| Full name: methyltransferase like 8 | Alias Symbol: FLJ13984|TIP | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 79828 | HGNC ID: HGNC:25856 | Ensembl Gene: ENSG00000123600 | OMIM ID: 609525 |
| Drug and gene relationship at DGIdb | |||
Expression of METTL8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METTL8 | 79828 | 1554667_s_at | 0.7776 | 0.3460 | |
| GSE20347 | METTL8 | 79828 | 220007_at | 0.1765 | 0.3529 | |
| GSE23400 | METTL8 | 79828 | 220007_at | 0.2652 | 0.0024 | |
| GSE26886 | METTL8 | 79828 | 1554667_s_at | 0.3674 | 0.3299 | |
| GSE29001 | METTL8 | 79828 | 220007_at | 0.3109 | 0.3619 | |
| GSE38129 | METTL8 | 79828 | 220007_at | 0.1912 | 0.3880 | |
| GSE45670 | METTL8 | 79828 | 1554667_s_at | 0.5368 | 0.0008 | |
| GSE53622 | METTL8 | 79828 | 42745 | 0.3437 | 0.0009 | |
| GSE53624 | METTL8 | 79828 | 42745 | 0.4861 | 0.0000 | |
| GSE63941 | METTL8 | 79828 | 1554667_s_at | -0.1718 | 0.7476 | |
| GSE77861 | METTL8 | 79828 | 1554667_s_at | 0.5885 | 0.0471 | |
| GSE97050 | METTL8 | 79828 | A_33_P3357082 | -0.1613 | 0.4978 | |
| SRP007169 | METTL8 | 79828 | RNAseq | 0.1848 | 0.6049 | |
| SRP008496 | METTL8 | 79828 | RNAseq | 0.1310 | 0.5546 | |
| SRP064894 | METTL8 | 79828 | RNAseq | -0.0905 | 0.5846 | |
| SRP133303 | METTL8 | 79828 | RNAseq | 0.0458 | 0.7303 | |
| SRP159526 | METTL8 | 79828 | RNAseq | -0.4437 | 0.0180 | |
| SRP193095 | METTL8 | 79828 | RNAseq | -0.1026 | 0.5607 | |
| SRP219564 | METTL8 | 79828 | RNAseq | 0.4890 | 0.3757 | |
| TCGA | METTL8 | 79828 | RNAseq | 0.2888 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by METTL8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of METTL8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METTL8 | 79828 | 9 | 0 | 21 | |
| GSE20123 | METTL8 | 79828 | 9 | 0 | 21 | |
| GSE43470 | METTL8 | 79828 | 5 | 1 | 37 | |
| GSE46452 | METTL8 | 79828 | 1 | 4 | 54 | |
| GSE47630 | METTL8 | 79828 | 5 | 3 | 32 | |
| GSE54993 | METTL8 | 79828 | 0 | 5 | 65 | |
| GSE54994 | METTL8 | 79828 | 11 | 3 | 39 | |
| GSE60625 | METTL8 | 79828 | 0 | 3 | 8 | |
| GSE74703 | METTL8 | 79828 | 4 | 1 | 31 | |
| GSE74704 | METTL8 | 79828 | 6 | 0 | 14 | |
| TCGA | METTL8 | 79828 | 27 | 7 | 62 |
Total number of gains: 77; Total number of losses: 27; Total Number of normals: 384.
Somatic mutations of METTL8:
Generating mutation plots.
Highly correlated genes for METTL8:
Showing top 20/710 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METTL8 | CBFA2T2 | 0.841015 | 3 | 0 | 3 |
| METTL8 | CMTM4 | 0.808192 | 3 | 0 | 3 |
| METTL8 | RB1CC1 | 0.782615 | 3 | 0 | 3 |
| METTL8 | ZNF292 | 0.766796 | 3 | 0 | 3 |
| METTL8 | TMEM181 | 0.758305 | 3 | 0 | 3 |
| METTL8 | SMURF2 | 0.746169 | 3 | 0 | 3 |
| METTL8 | COX6C | 0.742138 | 3 | 0 | 3 |
| METTL8 | ANKRD46 | 0.739954 | 4 | 0 | 3 |
| METTL8 | NUCKS1 | 0.739722 | 4 | 0 | 4 |
| METTL8 | TMED8 | 0.738445 | 3 | 0 | 3 |
| METTL8 | SRSF11 | 0.733206 | 3 | 0 | 3 |
| METTL8 | NIT2 | 0.731438 | 5 | 0 | 4 |
| METTL8 | SFR1 | 0.725582 | 3 | 0 | 3 |
| METTL8 | ARID1A | 0.715072 | 3 | 0 | 3 |
| METTL8 | DICER1 | 0.715012 | 4 | 0 | 4 |
| METTL8 | IL6R | 0.70776 | 4 | 0 | 3 |
| METTL8 | GNA13 | 0.700278 | 3 | 0 | 3 |
| METTL8 | COCH | 0.70026 | 4 | 0 | 3 |
| METTL8 | BARD1 | 0.699738 | 4 | 0 | 4 |
| METTL8 | ASB2 | 0.696485 | 3 | 0 | 3 |
For details and further investigation, click here
