| Full name: amyloid beta precursor like protein 1 | Alias Symbol: APLP | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 333 | HGNC ID: HGNC:597 | Ensembl Gene: ENSG00000105290 | OMIM ID: 104775 |
| Drug and gene relationship at DGIdb | |||
Expression of APLP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APLP1 | 333 | 209462_at | 0.3495 | 0.3958 | |
| GSE20347 | APLP1 | 333 | 209462_at | 0.0920 | 0.3395 | |
| GSE23400 | APLP1 | 333 | 209462_at | -0.0654 | 0.1276 | |
| GSE26886 | APLP1 | 333 | 209462_at | 0.2844 | 0.0254 | |
| GSE29001 | APLP1 | 333 | 209462_at | 0.1823 | 0.4288 | |
| GSE38129 | APLP1 | 333 | 209462_at | -0.0038 | 0.9825 | |
| GSE45670 | APLP1 | 333 | 209462_at | 0.0617 | 0.6545 | |
| GSE53622 | APLP1 | 333 | 3256 | 0.1987 | 0.1182 | |
| GSE53624 | APLP1 | 333 | 3256 | 0.5109 | 0.0000 | |
| GSE63941 | APLP1 | 333 | 209462_at | -0.3202 | 0.4920 | |
| GSE77861 | APLP1 | 333 | 209462_at | 0.0908 | 0.5420 | |
| GSE97050 | APLP1 | 333 | A_23_P27983 | 0.1360 | 0.7250 | |
| SRP064894 | APLP1 | 333 | RNAseq | 1.7933 | 0.0000 | |
| SRP133303 | APLP1 | 333 | RNAseq | 0.6128 | 0.0822 | |
| SRP159526 | APLP1 | 333 | RNAseq | 1.5498 | 0.0009 | |
| SRP219564 | APLP1 | 333 | RNAseq | 0.5349 | 0.5272 | |
| TCGA | APLP1 | 333 | RNAseq | -1.4003 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by APLP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APLP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APLP1 | 333 | 7 | 4 | 19 | |
| GSE20123 | APLP1 | 333 | 7 | 3 | 20 | |
| GSE43470 | APLP1 | 333 | 3 | 7 | 33 | |
| GSE46452 | APLP1 | 333 | 48 | 1 | 10 | |
| GSE47630 | APLP1 | 333 | 9 | 5 | 26 | |
| GSE54993 | APLP1 | 333 | 17 | 3 | 50 | |
| GSE54994 | APLP1 | 333 | 6 | 9 | 38 | |
| GSE60625 | APLP1 | 333 | 9 | 0 | 2 | |
| GSE74703 | APLP1 | 333 | 3 | 4 | 29 | |
| GSE74704 | APLP1 | 333 | 6 | 1 | 13 | |
| TCGA | APLP1 | 333 | 22 | 10 | 64 |
Total number of gains: 137; Total number of losses: 47; Total Number of normals: 304.
Somatic mutations of APLP1:
Generating mutation plots.
Highly correlated genes for APLP1:
Showing top 20/369 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APLP1 | UCN | 0.735728 | 3 | 0 | 3 |
| APLP1 | ALG12 | 0.691418 | 3 | 0 | 3 |
| APLP1 | TMEM138 | 0.661401 | 3 | 0 | 3 |
| APLP1 | SMARCD1 | 0.660808 | 4 | 0 | 3 |
| APLP1 | COMMD7 | 0.658081 | 3 | 0 | 3 |
| APLP1 | TRIM47 | 0.657703 | 4 | 0 | 3 |
| APLP1 | NXPH4 | 0.65539 | 4 | 0 | 3 |
| APLP1 | C17orf67 | 0.653422 | 3 | 0 | 3 |
| APLP1 | SLC46A1 | 0.652465 | 3 | 0 | 3 |
| APLP1 | AFF2 | 0.64482 | 3 | 0 | 3 |
| APLP1 | CCDC124 | 0.643721 | 3 | 0 | 3 |
| APLP1 | SLC17A6 | 0.642694 | 3 | 0 | 3 |
| APLP1 | SPEN | 0.637702 | 3 | 0 | 3 |
| APLP1 | SYN1 | 0.637643 | 5 | 0 | 4 |
| APLP1 | ANKRD9 | 0.635544 | 3 | 0 | 3 |
| APLP1 | FIBCD1 | 0.631042 | 3 | 0 | 3 |
| APLP1 | PFN1 | 0.626946 | 3 | 0 | 3 |
| APLP1 | TNFSF18 | 0.625197 | 3 | 0 | 3 |
| APLP1 | RFNG | 0.620864 | 3 | 0 | 3 |
| APLP1 | MAST2 | 0.620518 | 6 | 0 | 5 |
For details and further investigation, click here
