| Full name: tribbles pseudokinase 2 | Alias Symbol: TRB2|GS3955 | ||
| Type: protein-coding gene | Cytoband: 2p24.3 | ||
| Entrez ID: 28951 | HGNC ID: HGNC:30809 | Ensembl Gene: ENSG00000071575 | OMIM ID: 609462 |
| Drug and gene relationship at DGIdb | |||
Expression of TRIB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIB2 | 28951 | 202478_at | 0.7817 | 0.4406 | |
| GSE20347 | TRIB2 | 28951 | 202478_at | 1.2702 | 0.0002 | |
| GSE23400 | TRIB2 | 28951 | 202478_at | 1.0533 | 0.0000 | |
| GSE26886 | TRIB2 | 28951 | 202478_at | 0.8554 | 0.0425 | |
| GSE29001 | TRIB2 | 28951 | 202478_at | 0.6358 | 0.1621 | |
| GSE38129 | TRIB2 | 28951 | 202478_at | 1.3536 | 0.0000 | |
| GSE45670 | TRIB2 | 28951 | 202478_at | 0.8126 | 0.0701 | |
| GSE53622 | TRIB2 | 28951 | 59663 | 0.6232 | 0.0000 | |
| GSE53624 | TRIB2 | 28951 | 59663 | 0.8401 | 0.0000 | |
| GSE63941 | TRIB2 | 28951 | 202478_at | -2.4048 | 0.0308 | |
| GSE77861 | TRIB2 | 28951 | 202478_at | 1.9498 | 0.0063 | |
| GSE97050 | TRIB2 | 28951 | A_24_P396753 | 0.6199 | 0.1555 | |
| SRP007169 | TRIB2 | 28951 | RNAseq | 2.3719 | 0.0003 | |
| SRP008496 | TRIB2 | 28951 | RNAseq | 2.1437 | 0.0000 | |
| SRP064894 | TRIB2 | 28951 | RNAseq | 1.1226 | 0.0000 | |
| SRP133303 | TRIB2 | 28951 | RNAseq | 0.6297 | 0.0072 | |
| SRP159526 | TRIB2 | 28951 | RNAseq | 2.0245 | 0.0004 | |
| SRP193095 | TRIB2 | 28951 | RNAseq | 0.7584 | 0.0011 | |
| SRP219564 | TRIB2 | 28951 | RNAseq | 0.4089 | 0.1571 | |
| TCGA | TRIB2 | 28951 | RNAseq | -0.1091 | 0.2963 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by TRIB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIB2 | 28951 | 9 | 2 | 19 | |
| GSE20123 | TRIB2 | 28951 | 9 | 2 | 19 | |
| GSE43470 | TRIB2 | 28951 | 2 | 0 | 41 | |
| GSE46452 | TRIB2 | 28951 | 3 | 4 | 52 | |
| GSE47630 | TRIB2 | 28951 | 7 | 0 | 33 | |
| GSE54993 | TRIB2 | 28951 | 0 | 7 | 63 | |
| GSE54994 | TRIB2 | 28951 | 11 | 0 | 42 | |
| GSE60625 | TRIB2 | 28951 | 0 | 3 | 8 | |
| GSE74703 | TRIB2 | 28951 | 2 | 0 | 34 | |
| GSE74704 | TRIB2 | 28951 | 8 | 2 | 10 | |
| TCGA | TRIB2 | 28951 | 34 | 5 | 57 |
Total number of gains: 85; Total number of losses: 25; Total Number of normals: 378.
Somatic mutations of TRIB2:
Generating mutation plots.
Highly correlated genes for TRIB2:
Showing top 20/1092 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIB2 | ZNF202 | 0.76764 | 3 | 0 | 3 |
| TRIB2 | NAGLU | 0.759155 | 4 | 0 | 4 |
| TRIB2 | CCDC117 | 0.751742 | 3 | 0 | 3 |
| TRIB2 | ALPK2 | 0.722786 | 3 | 0 | 3 |
| TRIB2 | MRPS5 | 0.721584 | 3 | 0 | 3 |
| TRIB2 | FLNB | 0.717878 | 3 | 0 | 3 |
| TRIB2 | GCLC | 0.716836 | 5 | 0 | 3 |
| TRIB2 | BTBD6 | 0.705379 | 3 | 0 | 3 |
| TRIB2 | ZNF317 | 0.705152 | 4 | 0 | 3 |
| TRIB2 | ELAVL1 | 0.702897 | 6 | 0 | 6 |
| TRIB2 | HEY1 | 0.700173 | 11 | 0 | 11 |
| TRIB2 | RAB39B | 0.69574 | 3 | 0 | 3 |
| TRIB2 | SHISA2 | 0.693661 | 6 | 0 | 5 |
| TRIB2 | UXS1 | 0.690349 | 6 | 0 | 4 |
| TRIB2 | AMMECR1L | 0.685385 | 5 | 0 | 3 |
| TRIB2 | GORAB | 0.684044 | 6 | 0 | 5 |
| TRIB2 | RICTOR | 0.683949 | 3 | 0 | 3 |
| TRIB2 | XPO1 | 0.681127 | 9 | 0 | 8 |
| TRIB2 | SFXN4 | 0.678633 | 3 | 0 | 3 |
| TRIB2 | ETV5 | 0.678327 | 13 | 0 | 11 |
For details and further investigation, click here
