| Full name: semaphorin 4D | Alias Symbol: CD100|coll-4|FLJ39737 | ||
| Type: protein-coding gene | Cytoband: 9q22.2 | ||
| Entrez ID: 10507 | HGNC ID: HGNC:10732 | Ensembl Gene: ENSG00000187764 | OMIM ID: 601866 |
| Drug and gene relationship at DGIdb | |||
SEMA4D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA4D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA4D | 10507 | 203528_at | -0.7312 | 0.4896 | |
| GSE20347 | SEMA4D | 10507 | 203528_at | -1.2216 | 0.0000 | |
| GSE23400 | SEMA4D | 10507 | 203528_at | -0.6668 | 0.0000 | |
| GSE26886 | SEMA4D | 10507 | 203528_at | -1.2255 | 0.0001 | |
| GSE29001 | SEMA4D | 10507 | 203528_at | -0.9898 | 0.0130 | |
| GSE38129 | SEMA4D | 10507 | 203528_at | -0.6822 | 0.0039 | |
| GSE45670 | SEMA4D | 10507 | 203528_at | -0.6014 | 0.0212 | |
| GSE53622 | SEMA4D | 10507 | 58626 | -0.6873 | 0.0000 | |
| GSE53624 | SEMA4D | 10507 | 58626 | -1.0164 | 0.0000 | |
| GSE63941 | SEMA4D | 10507 | 203528_at | 1.7678 | 0.0157 | |
| GSE77861 | SEMA4D | 10507 | 203528_at | -0.7176 | 0.0257 | |
| GSE97050 | SEMA4D | 10507 | A_24_P261169 | -0.3052 | 0.6318 | |
| SRP007169 | SEMA4D | 10507 | RNAseq | -0.9166 | 0.0054 | |
| SRP008496 | SEMA4D | 10507 | RNAseq | -0.8924 | 0.0001 | |
| SRP064894 | SEMA4D | 10507 | RNAseq | -1.1796 | 0.0000 | |
| SRP133303 | SEMA4D | 10507 | RNAseq | -1.0921 | 0.0000 | |
| SRP159526 | SEMA4D | 10507 | RNAseq | -0.8422 | 0.0280 | |
| SRP193095 | SEMA4D | 10507 | RNAseq | -0.7064 | 0.0002 | |
| SRP219564 | SEMA4D | 10507 | RNAseq | -1.1127 | 0.0984 | |
| TCGA | SEMA4D | 10507 | RNAseq | -0.0820 | 0.3693 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by SEMA4D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA4D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA4D | 10507 | 5 | 10 | 15 | |
| GSE20123 | SEMA4D | 10507 | 5 | 10 | 15 | |
| GSE43470 | SEMA4D | 10507 | 6 | 3 | 34 | |
| GSE46452 | SEMA4D | 10507 | 6 | 14 | 39 | |
| GSE47630 | SEMA4D | 10507 | 1 | 18 | 21 | |
| GSE54993 | SEMA4D | 10507 | 4 | 2 | 64 | |
| GSE54994 | SEMA4D | 10507 | 7 | 11 | 35 | |
| GSE60625 | SEMA4D | 10507 | 0 | 0 | 11 | |
| GSE74703 | SEMA4D | 10507 | 5 | 3 | 28 | |
| GSE74704 | SEMA4D | 10507 | 3 | 7 | 10 | |
| TCGA | SEMA4D | 10507 | 21 | 24 | 51 |
Total number of gains: 63; Total number of losses: 102; Total Number of normals: 323.
Somatic mutations of SEMA4D:
Generating mutation plots.
Highly correlated genes for SEMA4D:
Showing top 20/1188 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA4D | ARHGAP27 | 0.765569 | 8 | 0 | 8 |
| SEMA4D | NAA35 | 0.759502 | 3 | 0 | 3 |
| SEMA4D | ZNRF1 | 0.749112 | 4 | 0 | 4 |
| SEMA4D | ULK3 | 0.747004 | 7 | 0 | 7 |
| SEMA4D | FAM214A | 0.746967 | 6 | 0 | 6 |
| SEMA4D | TMEM19 | 0.745315 | 3 | 0 | 3 |
| SEMA4D | SPNS2 | 0.732279 | 6 | 0 | 6 |
| SEMA4D | PRPF38A | 0.729747 | 3 | 0 | 3 |
| SEMA4D | NAT1 | 0.726092 | 3 | 0 | 3 |
| SEMA4D | UEVLD | 0.725923 | 3 | 0 | 3 |
| SEMA4D | TMED4 | 0.724526 | 3 | 0 | 3 |
| SEMA4D | ZDHHC21 | 0.720545 | 7 | 0 | 7 |
| SEMA4D | LNX1 | 0.719744 | 7 | 0 | 7 |
| SEMA4D | RASSF5 | 0.719659 | 7 | 0 | 7 |
| SEMA4D | SCNN1B | 0.716698 | 10 | 0 | 10 |
| SEMA4D | SMIM5 | 0.713876 | 7 | 0 | 7 |
| SEMA4D | DDI2 | 0.712919 | 3 | 0 | 3 |
| SEMA4D | ACPP | 0.711666 | 10 | 0 | 10 |
| SEMA4D | FAM3B | 0.710714 | 7 | 0 | 7 |
| SEMA4D | BLNK | 0.709713 | 12 | 0 | 11 |
For details and further investigation, click here
