WDR12

 

Full name: WD repeat domain 12 Alias Symbol: YTM1|FLJ10881
Type: protein-coding gene Cytoband: 2q33.2
Entrez ID: 55759 HGNC ID: HGNC:14098 Ensembl Gene: ENSG00000138442 OMIM ID: 616620
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of WDR12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WDR12 55759 218512_at 0.9276 0.1976
GSE20347 WDR12 55759 218512_at 0.7310 0.0002
GSE23400 WDR12 55759 218512_at 0.6106 0.0000
GSE26886 WDR12 55759 218512_at 0.3387 0.1767
GSE29001 WDR12 55759 218512_at 0.4646 0.1470
GSE38129 WDR12 55759 218512_at 0.9574 0.0000
GSE45670 WDR12 55759 218512_at 0.5611 0.0035
GSE53622 WDR12 55759 144927 0.6052 0.0000
GSE53624 WDR12 55759 144927 0.8013 0.0000
GSE63941 WDR12 55759 218512_at 0.4284 0.2680
GSE77861 WDR12 55759 218512_at 0.3556 0.1109
GSE97050 WDR12 55759 A_23_P28625 0.5579 0.2590
SRP007169 WDR12 55759 RNAseq -0.1233 0.7513
SRP008496 WDR12 55759 RNAseq -0.1203 0.6030
SRP064894 WDR12 55759 RNAseq 0.1355 0.4251
SRP133303 WDR12 55759 RNAseq 0.2996 0.0162
SRP159526 WDR12 55759 RNAseq -0.0041 0.9831
SRP193095 WDR12 55759 RNAseq 0.0420 0.6503
SRP219564 WDR12 55759 RNAseq 0.1446 0.6169
TCGA WDR12 55759 RNAseq 0.3509 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by WDR12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WDR12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WDR12 55759 7 4 19
GSE20123 WDR12 55759 7 4 19
GSE43470 WDR12 55759 2 3 38
GSE46452 WDR12 55759 1 4 54
GSE47630 WDR12 55759 4 5 31
GSE54993 WDR12 55759 0 3 67
GSE54994 WDR12 55759 10 8 35
GSE60625 WDR12 55759 0 3 8
GSE74703 WDR12 55759 2 2 32
GSE74704 WDR12 55759 3 2 15
TCGA WDR12 55759 20 13 63

Total number of gains: 56; Total number of losses: 51; Total Number of normals: 381.  

 

Somatic mutations of WDR12:

 

Generating mutation plots.

 

Highly correlated genes for WDR12:

 

Showing top 20/1547 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WDR12TYW50.769654404
WDR12TMEM2370.759871707
WDR12MMS22L0.751532303
WDR12CCT50.746148707
WDR12SFR10.74359403
WDR12NOP580.725216908
WDR12GMNN0.72012111011
WDR12NBEAL10.717402505
WDR12PRKDC0.71245710010
WDR12DKC10.709559403
WDR12DCP20.707573303
WDR12UCK20.705649403
WDR12TTK0.70251311010
WDR12PTS0.701564303
WDR12NIF3L10.70079613011
WDR12KIF140.6981981009
WDR12HSPE10.69777213012
WDR12GINS10.6968071009
WDR12HSPD10.69639713011
WDR12TOP2A0.69375711010

For details and further investigation, click here