| Full name: Zic family member 2 | Alias Symbol: HPE5 | ||
| Type: protein-coding gene | Cytoband: 13q32.3 | ||
| Entrez ID: 7546 | HGNC ID: HGNC:12873 | Ensembl Gene: ENSG00000043355 | OMIM ID: 603073 |
| Drug and gene relationship at DGIdb | |||
Expression of ZIC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZIC2 | 7546 | 223642_at | 1.5082 | 0.4334 | |
| GSE26886 | ZIC2 | 7546 | 223642_at | 2.9108 | 0.0000 | |
| GSE45670 | ZIC2 | 7546 | 223642_at | 2.3603 | 0.0015 | |
| GSE53622 | ZIC2 | 7546 | 5227 | 2.4544 | 0.0000 | |
| GSE53624 | ZIC2 | 7546 | 5227 | 2.6812 | 0.0000 | |
| GSE63941 | ZIC2 | 7546 | 223642_at | 3.8348 | 0.0006 | |
| GSE77861 | ZIC2 | 7546 | 223642_at | 1.0487 | 0.0402 | |
| SRP007169 | ZIC2 | 7546 | RNAseq | 6.3324 | 0.0000 | |
| SRP133303 | ZIC2 | 7546 | RNAseq | 2.4550 | 0.0000 | |
| SRP159526 | ZIC2 | 7546 | RNAseq | 5.1663 | 0.0000 | |
| SRP219564 | ZIC2 | 7546 | RNAseq | 4.4691 | 0.0000 | |
| TCGA | ZIC2 | 7546 | RNAseq | 2.5088 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by ZIC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZIC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZIC2 | 7546 | 3 | 9 | 18 | |
| GSE20123 | ZIC2 | 7546 | 3 | 8 | 19 | |
| GSE43470 | ZIC2 | 7546 | 4 | 12 | 27 | |
| GSE46452 | ZIC2 | 7546 | 0 | 32 | 27 | |
| GSE47630 | ZIC2 | 7546 | 3 | 26 | 11 | |
| GSE54993 | ZIC2 | 7546 | 11 | 4 | 55 | |
| GSE54994 | ZIC2 | 7546 | 6 | 10 | 37 | |
| GSE60625 | ZIC2 | 7546 | 0 | 3 | 8 | |
| GSE74703 | ZIC2 | 7546 | 3 | 10 | 23 | |
| GSE74704 | ZIC2 | 7546 | 1 | 8 | 11 | |
| TCGA | ZIC2 | 7546 | 17 | 34 | 45 |
Total number of gains: 51; Total number of losses: 156; Total Number of normals: 281.
Somatic mutations of ZIC2:
Generating mutation plots.
Highly correlated genes for ZIC2:
Showing top 20/766 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZIC2 | ZIC5 | 0.778224 | 4 | 0 | 4 |
| ZIC2 | TENM4 | 0.770007 | 3 | 0 | 3 |
| ZIC2 | BCAM | 0.756492 | 4 | 0 | 4 |
| ZIC2 | FBRSL1 | 0.720946 | 3 | 0 | 3 |
| ZIC2 | FAXC | 0.720717 | 3 | 0 | 3 |
| ZIC2 | CPT1A | 0.712473 | 3 | 0 | 3 |
| ZIC2 | CDK4 | 0.704893 | 5 | 0 | 5 |
| ZIC2 | MTERF3 | 0.697745 | 3 | 0 | 3 |
| ZIC2 | RAD23A | 0.697699 | 4 | 0 | 4 |
| ZIC2 | FZD3 | 0.69457 | 3 | 0 | 3 |
| ZIC2 | MCM7 | 0.693968 | 6 | 0 | 6 |
| ZIC2 | LINC00520 | 0.692545 | 3 | 0 | 3 |
| ZIC2 | SORL1 | 0.687723 | 3 | 0 | 3 |
| ZIC2 | PTPN4 | 0.687063 | 3 | 0 | 3 |
| ZIC2 | PLTP | 0.684582 | 3 | 0 | 3 |
| ZIC2 | DGUOK | 0.683808 | 6 | 0 | 6 |
| ZIC2 | FEN1 | 0.681298 | 4 | 0 | 4 |
| ZIC2 | FOXM1 | 0.68098 | 6 | 0 | 6 |
| ZIC2 | UBE2T | 0.679252 | 7 | 0 | 6 |
| ZIC2 | KRT18 | 0.678798 | 3 | 0 | 3 |
For details and further investigation, click here
