| Full name: trio Rho guanine nucleotide exchange factor | Alias Symbol: ARHGEF23 | ||
| Type: protein-coding gene | Cytoband: 5p15.2 | ||
| Entrez ID: 7204 | HGNC ID: HGNC:12303 | Ensembl Gene: ENSG00000038382 | OMIM ID: 601893 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRIO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIO | 7204 | 209011_at | 0.6790 | 0.1012 | |
| GSE20347 | TRIO | 7204 | 209013_x_at | 0.5689 | 0.0004 | |
| GSE23400 | TRIO | 7204 | 209011_at | 0.3848 | 0.0000 | |
| GSE26886 | TRIO | 7204 | 209012_at | 1.0384 | 0.0000 | |
| GSE29001 | TRIO | 7204 | 209012_at | 0.9768 | 0.0035 | |
| GSE38129 | TRIO | 7204 | 209013_x_at | 0.4968 | 0.0068 | |
| GSE45670 | TRIO | 7204 | 209012_at | 0.3174 | 0.3320 | |
| GSE53622 | TRIO | 7204 | 122722 | 1.1048 | 0.0000 | |
| GSE53624 | TRIO | 7204 | 122722 | 1.4501 | 0.0000 | |
| GSE63941 | TRIO | 7204 | 209011_at | 0.5327 | 0.1992 | |
| GSE77861 | TRIO | 7204 | 209011_at | 0.9489 | 0.0085 | |
| GSE97050 | TRIO | 7204 | A_23_P425880 | 1.1460 | 0.0631 | |
| SRP007169 | TRIO | 7204 | RNAseq | 2.8504 | 0.0000 | |
| SRP008496 | TRIO | 7204 | RNAseq | 2.8003 | 0.0000 | |
| SRP064894 | TRIO | 7204 | RNAseq | 0.8928 | 0.0038 | |
| SRP133303 | TRIO | 7204 | RNAseq | 1.0595 | 0.0000 | |
| SRP159526 | TRIO | 7204 | RNAseq | 0.8932 | 0.0069 | |
| SRP193095 | TRIO | 7204 | RNAseq | 1.6103 | 0.0000 | |
| SRP219564 | TRIO | 7204 | RNAseq | 0.8793 | 0.0166 | |
| TCGA | TRIO | 7204 | RNAseq | 0.1089 | 0.0989 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by TRIO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIO | 7204 | 12 | 0 | 18 | |
| GSE20123 | TRIO | 7204 | 12 | 0 | 18 | |
| GSE43470 | TRIO | 7204 | 18 | 0 | 25 | |
| GSE46452 | TRIO | 7204 | 6 | 22 | 31 | |
| GSE47630 | TRIO | 7204 | 6 | 11 | 23 | |
| GSE54993 | TRIO | 7204 | 5 | 5 | 60 | |
| GSE54994 | TRIO | 7204 | 29 | 2 | 22 | |
| GSE60625 | TRIO | 7204 | 0 | 0 | 11 | |
| GSE74703 | TRIO | 7204 | 14 | 0 | 22 | |
| GSE74704 | TRIO | 7204 | 11 | 0 | 9 | |
| TCGA | TRIO | 7204 | 59 | 3 | 34 |
Total number of gains: 172; Total number of losses: 43; Total Number of normals: 273.
Somatic mutations of TRIO:
Generating mutation plots.
Highly correlated genes for TRIO:
Showing top 20/1783 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIO | CMTM4 | 0.792589 | 3 | 0 | 3 |
| TRIO | FMNL2 | 0.790662 | 7 | 0 | 7 |
| TRIO | PDE7A | 0.786787 | 7 | 0 | 7 |
| TRIO | FNDC3B | 0.769622 | 11 | 0 | 11 |
| TRIO | PDCD2L | 0.767119 | 3 | 0 | 3 |
| TRIO | TP53I13 | 0.757487 | 6 | 0 | 6 |
| TRIO | FADS1 | 0.757173 | 3 | 0 | 3 |
| TRIO | PELI2 | 0.757077 | 3 | 0 | 3 |
| TRIO | LPCAT1 | 0.752754 | 12 | 0 | 11 |
| TRIO | PKIG | 0.750035 | 3 | 0 | 3 |
| TRIO | SPON2 | 0.749996 | 3 | 0 | 3 |
| TRIO | NXN | 0.749911 | 3 | 0 | 3 |
| TRIO | RAB34 | 0.740428 | 3 | 0 | 3 |
| TRIO | CENPV | 0.739306 | 3 | 0 | 3 |
| TRIO | RILPL1 | 0.738462 | 4 | 0 | 4 |
| TRIO | LOXL2 | 0.737902 | 11 | 0 | 11 |
| TRIO | B3GNT9 | 0.732891 | 7 | 0 | 7 |
| TRIO | RAVER1 | 0.729374 | 4 | 0 | 3 |
| TRIO | SOCS7 | 0.72916 | 3 | 0 | 3 |
| TRIO | PYCR2 | 0.725707 | 3 | 0 | 3 |
For details and further investigation, click here
