| Full name: protein tyrosine phosphatase non-receptor type 12 | Alias Symbol: PTPG1|PTP-PEST | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 5782 | HGNC ID: HGNC:9645 | Ensembl Gene: ENSG00000127947 | OMIM ID: 600079 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PTPN12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN12 | 5782 | 202006_at | 0.0107 | 0.9891 | |
| GSE20347 | PTPN12 | 5782 | 202006_at | 0.2197 | 0.4374 | |
| GSE23400 | PTPN12 | 5782 | 202006_at | 0.2792 | 0.0072 | |
| GSE26886 | PTPN12 | 5782 | 202006_at | 0.3148 | 0.1881 | |
| GSE29001 | PTPN12 | 5782 | 202006_at | 0.1411 | 0.7563 | |
| GSE38129 | PTPN12 | 5782 | 202006_at | 0.3281 | 0.0477 | |
| GSE45670 | PTPN12 | 5782 | 202006_at | 0.2126 | 0.3848 | |
| GSE53622 | PTPN12 | 5782 | 38696 | 0.4073 | 0.0000 | |
| GSE53624 | PTPN12 | 5782 | 100641 | 0.2007 | 0.0485 | |
| GSE63941 | PTPN12 | 5782 | 202006_at | -0.1519 | 0.7255 | |
| GSE77861 | PTPN12 | 5782 | 202006_at | 0.6435 | 0.0143 | |
| GSE97050 | PTPN12 | 5782 | A_23_P8763 | 0.1346 | 0.6126 | |
| SRP007169 | PTPN12 | 5782 | RNAseq | 0.6745 | 0.0605 | |
| SRP008496 | PTPN12 | 5782 | RNAseq | 0.8873 | 0.0000 | |
| SRP064894 | PTPN12 | 5782 | RNAseq | 0.3107 | 0.2614 | |
| SRP133303 | PTPN12 | 5782 | RNAseq | 0.5370 | 0.0357 | |
| SRP159526 | PTPN12 | 5782 | RNAseq | 0.0218 | 0.9515 | |
| SRP193095 | PTPN12 | 5782 | RNAseq | 0.4438 | 0.0021 | |
| SRP219564 | PTPN12 | 5782 | RNAseq | 0.4271 | 0.3411 | |
| TCGA | PTPN12 | 5782 | RNAseq | 0.2500 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTPN12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN12 | 5782 | 15 | 1 | 14 | |
| GSE20123 | PTPN12 | 5782 | 14 | 1 | 15 | |
| GSE43470 | PTPN12 | 5782 | 4 | 1 | 38 | |
| GSE46452 | PTPN12 | 5782 | 11 | 0 | 48 | |
| GSE47630 | PTPN12 | 5782 | 7 | 3 | 30 | |
| GSE54993 | PTPN12 | 5782 | 1 | 7 | 62 | |
| GSE54994 | PTPN12 | 5782 | 15 | 3 | 35 | |
| GSE60625 | PTPN12 | 5782 | 0 | 0 | 11 | |
| GSE74703 | PTPN12 | 5782 | 3 | 1 | 32 | |
| GSE74704 | PTPN12 | 5782 | 8 | 1 | 11 | |
| TCGA | PTPN12 | 5782 | 43 | 6 | 47 |
Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.
Somatic mutations of PTPN12:
Generating mutation plots.
Highly correlated genes for PTPN12:
Showing top 20/727 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN12 | VPS37A | 0.829417 | 3 | 0 | 3 |
| PTPN12 | KLHDC2 | 0.779214 | 3 | 0 | 3 |
| PTPN12 | KBTBD6 | 0.747674 | 3 | 0 | 3 |
| PTPN12 | AMPD3 | 0.742926 | 3 | 0 | 3 |
| PTPN12 | ABHD6 | 0.742195 | 3 | 0 | 3 |
| PTPN12 | YIPF4 | 0.737478 | 3 | 0 | 3 |
| PTPN12 | PPM1A | 0.732374 | 3 | 0 | 3 |
| PTPN12 | TMCC3 | 0.726268 | 3 | 0 | 3 |
| PTPN12 | ATG2B | 0.718954 | 3 | 0 | 3 |
| PTPN12 | RTKN | 0.714023 | 4 | 0 | 4 |
| PTPN12 | CRYZ | 0.711945 | 3 | 0 | 3 |
| PTPN12 | SNX14 | 0.71104 | 3 | 0 | 3 |
| PTPN12 | USP40 | 0.707686 | 4 | 0 | 4 |
| PTPN12 | EXOC6B | 0.706316 | 4 | 0 | 4 |
| PTPN12 | GLT8D1 | 0.705681 | 3 | 0 | 3 |
| PTPN12 | NANOS1 | 0.705441 | 3 | 0 | 3 |
| PTPN12 | LPAR3 | 0.700992 | 4 | 0 | 4 |
| PTPN12 | TMEM92 | 0.694578 | 3 | 0 | 3 |
| PTPN12 | TOR1A | 0.693815 | 5 | 0 | 4 |
| PTPN12 | NDC80 | 0.693187 | 3 | 0 | 3 |
For details and further investigation, click here
