MAP2K3

 

Full name: mitogen-activated protein kinase kinase 3 Alias Symbol: MEK3|MKK3|MAPKK3
Type: protein-coding gene Cytoband: 17p11.2
Entrez ID: 5606 HGNC ID: HGNC:6843 Ensembl Gene: ENSG00000034152 OMIM ID: 602315
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MAP2K3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04015Rap1 signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05145Toxoplasmosis
hsa05164Influenza A
hsa05169Epstein-Barr virus infection

 

Expression of MAP2K3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 MAP2K3 5606 52733 -0.4861 0.0000
GSE53624 MAP2K3 5606 52733 -0.5079 0.0000
GSE97050 MAP2K3 5606 A_23_P118427 -0.1906 0.4518
SRP007169 MAP2K3 5606 RNAseq -1.3897 0.0115
SRP008496 MAP2K3 5606 RNAseq -1.6342 0.0000
SRP064894 MAP2K3 5606 RNAseq -0.7661 0.0007
SRP133303 MAP2K3 5606 RNAseq -0.4491 0.0006
SRP159526 MAP2K3 5606 RNAseq -0.7004 0.0259
SRP193095 MAP2K3 5606 RNAseq -0.5144 0.0039
SRP219564 MAP2K3 5606 RNAseq -0.2515 0.4296
TCGA MAP2K3 5606 RNAseq -0.1192 0.0264

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by MAP2K3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP2K3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP2K3 5606 4 5 21
GSE20123 MAP2K3 5606 3 6 21
GSE43470 MAP2K3 5606 1 5 37
GSE46452 MAP2K3 5606 34 1 24
GSE47630 MAP2K3 5606 7 1 32
GSE54993 MAP2K3 5606 2 4 64
GSE54994 MAP2K3 5606 6 6 41
GSE60625 MAP2K3 5606 4 0 7
GSE74703 MAP2K3 5606 1 2 33
GSE74704 MAP2K3 5606 2 2 16
TCGA MAP2K3 5606 18 25 53

Total number of gains: 82; Total number of losses: 57; Total Number of normals: 349.  

 

Somatic mutations of MAP2K3:

 

Generating mutation plots.

 

Highly correlated genes for MAP2K3:

 

Showing top 20/113 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP2K3BCL100.746169303
MAP2K3LRRFIP20.746023303
MAP2K3NLRX10.739859303
MAP2K3VPS37B0.73753303
MAP2K3RAB5A0.735765303
MAP2K3COMTD10.735086303
MAP2K3PI4K2A0.734945303
MAP2K3ZBTB7A0.73389303
MAP2K3PLEKHM10.733548303
MAP2K3SERTAD10.731551303
MAP2K3CLTB0.728248303
MAP2K3RABGGTA0.725363303
MAP2K3TOM10.714827303
MAP2K3KCNG20.714351303
MAP2K3SH3GLB10.714333303
MAP2K3SNX330.709943303
MAP2K3CHMP2A0.706312303
MAP2K3MTF10.706141303
MAP2K3TNIP10.704899303
MAP2K3GTF3C10.701576303

For details and further investigation, click here