| Full name: interleukin 1 receptor associated kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 3656 | HGNC ID: HGNC:6113 | Ensembl Gene: ENSG00000134070 | OMIM ID: 603304 |
| Drug and gene relationship at DGIdb | |||
IRAK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway | |
| hsa05152 | Tuberculosis |
Expression of IRAK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRAK2 | 3656 | 231779_at | -0.2397 | 0.8977 | |
| GSE26886 | IRAK2 | 3656 | 231779_at | -1.7135 | 0.0010 | |
| GSE45670 | IRAK2 | 3656 | 231779_at | 0.3962 | 0.1532 | |
| GSE53622 | IRAK2 | 3656 | 79970 | -0.4464 | 0.0249 | |
| GSE53624 | IRAK2 | 3656 | 79970 | -0.9981 | 0.0000 | |
| GSE63941 | IRAK2 | 3656 | 231779_at | -0.2142 | 0.8664 | |
| GSE77861 | IRAK2 | 3656 | 1553740_a_at | -0.1999 | 0.1395 | |
| GSE97050 | IRAK2 | 3656 | A_33_P3352970 | 0.3909 | 0.1955 | |
| SRP007169 | IRAK2 | 3656 | RNAseq | 0.1768 | 0.8503 | |
| SRP064894 | IRAK2 | 3656 | RNAseq | -0.9840 | 0.0002 | |
| SRP133303 | IRAK2 | 3656 | RNAseq | -0.0208 | 0.9245 | |
| SRP159526 | IRAK2 | 3656 | RNAseq | -1.3552 | 0.0121 | |
| SRP193095 | IRAK2 | 3656 | RNAseq | -0.3413 | 0.0899 | |
| SRP219564 | IRAK2 | 3656 | RNAseq | -0.9258 | 0.0960 | |
| TCGA | IRAK2 | 3656 | RNAseq | 0.2623 | 0.0653 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by IRAK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRAK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRAK2 | 3656 | 1 | 18 | 11 | |
| GSE20123 | IRAK2 | 3656 | 1 | 18 | 11 | |
| GSE43470 | IRAK2 | 3656 | 1 | 20 | 22 | |
| GSE46452 | IRAK2 | 3656 | 2 | 17 | 40 | |
| GSE47630 | IRAK2 | 3656 | 2 | 23 | 15 | |
| GSE54993 | IRAK2 | 3656 | 6 | 1 | 63 | |
| GSE54994 | IRAK2 | 3656 | 3 | 31 | 19 | |
| GSE60625 | IRAK2 | 3656 | 5 | 0 | 6 | |
| GSE74703 | IRAK2 | 3656 | 1 | 16 | 19 | |
| GSE74704 | IRAK2 | 3656 | 1 | 11 | 8 | |
| TCGA | IRAK2 | 3656 | 5 | 65 | 26 |
Total number of gains: 28; Total number of losses: 220; Total Number of normals: 240.
Somatic mutations of IRAK2:
Generating mutation plots.
Highly correlated genes for IRAK2:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRAK2 | RNF24 | 0.806627 | 3 | 0 | 3 |
| IRAK2 | TBC1D20 | 0.762798 | 3 | 0 | 3 |
| IRAK2 | CDC123 | 0.759601 | 3 | 0 | 3 |
| IRAK2 | MRPL30 | 0.758957 | 3 | 0 | 3 |
| IRAK2 | ELP4 | 0.758136 | 3 | 0 | 3 |
| IRAK2 | ZFC3H1 | 0.740476 | 3 | 0 | 3 |
| IRAK2 | UBE2G1 | 0.733121 | 3 | 0 | 3 |
| IRAK2 | DNAH1 | 0.732735 | 3 | 0 | 3 |
| IRAK2 | LMAN1 | 0.72936 | 3 | 0 | 3 |
| IRAK2 | HLA-DQB2 | 0.725575 | 3 | 0 | 3 |
| IRAK2 | TJP3 | 0.723273 | 3 | 0 | 3 |
| IRAK2 | VAMP3 | 0.719739 | 3 | 0 | 3 |
| IRAK2 | SLC25A46 | 0.718164 | 3 | 0 | 3 |
| IRAK2 | SLC25A24 | 0.717386 | 3 | 0 | 3 |
| IRAK2 | CAPN7 | 0.717086 | 3 | 0 | 3 |
| IRAK2 | POLR2C | 0.714326 | 3 | 0 | 3 |
| IRAK2 | POLI | 0.714252 | 3 | 0 | 3 |
| IRAK2 | ORMDL2 | 0.714181 | 4 | 0 | 4 |
| IRAK2 | ZNF436 | 0.712512 | 3 | 0 | 3 |
| IRAK2 | EXOC1 | 0.70962 | 3 | 0 | 3 |
For details and further investigation, click here
