| Full name: T cell leukemia homeobox 2 | Alias Symbol: Enx|Tlx2|NCX | ||
| Type: protein-coding gene | Cytoband: 2p13.1 | ||
| Entrez ID: 3196 | HGNC ID: HGNC:5057 | Ensembl Gene: ENSG00000115297 | OMIM ID: 604240 |
| Drug and gene relationship at DGIdb | |||
Expression of TLX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLX2 | 3196 | 211049_at | -0.0949 | 0.7369 | |
| GSE20347 | TLX2 | 3196 | 211049_at | -0.0684 | 0.3386 | |
| GSE23400 | TLX2 | 3196 | 211049_at | -0.0775 | 0.0085 | |
| GSE26886 | TLX2 | 3196 | 211049_at | 0.2314 | 0.1366 | |
| GSE29001 | TLX2 | 3196 | 211049_at | 0.0536 | 0.7634 | |
| GSE38129 | TLX2 | 3196 | 211049_at | -0.1011 | 0.0892 | |
| GSE45670 | TLX2 | 3196 | 211049_at | -0.0003 | 0.9982 | |
| GSE53622 | TLX2 | 3196 | 80327 | 0.5801 | 0.0001 | |
| GSE53624 | TLX2 | 3196 | 80327 | 1.1031 | 0.0000 | |
| GSE63941 | TLX2 | 3196 | 211049_at | 0.0975 | 0.5865 | |
| GSE77861 | TLX2 | 3196 | 211049_at | -0.0157 | 0.9146 | |
| GSE97050 | TLX2 | 3196 | A_23_P389987 | 0.3201 | 0.3217 | |
| SRP159526 | TLX2 | 3196 | RNAseq | 3.9139 | 0.0000 | |
| TCGA | TLX2 | 3196 | RNAseq | 0.8278 | 0.0904 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TLX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLX2 | 3196 | 9 | 2 | 19 | |
| GSE20123 | TLX2 | 3196 | 10 | 2 | 18 | |
| GSE43470 | TLX2 | 3196 | 4 | 0 | 39 | |
| GSE46452 | TLX2 | 3196 | 2 | 3 | 54 | |
| GSE47630 | TLX2 | 3196 | 7 | 0 | 33 | |
| GSE54993 | TLX2 | 3196 | 0 | 6 | 64 | |
| GSE54994 | TLX2 | 3196 | 10 | 0 | 43 | |
| GSE60625 | TLX2 | 3196 | 0 | 3 | 8 | |
| GSE74703 | TLX2 | 3196 | 4 | 0 | 32 | |
| GSE74704 | TLX2 | 3196 | 8 | 0 | 12 | |
| TCGA | TLX2 | 3196 | 37 | 2 | 57 |
Total number of gains: 91; Total number of losses: 18; Total Number of normals: 379.
Somatic mutations of TLX2:
Generating mutation plots.
Highly correlated genes for TLX2:
Showing top 20/304 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLX2 | CCDC114 | 0.695742 | 3 | 0 | 3 |
| TLX2 | ABCC2 | 0.669716 | 3 | 0 | 3 |
| TLX2 | MGAT5B | 0.666295 | 3 | 0 | 3 |
| TLX2 | CLSTN3 | 0.660283 | 3 | 0 | 3 |
| TLX2 | POLM | 0.651315 | 4 | 0 | 4 |
| TLX2 | CLDN14 | 0.649797 | 3 | 0 | 3 |
| TLX2 | USHBP1 | 0.64705 | 3 | 0 | 3 |
| TLX2 | CATSPER3 | 0.641698 | 3 | 0 | 3 |
| TLX2 | TLR6 | 0.641258 | 4 | 0 | 4 |
| TLX2 | KCNA4 | 0.641123 | 3 | 0 | 3 |
| TLX2 | TPO | 0.637614 | 4 | 0 | 4 |
| TLX2 | WDR60 | 0.63702 | 3 | 0 | 3 |
| TLX2 | DNAI1 | 0.632196 | 4 | 0 | 4 |
| TLX2 | KIF17 | 0.631152 | 4 | 0 | 4 |
| TLX2 | RPP25 | 0.631012 | 3 | 0 | 3 |
| TLX2 | FEZF2 | 0.628804 | 3 | 0 | 3 |
| TLX2 | ZNF639 | 0.624599 | 4 | 0 | 3 |
| TLX2 | KCNT1 | 0.622772 | 4 | 0 | 3 |
| TLX2 | EFNB1 | 0.620896 | 5 | 0 | 4 |
| TLX2 | GJA3 | 0.620117 | 5 | 0 | 4 |
For details and further investigation, click here
