| Full name: DNA methyltransferase 3 beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 1789 | HGNC ID: HGNC:2979 | Ensembl Gene: ENSG00000088305 | OMIM ID: 602900 |
| Drug and gene relationship at DGIdb | |||
Expression of DNMT3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNMT3B | 1789 | 220668_s_at | 2.5326 | 0.0103 | |
| GSE20347 | DNMT3B | 1789 | 220668_s_at | 1.6590 | 0.0000 | |
| GSE23400 | DNMT3B | 1789 | 220668_s_at | 0.6321 | 0.0000 | |
| GSE26886 | DNMT3B | 1789 | 220668_s_at | 1.3587 | 0.0000 | |
| GSE29001 | DNMT3B | 1789 | 220668_s_at | 1.2631 | 0.0001 | |
| GSE38129 | DNMT3B | 1789 | 220668_s_at | 1.6555 | 0.0000 | |
| GSE45670 | DNMT3B | 1789 | 220668_s_at | 1.7679 | 0.0000 | |
| GSE53622 | DNMT3B | 1789 | 67214 | 1.5576 | 0.0000 | |
| GSE53624 | DNMT3B | 1789 | 29797 | 2.3106 | 0.0000 | |
| GSE63941 | DNMT3B | 1789 | 220668_s_at | 1.4285 | 0.0328 | |
| GSE77861 | DNMT3B | 1789 | 220668_s_at | 0.9330 | 0.0316 | |
| GSE97050 | DNMT3B | 1789 | A_33_P3359508 | -0.0191 | 0.9481 | |
| SRP007169 | DNMT3B | 1789 | RNAseq | 2.5051 | 0.0001 | |
| SRP008496 | DNMT3B | 1789 | RNAseq | 1.9024 | 0.0003 | |
| SRP064894 | DNMT3B | 1789 | RNAseq | 3.1117 | 0.0000 | |
| SRP133303 | DNMT3B | 1789 | RNAseq | 2.2367 | 0.0000 | |
| SRP159526 | DNMT3B | 1789 | RNAseq | 2.1417 | 0.0000 | |
| SRP193095 | DNMT3B | 1789 | RNAseq | 2.5625 | 0.0000 | |
| SRP219564 | DNMT3B | 1789 | RNAseq | 2.4347 | 0.0000 | |
| TCGA | DNMT3B | 1789 | RNAseq | 1.3104 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by DNMT3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNMT3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNMT3B | 1789 | 15 | 0 | 15 | |
| GSE20123 | DNMT3B | 1789 | 15 | 0 | 15 | |
| GSE43470 | DNMT3B | 1789 | 12 | 0 | 31 | |
| GSE46452 | DNMT3B | 1789 | 29 | 0 | 30 | |
| GSE47630 | DNMT3B | 1789 | 24 | 1 | 15 | |
| GSE54993 | DNMT3B | 1789 | 0 | 18 | 52 | |
| GSE54994 | DNMT3B | 1789 | 26 | 1 | 26 | |
| GSE60625 | DNMT3B | 1789 | 0 | 0 | 11 | |
| GSE74703 | DNMT3B | 1789 | 11 | 0 | 25 | |
| GSE74704 | DNMT3B | 1789 | 10 | 0 | 10 | |
| TCGA | DNMT3B | 1789 | 50 | 1 | 45 |
Total number of gains: 192; Total number of losses: 21; Total Number of normals: 275.
Somatic mutations of DNMT3B:
Generating mutation plots.
Highly correlated genes for DNMT3B:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNMT3B | SALL4 | 0.776536 | 7 | 0 | 7 |
| DNMT3B | COL27A1 | 0.774589 | 7 | 0 | 7 |
| DNMT3B | RFT1 | 0.772991 | 3 | 0 | 3 |
| DNMT3B | TNFAIP8L1 | 0.764322 | 6 | 0 | 6 |
| DNMT3B | MRGBP | 0.758133 | 10 | 0 | 10 |
| DNMT3B | MYBL2 | 0.75495 | 11 | 0 | 11 |
| DNMT3B | ZNF114 | 0.754734 | 5 | 0 | 4 |
| DNMT3B | KIF4A | 0.754542 | 12 | 0 | 12 |
| DNMT3B | CMSS1 | 0.753796 | 6 | 0 | 6 |
| DNMT3B | RFX8 | 0.741692 | 3 | 0 | 3 |
| DNMT3B | HOMER3 | 0.737395 | 12 | 0 | 11 |
| DNMT3B | MMP1 | 0.73716 | 10 | 0 | 10 |
| DNMT3B | TTYH3 | 0.733815 | 6 | 0 | 6 |
| DNMT3B | YEATS2 | 0.733249 | 11 | 0 | 11 |
| DNMT3B | MFAP2 | 0.728227 | 10 | 0 | 10 |
| DNMT3B | CHRNA1 | 0.725277 | 3 | 0 | 3 |
| DNMT3B | NCAPH | 0.723369 | 9 | 0 | 9 |
| DNMT3B | TOX2 | 0.721324 | 4 | 0 | 3 |
| DNMT3B | COLGALT1 | 0.721003 | 10 | 0 | 9 |
| DNMT3B | WDR66 | 0.720143 | 7 | 0 | 6 |
For details and further investigation, click here
