| Full name: ras responsive element binding protein 1 | Alias Symbol: HNT | ||
| Type: protein-coding gene | Cytoband: 6p24.3 | ||
| Entrez ID: 6239 | HGNC ID: HGNC:10449 | Ensembl Gene: ENSG00000124782 | OMIM ID: 602209 |
| Drug and gene relationship at DGIdb | |||
Expression of RREB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RREB1 | 6239 | 203704_s_at | -0.1987 | 0.7799 | |
| GSE20347 | RREB1 | 6239 | 203704_s_at | -0.8761 | 0.0000 | |
| GSE23400 | RREB1 | 6239 | 203704_s_at | -0.6192 | 0.0000 | |
| GSE26886 | RREB1 | 6239 | 203704_s_at | -0.8621 | 0.0007 | |
| GSE29001 | RREB1 | 6239 | 203704_s_at | -0.8144 | 0.0006 | |
| GSE38129 | RREB1 | 6239 | 203704_s_at | -0.5849 | 0.0073 | |
| GSE45670 | RREB1 | 6239 | 203704_s_at | -0.0236 | 0.9115 | |
| GSE53622 | RREB1 | 6239 | 82545 | -0.4116 | 0.0000 | |
| GSE53624 | RREB1 | 6239 | 82545 | -0.0735 | 0.4474 | |
| GSE63941 | RREB1 | 6239 | 203704_s_at | 0.9477 | 0.0080 | |
| GSE77861 | RREB1 | 6239 | 203704_s_at | -0.6230 | 0.0240 | |
| GSE97050 | RREB1 | 6239 | A_23_P59294 | -0.0121 | 0.9736 | |
| SRP007169 | RREB1 | 6239 | RNAseq | -0.7444 | 0.0163 | |
| SRP008496 | RREB1 | 6239 | RNAseq | -1.0265 | 0.0000 | |
| SRP064894 | RREB1 | 6239 | RNAseq | -0.9593 | 0.0000 | |
| SRP133303 | RREB1 | 6239 | RNAseq | -0.8000 | 0.0000 | |
| SRP159526 | RREB1 | 6239 | RNAseq | -1.1659 | 0.0000 | |
| SRP193095 | RREB1 | 6239 | RNAseq | -0.7960 | 0.0000 | |
| SRP219564 | RREB1 | 6239 | RNAseq | -0.8155 | 0.1865 | |
| TCGA | RREB1 | 6239 | RNAseq | -0.0520 | 0.3809 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by RREB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RREB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RREB1 | 6239 | 4 | 5 | 21 | |
| GSE20123 | RREB1 | 6239 | 4 | 5 | 21 | |
| GSE43470 | RREB1 | 6239 | 10 | 2 | 31 | |
| GSE46452 | RREB1 | 6239 | 1 | 10 | 48 | |
| GSE47630 | RREB1 | 6239 | 7 | 8 | 25 | |
| GSE54993 | RREB1 | 6239 | 1 | 1 | 68 | |
| GSE54994 | RREB1 | 6239 | 10 | 3 | 40 | |
| GSE60625 | RREB1 | 6239 | 0 | 1 | 10 | |
| GSE74703 | RREB1 | 6239 | 8 | 2 | 26 | |
| GSE74704 | RREB1 | 6239 | 2 | 2 | 16 | |
| TCGA | RREB1 | 6239 | 15 | 29 | 52 |
Total number of gains: 62; Total number of losses: 68; Total Number of normals: 358.
Somatic mutations of RREB1:
Generating mutation plots.
Highly correlated genes for RREB1:
Showing top 20/1268 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RREB1 | IMPACT | 0.828303 | 3 | 0 | 3 |
| RREB1 | RNFT1 | 0.826232 | 3 | 0 | 3 |
| RREB1 | RASSF5 | 0.77403 | 6 | 0 | 6 |
| RREB1 | FRMD4B | 0.764818 | 12 | 0 | 11 |
| RREB1 | THUMPD3 | 0.759855 | 4 | 0 | 4 |
| RREB1 | MLKL | 0.7575 | 3 | 0 | 3 |
| RREB1 | CDS1 | 0.756568 | 10 | 0 | 10 |
| RREB1 | TYSND1 | 0.754724 | 3 | 0 | 3 |
| RREB1 | PLD1 | 0.753866 | 10 | 0 | 10 |
| RREB1 | LACTBL1 | 0.753087 | 3 | 0 | 3 |
| RREB1 | RAB5A | 0.746427 | 11 | 0 | 11 |
| RREB1 | RAB11A | 0.745944 | 10 | 0 | 10 |
| RREB1 | TIAM1 | 0.745874 | 11 | 0 | 11 |
| RREB1 | TWF1 | 0.740316 | 10 | 0 | 10 |
| RREB1 | ZNF185 | 0.737848 | 10 | 0 | 10 |
| RREB1 | FAM83G | 0.73617 | 3 | 0 | 3 |
| RREB1 | PGM2 | 0.734373 | 7 | 0 | 7 |
| RREB1 | RBM20 | 0.733554 | 4 | 0 | 4 |
| RREB1 | MALL | 0.733311 | 9 | 0 | 9 |
| RREB1 | VPS4B | 0.73328 | 11 | 0 | 10 |
For details and further investigation, click here
