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Multi-Omics Database of ESCC

 

TYROBP

 

Full name: TYRO protein tyrosine kinase binding protein Alias Symbol: DAP12|PLO-SL|KARAP
Type: protein-coding gene Cytoband: 19q13.12
Entrez ID: 7305 HGNC ID: HGNC:12449 Ensembl Gene: ENSG00000011600 OMIM ID: 604142
Drug and gene relationship at DGIdb

 

TYROBP involved pathways:

KEGG pathway Description View
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity

 

Expression of TYROBP:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TYROBP 7305 204122_at 0.6795 0.5353
GSE20347 TYROBP 7305 204122_at 0.4304 0.0537
GSE23400 TYROBP 7305 204122_at 0.8169 0.0000
GSE26886 TYROBP 7305 204122_at 0.5457 0.1811
GSE29001 TYROBP 7305 204122_at 1.1932 0.0108
GSE38129 TYROBP 7305 204122_at 0.6004 0.0389
GSE45670 TYROBP 7305 204122_at -0.1619 0.6973
GSE53622 TYROBP 7305 720 0.7013 0.0000
GSE53624 TYROBP 7305 720 0.9344 0.0000
GSE63941 TYROBP 7305 204122_at 0.0073 0.9664
GSE77861 TYROBP 7305 204122_at 0.3058 0.2569
GSE97050 TYROBP 7305 A_33_P3409062 0.6205 0.1310
SRP007169 TYROBP 7305 RNAseq 2.2603 0.0082
SRP008496 TYROBP 7305 RNAseq 1.8048 0.0007
SRP064894 TYROBP 7305 RNAseq 1.4056 0.0008
SRP133303 TYROBP 7305 RNAseq 0.8982 0.0008
SRP159526 TYROBP 7305 RNAseq 0.5307 0.3560
SRP193095 TYROBP 7305 RNAseq 0.9170 0.0000
SRP219564 TYROBP 7305 RNAseq 1.7559 0.0103
TCGA TYROBP 7305 RNAseq 0.4789 0.0001

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by TYROBP expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TYROBP:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TYROBP 7305 7 4 19
GSE20123 TYROBP 7305 7 3 20
GSE43470 TYROBP 7305 3 7 33
GSE46452 TYROBP 7305 48 1 10
GSE47630 TYROBP 7305 9 5 26
GSE54993 TYROBP 7305 17 3 50
GSE54994 TYROBP 7305 6 9 38
GSE60625 TYROBP 7305 9 0 2
GSE74703 TYROBP 7305 3 4 29
GSE74704 TYROBP 7305 6 1 13
TCGA TYROBP 7305 22 10 64

Total number of gains: 137; Total number of losses: 47; Total Number of normals: 304.  

 

Somatic mutations of TYROBP:

 

Generating mutation plots.

 

Highly correlated genes for TYROBP:

 

Showing top 20/874 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TYROBPC1QB0.89522812012
TYROBPFCER1G0.89295911011
TYROBPC1QA0.86002712012
TYROBPFCGR3A0.835695303
TYROBPCD140.83450512012
TYROBPC1QC0.831917808
TYROBPLAPTM50.8152712012
TYROBPITGB20.81517911011
TYROBPC3AR10.80391911010
TYROBPTFEC0.79728510010
TYROBPCD1630.79085912012
TYROBPAIF10.78375812012
TYROBPPLXNC10.77154410010
TYROBPLCP20.763073909
TYROBPMS4A4A0.7597711010
TYROBPCSF1R0.75924812012
TYROBPCCR10.75846311011
TYROBPRNASE20.755146404
TYROBPFCGR2A0.74884812012
TYROBPST8SIA40.748642505

For details and further investigation, click here