| Full name: STE20 like kinase | Alias Symbol: STK2|se20-9|KIAA0204 | ||
| Type: protein-coding gene | Cytoband: 10q24.33-q25.1 | ||
| Entrez ID: 9748 | HGNC ID: HGNC:11088 | Ensembl Gene: ENSG00000065613 | OMIM ID: 616563 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SLK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis |
Expression of SLK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLK | 9748 | 206875_s_at | -0.6941 | 0.3600 | |
| GSE20347 | SLK | 9748 | 206875_s_at | -1.5662 | 0.0000 | |
| GSE23400 | SLK | 9748 | 206875_s_at | -1.4302 | 0.0000 | |
| GSE26886 | SLK | 9748 | 206874_s_at | -1.0151 | 0.0012 | |
| GSE29001 | SLK | 9748 | 206875_s_at | -1.0018 | 0.0001 | |
| GSE38129 | SLK | 9748 | 206875_s_at | -1.1438 | 0.0000 | |
| GSE45670 | SLK | 9748 | 206875_s_at | -0.6639 | 0.0019 | |
| GSE53622 | SLK | 9748 | 43314 | -1.1629 | 0.0000 | |
| GSE53624 | SLK | 9748 | 43314 | -1.2983 | 0.0000 | |
| GSE63941 | SLK | 9748 | 206875_s_at | -0.3886 | 0.2679 | |
| GSE77861 | SLK | 9748 | 206875_s_at | -1.3257 | 0.0094 | |
| GSE97050 | SLK | 9748 | A_24_P146670 | -0.3663 | 0.1922 | |
| SRP007169 | SLK | 9748 | RNAseq | -1.9188 | 0.0000 | |
| SRP008496 | SLK | 9748 | RNAseq | -1.8140 | 0.0000 | |
| SRP064894 | SLK | 9748 | RNAseq | -2.0114 | 0.0000 | |
| SRP133303 | SLK | 9748 | RNAseq | -1.1135 | 0.0000 | |
| SRP159526 | SLK | 9748 | RNAseq | -1.9500 | 0.0000 | |
| SRP193095 | SLK | 9748 | RNAseq | -1.6234 | 0.0000 | |
| SRP219564 | SLK | 9748 | RNAseq | -1.6885 | 0.0001 | |
| TCGA | SLK | 9748 | RNAseq | -0.0943 | 0.1345 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by SLK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLK | 9748 | 1 | 9 | 20 | |
| GSE20123 | SLK | 9748 | 1 | 8 | 21 | |
| GSE43470 | SLK | 9748 | 2 | 7 | 34 | |
| GSE46452 | SLK | 9748 | 0 | 11 | 48 | |
| GSE47630 | SLK | 9748 | 2 | 14 | 24 | |
| GSE54993 | SLK | 9748 | 8 | 0 | 62 | |
| GSE54994 | SLK | 9748 | 1 | 10 | 42 | |
| GSE60625 | SLK | 9748 | 0 | 0 | 11 | |
| GSE74703 | SLK | 9748 | 1 | 5 | 30 | |
| GSE74704 | SLK | 9748 | 0 | 4 | 16 | |
| TCGA | SLK | 9748 | 6 | 28 | 62 |
Total number of gains: 22; Total number of losses: 96; Total Number of normals: 370.
Somatic mutations of SLK:
Generating mutation plots.
Highly correlated genes for SLK:
Showing top 20/1735 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLK | PDCD6IP | 0.829688 | 11 | 0 | 11 |
| SLK | RNF141 | 0.821737 | 11 | 0 | 11 |
| SLK | USP6NL | 0.81196 | 12 | 0 | 12 |
| SLK | ZNF426 | 0.807141 | 11 | 0 | 11 |
| SLK | SASH1 | 0.806957 | 11 | 0 | 11 |
| SLK | RAB11A | 0.806797 | 11 | 0 | 11 |
| SLK | CAST | 0.800275 | 11 | 0 | 11 |
| SLK | CASC3 | 0.798597 | 3 | 0 | 3 |
| SLK | TTC9 | 0.794027 | 11 | 0 | 11 |
| SLK | CCNG2 | 0.792087 | 12 | 0 | 11 |
| SLK | VPS4B | 0.789995 | 12 | 0 | 12 |
| SLK | CHP1 | 0.789016 | 10 | 0 | 10 |
| SLK | FRMD4B | 0.787326 | 11 | 0 | 11 |
| SLK | ECM1 | 0.785545 | 10 | 0 | 10 |
| SLK | EPS8L2 | 0.784132 | 10 | 0 | 10 |
| SLK | GYS2 | 0.782382 | 10 | 0 | 10 |
| SLK | TMPRSS11E | 0.782311 | 9 | 0 | 9 |
| SLK | TJP1 | 0.780676 | 12 | 0 | 12 |
| SLK | CDS1 | 0.78064 | 10 | 0 | 10 |
| SLK | TICAM1 | 0.780131 | 6 | 0 | 6 |
For details and further investigation, click here
