| Full name: transmembrane protein 67 | Alias Symbol: MGC26979|JBTS6|NPHP11 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 91147 | HGNC ID: HGNC:28396 | Ensembl Gene: ENSG00000164953 | OMIM ID: 609884 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM67:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM67 | 91147 | 1563646_a_at | 0.2648 | 0.6086 | |
| GSE26886 | TMEM67 | 91147 | 1563646_a_at | -0.2785 | 0.2738 | |
| GSE45670 | TMEM67 | 91147 | 1563646_a_at | 0.2249 | 0.0537 | |
| GSE53622 | TMEM67 | 91147 | 88764 | 0.8744 | 0.0000 | |
| GSE53624 | TMEM67 | 91147 | 88764 | 1.0518 | 0.0000 | |
| GSE63941 | TMEM67 | 91147 | 1563646_a_at | 0.2696 | 0.5994 | |
| GSE77861 | TMEM67 | 91147 | 1563646_a_at | -0.0935 | 0.4027 | |
| GSE97050 | TMEM67 | 91147 | A_23_P429581 | 0.2997 | 0.2395 | |
| SRP007169 | TMEM67 | 91147 | RNAseq | 1.3250 | 0.0021 | |
| SRP008496 | TMEM67 | 91147 | RNAseq | 1.6124 | 0.0000 | |
| SRP064894 | TMEM67 | 91147 | RNAseq | 0.8992 | 0.0019 | |
| SRP133303 | TMEM67 | 91147 | RNAseq | 0.5062 | 0.0006 | |
| SRP159526 | TMEM67 | 91147 | RNAseq | 0.9360 | 0.0029 | |
| SRP193095 | TMEM67 | 91147 | RNAseq | 0.7276 | 0.0000 | |
| SRP219564 | TMEM67 | 91147 | RNAseq | 0.5693 | 0.0190 | |
| TCGA | TMEM67 | 91147 | RNAseq | 0.2599 | 0.0062 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TMEM67 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM67:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM67 | 91147 | 16 | 1 | 13 | |
| GSE20123 | TMEM67 | 91147 | 17 | 1 | 12 | |
| GSE43470 | TMEM67 | 91147 | 21 | 1 | 21 | |
| GSE46452 | TMEM67 | 91147 | 22 | 0 | 37 | |
| GSE47630 | TMEM67 | 91147 | 24 | 0 | 16 | |
| GSE54993 | TMEM67 | 91147 | 0 | 20 | 50 | |
| GSE54994 | TMEM67 | 91147 | 34 | 1 | 18 | |
| GSE60625 | TMEM67 | 91147 | 0 | 4 | 7 | |
| GSE74703 | TMEM67 | 91147 | 18 | 1 | 17 | |
| GSE74704 | TMEM67 | 91147 | 12 | 0 | 8 | |
| TCGA | TMEM67 | 91147 | 56 | 1 | 39 |
Total number of gains: 220; Total number of losses: 30; Total Number of normals: 238.
Somatic mutations of TMEM67:
Generating mutation plots.
Highly correlated genes for TMEM67:
Showing top 20/193 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM67 | NUDCD2 | 0.674974 | 3 | 0 | 3 |
| TMEM67 | IRAK2 | 0.667757 | 3 | 0 | 3 |
| TMEM67 | ALG10B | 0.647928 | 3 | 0 | 3 |
| TMEM67 | ZNF707 | 0.639947 | 3 | 0 | 3 |
| TMEM67 | GNPDA1 | 0.632218 | 5 | 0 | 5 |
| TMEM67 | SAMD15 | 0.629713 | 4 | 0 | 3 |
| TMEM67 | SNAPC1 | 0.62948 | 4 | 0 | 4 |
| TMEM67 | ICE1 | 0.624855 | 4 | 0 | 4 |
| TMEM67 | PAICS | 0.62469 | 3 | 0 | 3 |
| TMEM67 | LINC01431 | 0.624144 | 3 | 0 | 3 |
| TMEM67 | MMS22L | 0.621661 | 3 | 0 | 3 |
| TMEM67 | CENPH | 0.612495 | 4 | 0 | 4 |
| TMEM67 | ZNF622 | 0.612111 | 3 | 0 | 3 |
| TMEM67 | UCK2 | 0.611633 | 3 | 0 | 3 |
| TMEM67 | SUPT16H | 0.609113 | 4 | 0 | 4 |
| TMEM67 | CRCP | 0.608623 | 3 | 0 | 3 |
| TMEM67 | SMARCA5 | 0.604525 | 3 | 0 | 3 |
| TMEM67 | WDR12 | 0.599228 | 5 | 0 | 4 |
| TMEM67 | SNX5 | 0.596047 | 4 | 0 | 3 |
| TMEM67 | RMND1 | 0.59573 | 5 | 0 | 5 |
For details and further investigation, click here
