ITGAM

 

Full name: integrin subunit alpha M Alias Symbol: MAC-1|CD11b
Type: protein-coding gene Cytoband: 16p11.2
Entrez ID: 3684 HGNC ID: HGNC:6149 Ensembl Gene: ENSG00000169896 OMIM ID: 120980
Drug and gene relationship at DGIdb

 

ITGAM involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05140Leishmaniasis
hsa05152Tuberculosis

 

Expression of ITGAM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITGAM 3684 205786_s_at 0.2581 0.8684
GSE26886 ITGAM 3684 205786_s_at 1.0141 0.0144
GSE29001 ITGAM 3684 205786_s_at 0.6862 0.0329
GSE38129 ITGAM 3684 205786_s_at 0.1876 0.3693
GSE45670 ITGAM 3684 205786_s_at -0.5824 0.1617
GSE53622 ITGAM 3684 151178 0.4777 0.0148
GSE53624 ITGAM 3684 151178 0.4517 0.0457
GSE97050 ITGAM 3684 A_23_P124108 0.6125 0.1195
SRP007169 ITGAM 3684 RNAseq 3.7356 0.0001
SRP008496 ITGAM 3684 RNAseq 3.7616 0.0000
SRP064894 ITGAM 3684 RNAseq 1.1910 0.0039
SRP133303 ITGAM 3684 RNAseq 0.5532 0.0308
SRP159526 ITGAM 3684 RNAseq 0.6213 0.2553
SRP193095 ITGAM 3684 RNAseq 1.2396 0.0000
SRP219564 ITGAM 3684 RNAseq 1.4848 0.0505
TCGA ITGAM 3684 RNAseq 0.2817 0.1362

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by ITGAM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITGAM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGAM 3684 4 5 21
GSE20123 ITGAM 3684 4 4 22
GSE43470 ITGAM 3684 3 3 37
GSE46452 ITGAM 3684 38 1 20
GSE47630 ITGAM 3684 11 7 22
GSE54993 ITGAM 3684 2 5 63
GSE54994 ITGAM 3684 5 9 39
GSE60625 ITGAM 3684 4 0 7
GSE74703 ITGAM 3684 3 2 31
GSE74704 ITGAM 3684 2 2 16
TCGA ITGAM 3684 20 10 66

Total number of gains: 96; Total number of losses: 48; Total Number of normals: 344.  

 

Somatic mutations of ITGAM:

 

Generating mutation plots.

 

Highly correlated genes for ITGAM:

 

Showing top 20/949 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGAMC19orf380.80737303
ITGAMGNGT20.796036303
ITGAMRAB39B0.764662303
ITGAMFCGR3A0.764323303
ITGAMGPR1410.757434303
ITGAMSUCNR10.756616404
ITGAMCD1630.750335909
ITGAMCD840.741309707
ITGAMSH2B30.734832908
ITGAMSRGN0.733954909
ITGAMCYBB0.733887808
ITGAMIL2RA0.732668404
ITGAMEBI30.732632404
ITGAMLRRK10.730814303
ITGAMJTB0.727837303
ITGAMCERKL0.725995303
ITGAMTMEM176B0.725542908
ITGAMCD1800.724325505
ITGAMCKAP50.722107303
ITGAMGMPS0.721149303

For details and further investigation, click here