MRC1

 

Full name: mannose receptor C-type 1 Alias Symbol: CLEC13D|CD206|bA541I19.1|CLEC13DL
Type: protein-coding gene Cytoband: 10p12.33
Entrez ID: 4360 HGNC ID: HGNC:7228 Ensembl Gene: ENSG00000260314 OMIM ID: 153618
Drug and gene relationship at DGIdb

 

MRC1 involved pathways:

KEGG pathway Description View
hsa05152Tuberculosis

 

Expression of MRC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRC1 4360 204438_at -0.8139 0.6076
GSE20347 MRC1 4360 204438_at 0.6467 0.0502
GSE23400 MRC1 4360 204438_at 0.4447 0.0090
GSE26886 MRC1 4360 204438_at 1.0836 0.0355
GSE29001 MRC1 4360 204438_at 0.9083 0.0258
GSE38129 MRC1 4360 204438_at 0.3306 0.4820
GSE45670 MRC1 4360 204438_at -1.5288 0.0085
GSE53622 MRC1 4360 128864 0.0367 0.8919
GSE53624 MRC1 4360 128864 0.4302 0.1332
GSE63941 MRC1 4360 204438_at -0.1238 0.3161
GSE77861 MRC1 4360 204438_at 0.3890 0.0794
GSE97050 MRC1 4360 A_23_P12746 0.4708 0.2501
SRP007169 MRC1 4360 RNAseq 3.2267 0.0000
SRP008496 MRC1 4360 RNAseq 3.4012 0.0000
SRP064894 MRC1 4360 RNAseq 0.6728 0.1092
SRP133303 MRC1 4360 RNAseq 0.5613 0.1083
SRP159526 MRC1 4360 RNAseq 1.3017 0.0578
SRP193095 MRC1 4360 RNAseq 1.3111 0.0006
SRP219564 MRC1 4360 RNAseq 1.4994 0.0659
TCGA MRC1 4360 RNAseq -0.2505 0.2394

Upregulated datasets: 4; Downregulated datasets: 1.  

 

Survival by MRC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRC1 4360 3 8 19
GSE20123 MRC1 4360 3 7 20
GSE43470 MRC1 4360 3 4 36
GSE46452 MRC1 4360 1 14 44
GSE47630 MRC1 4360 5 15 20
GSE54993 MRC1 4360 10 0 60
GSE54994 MRC1 4360 4 9 40
GSE60625 MRC1 4360 0 0 11
GSE74703 MRC1 4360 2 3 31
GSE74704 MRC1 4360 0 6 14
TCGA MRC1 4360 18 26 52

Total number of gains: 49; Total number of losses: 92; Total Number of normals: 347.  

 

Somatic mutations of MRC1:

 

Generating mutation plots.

 

Highly correlated genes for MRC1:

 

Showing top 20/948 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRC1CD1630.82804111011
MRC1MS4A4A0.81793410010
MRC1GPR340.786435505
MRC1CCL30.754596303
MRC1IGDCC40.75325707
MRC1VSIG40.74518110010
MRC1C19orf380.744054303
MRC1MS4A6A0.739333808
MRC1PMP220.73319510010
MRC1PHLDB20.730511303
MRC1TMEM176B0.72852710010
MRC1LRRC250.723667404
MRC1FLI10.721486606
MRC1FBN10.7187731009
MRC1CCL180.7121931009
MRC1ITGAM0.711414808
MRC1GIMAP50.710921303
MRC1DAB20.70880512011
MRC1GPR1410.708703303
MRC1C3AR10.70775710010

For details and further investigation, click here