ITPR3

 

Full name: inositol 1,4,5-trisphosphate receptor type 3 Alias Symbol: IP3R3
Type: protein-coding gene Cytoband: 6p21.31
Entrez ID: 3710 HGNC ID: HGNC:6182 Ensembl Gene: ENSG00000096433 OMIM ID: 147267
Drug and gene relationship at DGIdb

 

ITPR3 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05205Proteoglycans in cancer

 

Expression of ITPR3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITPR3 3710 201189_s_at 1.4630 0.0086
GSE20347 ITPR3 3710 201189_s_at 1.1203 0.0000
GSE23400 ITPR3 3710 201189_s_at 1.2152 0.0000
GSE26886 ITPR3 3710 201189_s_at 1.0959 0.0000
GSE29001 ITPR3 3710 201189_s_at 0.9512 0.0000
GSE38129 ITPR3 3710 201189_s_at 1.2710 0.0000
GSE45670 ITPR3 3710 201189_s_at 1.0665 0.0001
GSE53622 ITPR3 3710 69614 1.1305 0.0000
GSE53624 ITPR3 3710 69614 1.2001 0.0000
GSE63941 ITPR3 3710 201189_s_at 1.4188 0.0029
GSE77861 ITPR3 3710 201189_s_at 1.4860 0.0006
GSE97050 ITPR3 3710 A_23_P19517 0.8388 0.1433
SRP007169 ITPR3 3710 RNAseq 1.8873 0.0000
SRP008496 ITPR3 3710 RNAseq 1.6229 0.0000
SRP064894 ITPR3 3710 RNAseq 1.1113 0.0000
SRP133303 ITPR3 3710 RNAseq 1.0698 0.0000
SRP159526 ITPR3 3710 RNAseq 0.8478 0.0000
SRP193095 ITPR3 3710 RNAseq 0.8154 0.0008
SRP219564 ITPR3 3710 RNAseq 0.7248 0.1798
TCGA ITPR3 3710 RNAseq 0.0905 0.1261

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by ITPR3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITPR3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITPR3 3710 5 0 25
GSE20123 ITPR3 3710 5 0 25
GSE43470 ITPR3 3710 4 1 38
GSE46452 ITPR3 3710 2 9 48
GSE47630 ITPR3 3710 8 4 28
GSE54993 ITPR3 3710 3 1 66
GSE54994 ITPR3 3710 11 4 38
GSE60625 ITPR3 3710 1 0 10
GSE74703 ITPR3 3710 4 0 32
GSE74704 ITPR3 3710 2 0 18
TCGA ITPR3 3710 15 16 65

Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.  

 

Somatic mutations of ITPR3:

 

Generating mutation plots.

 

Highly correlated genes for ITPR3:

 

Showing top 20/2127 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITPR3CD2760.816514404
ITPR3FAM89A0.803124303
ITPR3UCK20.786243303
ITPR3PLAU0.77847411011
ITPR3BLM0.77590212012
ITPR3CEP550.77524111010
ITPR3GMNN0.77477512011
ITPR3FANCI0.77375412012
ITPR3UBE2T0.772531808
ITPR3C12orf570.767069303
ITPR3MRPL470.766721707
ITPR3KIF140.76599512012
ITPR3IGF2BP20.76270811011
ITPR3ACLY0.76219711011
ITPR3MRPS50.760412303
ITPR3CENPF0.75964612012
ITPR3CCDC860.756458808
ITPR3LARS20.755349303
ITPR3CCT50.755123808
ITPR3TPX20.75501312012

For details and further investigation, click here