| Full name: centromere protein O | Alias Symbol: MGC11266|CENP-O | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 79172 | HGNC ID: HGNC:28152 | Ensembl Gene: ENSG00000138092 | OMIM ID: 611504 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CENPO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CENPO | 79172 | 219472_at | 0.1722 | 0.3622 | |
| GSE20347 | CENPO | 79172 | 219472_at | 0.1762 | 0.0133 | |
| GSE23400 | CENPO | 79172 | 219472_at | 0.0049 | 0.8496 | |
| GSE26886 | CENPO | 79172 | 226118_at | 0.6221 | 0.0201 | |
| GSE29001 | CENPO | 79172 | 219472_at | 0.0613 | 0.6257 | |
| GSE38129 | CENPO | 79172 | 219472_at | 0.1075 | 0.1122 | |
| GSE45670 | CENPO | 79172 | 219472_at | 0.0547 | 0.6614 | |
| GSE53622 | CENPO | 79172 | 55692 | 1.3856 | 0.0000 | |
| GSE53624 | CENPO | 79172 | 55692 | 1.5545 | 0.0000 | |
| GSE63941 | CENPO | 79172 | 226118_at | 0.0905 | 0.8933 | |
| GSE77861 | CENPO | 79172 | 219472_at | -0.0342 | 0.7536 | |
| GSE97050 | CENPO | 79172 | A_24_P276888 | 0.9347 | 0.1359 | |
| SRP007169 | CENPO | 79172 | RNAseq | 1.9804 | 0.0000 | |
| SRP008496 | CENPO | 79172 | RNAseq | 1.9182 | 0.0000 | |
| SRP064894 | CENPO | 79172 | RNAseq | 1.0738 | 0.0000 | |
| SRP133303 | CENPO | 79172 | RNAseq | 1.0106 | 0.0000 | |
| SRP159526 | CENPO | 79172 | RNAseq | 1.5514 | 0.0005 | |
| SRP193095 | CENPO | 79172 | RNAseq | 1.2334 | 0.0000 | |
| SRP219564 | CENPO | 79172 | RNAseq | 1.2620 | 0.0070 | |
| TCGA | CENPO | 79172 | RNAseq | 0.6913 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by CENPO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CENPO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CENPO | 79172 | 11 | 2 | 17 | |
| GSE20123 | CENPO | 79172 | 11 | 2 | 17 | |
| GSE43470 | CENPO | 79172 | 2 | 1 | 40 | |
| GSE46452 | CENPO | 79172 | 3 | 4 | 52 | |
| GSE47630 | CENPO | 79172 | 8 | 0 | 32 | |
| GSE54993 | CENPO | 79172 | 0 | 6 | 64 | |
| GSE54994 | CENPO | 79172 | 10 | 0 | 43 | |
| GSE60625 | CENPO | 79172 | 0 | 3 | 8 | |
| GSE74703 | CENPO | 79172 | 2 | 0 | 34 | |
| GSE74704 | CENPO | 79172 | 9 | 1 | 10 | |
| TCGA | CENPO | 79172 | 36 | 3 | 57 |
Total number of gains: 92; Total number of losses: 22; Total Number of normals: 374.
Somatic mutations of CENPO:
Generating mutation plots.
Highly correlated genes for CENPO:
Showing top 20/1018 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CENPO | SPC24 | 0.806987 | 4 | 0 | 4 |
| CENPO | IQGAP3 | 0.798614 | 4 | 0 | 4 |
| CENPO | UCK2 | 0.772572 | 3 | 0 | 3 |
| CENPO | MMS22L | 0.767717 | 3 | 0 | 3 |
| CENPO | DKC1 | 0.765464 | 3 | 0 | 3 |
| CENPO | CCDC86 | 0.755946 | 3 | 0 | 3 |
| CENPO | NLN | 0.755159 | 3 | 0 | 3 |
| CENPO | GEN1 | 0.745784 | 4 | 0 | 4 |
| CENPO | TTYH3 | 0.740838 | 4 | 0 | 4 |
| CENPO | NUF2 | 0.732344 | 5 | 0 | 4 |
| CENPO | NOP56 | 0.727624 | 3 | 0 | 3 |
| CENPO | SNAP47 | 0.722189 | 3 | 0 | 3 |
| CENPO | XPO5 | 0.719724 | 4 | 0 | 4 |
| CENPO | FAM89A | 0.718195 | 3 | 0 | 3 |
| CENPO | MMP11 | 0.716478 | 3 | 0 | 3 |
| CENPO | WDR54 | 0.714545 | 5 | 0 | 5 |
| CENPO | DNAJB11 | 0.710661 | 4 | 0 | 3 |
| CENPO | KNTC1 | 0.708982 | 5 | 0 | 4 |
| CENPO | NMB | 0.703188 | 4 | 0 | 4 |
| CENPO | UBE2T | 0.702789 | 6 | 0 | 4 |
For details and further investigation, click here
