| Full name: lysyl oxidase like 2 | Alias Symbol: WS9-14|LOR | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 4017 | HGNC ID: HGNC:6666 | Ensembl Gene: ENSG00000134013 | OMIM ID: 606663 |
| Drug and gene relationship at DGIdb | |||
Expression of LOXL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LOXL2 | 4017 | 202998_s_at | 1.9891 | 0.0486 | |
| GSE20347 | LOXL2 | 4017 | 202998_s_at | 1.9137 | 0.0000 | |
| GSE23400 | LOXL2 | 4017 | 202998_s_at | 1.4033 | 0.0000 | |
| GSE26886 | LOXL2 | 4017 | 202998_s_at | 2.9557 | 0.0000 | |
| GSE29001 | LOXL2 | 4017 | 202998_s_at | 0.9910 | 0.0109 | |
| GSE38129 | LOXL2 | 4017 | 202998_s_at | 1.6773 | 0.0000 | |
| GSE45670 | LOXL2 | 4017 | 202998_s_at | 1.6598 | 0.0040 | |
| GSE53622 | LOXL2 | 4017 | 79176 | 2.4931 | 0.0000 | |
| GSE53624 | LOXL2 | 4017 | 79176 | 2.8420 | 0.0000 | |
| GSE63941 | LOXL2 | 4017 | 202998_s_at | -2.8324 | 0.0982 | |
| GSE77861 | LOXL2 | 4017 | 202998_s_at | 2.2644 | 0.0382 | |
| GSE97050 | LOXL2 | 4017 | A_23_P111995 | 1.0370 | 0.1200 | |
| SRP007169 | LOXL2 | 4017 | RNAseq | 4.7008 | 0.0000 | |
| SRP008496 | LOXL2 | 4017 | RNAseq | 5.6492 | 0.0000 | |
| SRP064894 | LOXL2 | 4017 | RNAseq | 3.2111 | 0.0000 | |
| SRP133303 | LOXL2 | 4017 | RNAseq | 3.3525 | 0.0000 | |
| SRP159526 | LOXL2 | 4017 | RNAseq | 1.7379 | 0.0000 | |
| SRP193095 | LOXL2 | 4017 | RNAseq | 3.0755 | 0.0000 | |
| TCGA | LOXL2 | 4017 | RNAseq | 0.5033 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by LOXL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LOXL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LOXL2 | 4017 | 4 | 12 | 14 | |
| GSE20123 | LOXL2 | 4017 | 4 | 12 | 14 | |
| GSE43470 | LOXL2 | 4017 | 4 | 9 | 30 | |
| GSE46452 | LOXL2 | 4017 | 13 | 13 | 33 | |
| GSE47630 | LOXL2 | 4017 | 10 | 8 | 22 | |
| GSE54993 | LOXL2 | 4017 | 2 | 14 | 54 | |
| GSE54994 | LOXL2 | 4017 | 8 | 18 | 27 | |
| GSE60625 | LOXL2 | 4017 | 3 | 0 | 8 | |
| GSE74703 | LOXL2 | 4017 | 4 | 7 | 25 | |
| GSE74704 | LOXL2 | 4017 | 3 | 8 | 9 | |
| TCGA | LOXL2 | 4017 | 15 | 42 | 39 |
Total number of gains: 70; Total number of losses: 143; Total Number of normals: 275.
Somatic mutations of LOXL2:
Generating mutation plots.
Highly correlated genes for LOXL2:
Showing top 20/1738 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LOXL2 | MFAP2 | 0.85088 | 11 | 0 | 11 |
| LOXL2 | INHBA | 0.849285 | 12 | 0 | 12 |
| LOXL2 | COL5A1 | 0.845523 | 12 | 0 | 12 |
| LOXL2 | TGFBI | 0.829602 | 12 | 0 | 12 |
| LOXL2 | COL5A2 | 0.822226 | 12 | 0 | 12 |
| LOXL2 | CTHRC1 | 0.821164 | 8 | 0 | 8 |
| LOXL2 | BGN | 0.809212 | 12 | 0 | 12 |
| LOXL2 | FAP | 0.808272 | 10 | 0 | 10 |
| LOXL2 | WDR54 | 0.800399 | 7 | 0 | 7 |
| LOXL2 | PMEPA1 | 0.799272 | 11 | 0 | 10 |
| LOXL2 | TTYH3 | 0.798632 | 7 | 0 | 7 |
| LOXL2 | CDH11 | 0.795678 | 12 | 0 | 12 |
| LOXL2 | FADS1 | 0.789383 | 3 | 0 | 3 |
| LOXL2 | VCAN | 0.786905 | 12 | 0 | 11 |
| LOXL2 | SPON2 | 0.783673 | 3 | 0 | 3 |
| LOXL2 | COL1A1 | 0.783153 | 11 | 0 | 11 |
| LOXL2 | PDIA5 | 0.781955 | 3 | 0 | 3 |
| LOXL2 | PYCR2 | 0.781821 | 3 | 0 | 3 |
| LOXL2 | PXDN | 0.780705 | 12 | 0 | 12 |
| LOXL2 | SERPINE1 | 0.779964 | 12 | 0 | 12 |
For details and further investigation, click here
