0000
SRP159526 HSPA5 3309 RNAseq 0.7883 0.0134
SRP193095 HSPA5 3309 RNAseq 0.1798 0.2889
SRP219564 HSPA5 3309 RNAseq 1.0948 0.0179
TCGA HSPA5 3309 RNAseq 0.0708 0.0547

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by HSPA5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HSPA5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HSPA5 3309 4 8 18
GSE20123 HSPA5 3309 4 8 18
GSE43470 HSPA5 3309 5 5 33
GSE46452 HSPA5 3309 6 13 40
GSE47630 HSPA5 3309 3 16 21
GSE54993 HSPA5 3309 3 3 64
GSE54994 HSPA5 3309 12 8 33
GSE60625 HSPA5 3309 0 0 11
GSE74703 HSPA5 3309 5 3 28
GSE74704 HSPA5 3309 2 6 12
TCGA HSPA5 3309 27 25 44

Total number of gains: 71; Total number of losses: 95; Total Number of normals: 322.  

 

Somatic mutations of HSPA5:

 

Generating mutation plots.

 

Highly correlated genes for HSPA5:

 

Showing top 20/597 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HSPA5CDV30.772201303
HSPA5CHD10.75773303
HSPA5MAD2L20.752516303
HSPA5PTPRM0.74328303
HSPA5NXNL20.731454303
HSPA5ITM2C0.730201303
HSPA5BLCAP0.716075303
HSPA5GNB40.706958303
HSPA5TIPARP0.705616303
HSPA5PPP2R5E0.705528303
HSPA5MED100.70346303
HSPA5C12orf430.702846303
HSPA5PUM10.694153303
HSPA5EXOC80.693847303
HSPA5NOL100.690647404
HSPA5BCL60.690007303
HSPA5ANAPC130.688815303
HSPA5G2E30.68791303
HSPA5BTG10.687556403
HSPA5HNRNPC0.686045606

For details and further investigation, click here