| Full name: polo like kinase 3 | Alias Symbol: FNK|PRK | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 1263 | HGNC ID: HGNC:2154 | Ensembl Gene: ENSG00000173846 | OMIM ID: 602913 |
| Drug and gene relationship at DGIdb | |||
PLK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa05152 | Tuberculosis |
Expression of PLK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLK3 | 1263 | 204958_at | -0.4139 | 0.6167 | |
| GSE20347 | PLK3 | 1263 | 204958_at | -0.9862 | 0.0000 | |
| GSE23400 | PLK3 | 1263 | 204958_at | -0.8989 | 0.0000 | |
| GSE26886 | PLK3 | 1263 | 204958_at | -1.2878 | 0.0003 | |
| GSE29001 | PLK3 | 1263 | 204958_at | -1.4724 | 0.0000 | |
| GSE38129 | PLK3 | 1263 | 204958_at | -0.7690 | 0.0001 | |
| GSE45670 | PLK3 | 1263 | 204958_at | -0.4239 | 0.0377 | |
| GSE63941 | PLK3 | 1263 | 204958_at | -0.6194 | 0.2544 | |
| GSE77861 | PLK3 | 1263 | 204958_at | -0.5425 | 0.0055 | |
| GSE97050 | PLK3 | 1263 | A_23_P51646 | -0.6096 | 0.1381 | |
| SRP007169 | PLK3 | 1263 | RNAseq | -2.9723 | 0.0000 | |
| SRP008496 | PLK3 | 1263 | RNAseq | -3.1076 | 0.0000 | |
| SRP064894 | PLK3 | 1263 | RNAseq | -1.4690 | 0.0000 | |
| SRP133303 | PLK3 | 1263 | RNAseq | -1.0530 | 0.0000 | |
| SRP159526 | PLK3 | 1263 | RNAseq | -1.4810 | 0.0000 | |
| SRP193095 | PLK3 | 1263 | RNAseq | -0.7293 | 0.0112 | |
| SRP219564 | PLK3 | 1263 | RNAseq | -0.3874 | 0.4920 | |
| TCGA | PLK3 | 1263 | RNAseq | -0.0261 | 0.7761 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PLK3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PLK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLK3 | 1263 | 4 | 3 | 23 | |
| GSE20123 | PLK3 | 1263 | 4 | 2 | 24 | |
| GSE43470 | PLK3 | 1263 | 7 | 2 | 34 | |
| GSE46452 | PLK3 | 1263 | 2 | 1 | 56 | |
| GSE47630 | PLK3 | 1263 | 9 | 3 | 28 | |
| GSE54993 | PLK3 | 1263 | 0 | 1 | 69 | |
| GSE54994 | PLK3 | 1263 | 13 | 2 | 38 | |
| GSE60625 | PLK3 | 1263 | 0 | 0 | 11 | |
| GSE74703 | PLK3 | 1263 | 6 | 1 | 29 | |
| GSE74704 | PLK3 | 1263 | 2 | 0 | 18 | |
| TCGA | PLK3 | 1263 | 13 | 16 | 67 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of PLK3:
Generating mutation plots.
Highly correlated genes for PLK3:
Showing top 20/1061 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLK3 | DUSP5 | 0.764923 | 10 | 0 | 9 |
| PLK3 | ARSG | 0.759642 | 3 | 0 | 3 |
| PLK3 | PUSL1 | 0.743302 | 3 | 0 | 3 |
| PLK3 | ITPKC | 0.738515 | 9 | 0 | 9 |
| PLK3 | SORT1 | 0.734154 | 8 | 0 | 8 |
| PLK3 | PRDM1 | 0.730394 | 7 | 0 | 7 |
| PLK3 | APOB | 0.729275 | 4 | 0 | 3 |
| PLK3 | UBE2F | 0.72789 | 3 | 0 | 3 |
| PLK3 | TRIP10 | 0.724739 | 9 | 0 | 9 |
| PLK3 | PIM1 | 0.722197 | 10 | 0 | 9 |
| PLK3 | NLRX1 | 0.721409 | 7 | 0 | 7 |
| PLK3 | ACAA1 | 0.720501 | 9 | 0 | 8 |
| PLK3 | ACOX1 | 0.718672 | 8 | 0 | 8 |
| PLK3 | CGNL1 | 0.717869 | 4 | 0 | 4 |
| PLK3 | SESN2 | 0.715573 | 5 | 0 | 5 |
| PLK3 | VPS37B | 0.715474 | 9 | 0 | 8 |
| PLK3 | GYS2 | 0.714156 | 8 | 0 | 8 |
| PLK3 | ZNF143 | 0.712428 | 3 | 0 | 3 |
| PLK3 | CCNDBP1 | 0.711512 | 3 | 0 | 3 |
| PLK3 | PDCD6IP | 0.7087 | 9 | 0 | 8 |
For details and further investigation, click here
