| Full name: U2 small nuclear RNA auxiliary factor 1 | Alias Symbol: U2AF35|RNU2AF1|RN | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 7307 | HGNC ID: HGNC:12453 | Ensembl Gene: ENSG00000160201 | OMIM ID: 191317 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
U2AF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05131 | Shigellosis |
Expression of U2AF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | U2AF1 | 7307 | 202858_at | 0.3195 | 0.2915 | |
| GSE20347 | U2AF1 | 7307 | 202858_at | 0.2752 | 0.0005 | |
| GSE23400 | U2AF1 | 7307 | 202858_at | 0.1709 | 0.0159 | |
| GSE26886 | U2AF1 | 7307 | 202858_at | 0.1749 | 0.5344 | |
| GSE29001 | U2AF1 | 7307 | 202858_at | 0.2241 | 0.6106 | |
| GSE38129 | U2AF1 | 7307 | 202858_at | 0.2812 | 0.0216 | |
| GSE45670 | U2AF1 | 7307 | 202858_at | 0.2172 | 0.0396 | |
| GSE63941 | U2AF1 | 7307 | 202858_at | 0.5293 | 0.0611 | |
| GSE77861 | U2AF1 | 7307 | 202858_at | 0.4395 | 0.1032 | |
| GSE97050 | U2AF1 | 7307 | A_23_P6303 | -0.3239 | 0.1986 | |
| SRP159526 | U2AF1 | 7307 | RNAseq | -0.0689 | 0.9639 | |
| SRP219564 | U2AF1 | 7307 | RNAseq | 0.2186 | 0.7176 | |
| TCGA | U2AF1 | 7307 | RNAseq | 0.1071 | 0.0294 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by U2AF1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of U2AF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | U2AF1 | 7307 | 2 | 8 | 20 | |
| GSE20123 | U2AF1 | 7307 | 2 | 8 | 20 | |
| GSE43470 | U2AF1 | 7307 | 0 | 13 | 30 | |
| GSE46452 | U2AF1 | 7307 | 1 | 21 | 37 | |
| GSE47630 | U2AF1 | 7307 | 6 | 17 | 17 | |
| GSE54993 | U2AF1 | 7307 | 8 | 1 | 61 | |
| GSE54994 | U2AF1 | 7307 | 4 | 8 | 41 | |
| GSE60625 | U2AF1 | 7307 | 0 | 0 | 11 | |
| GSE74703 | U2AF1 | 7307 | 0 | 10 | 26 | |
| GSE74704 | U2AF1 | 7307 | 1 | 4 | 15 | |
| TCGA | U2AF1 | 7307 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of U2AF1:
Generating mutation plots.
Highly correlated genes for U2AF1:
Showing top 20/1072 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| U2AF1 | THAP5 | 0.796634 | 3 | 0 | 3 |
| U2AF1 | ERGIC2 | 0.788646 | 3 | 0 | 3 |
| U2AF1 | MOB3C | 0.769979 | 4 | 0 | 4 |
| U2AF1 | PIGU | 0.765895 | 3 | 0 | 3 |
| U2AF1 | TRPM4 | 0.752911 | 3 | 0 | 3 |
| U2AF1 | WDR54 | 0.74953 | 3 | 0 | 3 |
| U2AF1 | SPSB2 | 0.734369 | 3 | 0 | 3 |
| U2AF1 | COMMD7 | 0.732559 | 3 | 0 | 3 |
| U2AF1 | RIMKLA | 0.729307 | 3 | 0 | 3 |
| U2AF1 | ZNF672 | 0.726994 | 3 | 0 | 3 |
| U2AF1 | ARF3 | 0.725433 | 3 | 0 | 3 |
| U2AF1 | KLHDC3 | 0.716269 | 4 | 0 | 3 |
| U2AF1 | C12orf73 | 0.713131 | 3 | 0 | 3 |
| U2AF1 | IFT52 | 0.711829 | 3 | 0 | 3 |
| U2AF1 | WDR4 | 0.711217 | 3 | 0 | 3 |
| U2AF1 | RSBN1L | 0.709862 | 3 | 0 | 3 |
| U2AF1 | SNUPN | 0.709856 | 4 | 0 | 4 |
| U2AF1 | SP4 | 0.708402 | 3 | 0 | 3 |
| U2AF1 | MSL2 | 0.707447 | 4 | 0 | 4 |
| U2AF1 | ELMO1 | 0.70302 | 3 | 0 | 3 |
For details and further investigation, click here
