| Full name: serine/threonine kinase 4 | Alias Symbol: MST1|KRS2|YSK3 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 6789 | HGNC ID: HGNC:11408 | Ensembl Gene: ENSG00000101109 | OMIM ID: 604965 |
| Drug and gene relationship at DGIdb | |||
STK4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway | |
| hsa04068 | FoxO signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05223 | Non-small cell lung cancer |
Expression of STK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STK4 | 6789 | 225364_at | 0.5562 | 0.1310 | |
| GSE20347 | STK4 | 6789 | 211085_s_at | 0.2499 | 0.0808 | |
| GSE23400 | STK4 | 6789 | 205411_at | -0.1443 | 0.0002 | |
| GSE26886 | STK4 | 6789 | 225364_at | 0.5022 | 0.0125 | |
| GSE29001 | STK4 | 6789 | 205411_at | -0.1278 | 0.3866 | |
| GSE38129 | STK4 | 6789 | 211085_s_at | 0.2995 | 0.0495 | |
| GSE45670 | STK4 | 6789 | 225364_at | 0.2216 | 0.0851 | |
| GSE53622 | STK4 | 6789 | 7572 | 0.3252 | 0.0000 | |
| GSE53624 | STK4 | 6789 | 7572 | 0.1787 | 0.0450 | |
| GSE63941 | STK4 | 6789 | 225364_at | 0.3862 | 0.4538 | |
| GSE77861 | STK4 | 6789 | 225364_at | 0.2342 | 0.3734 | |
| GSE97050 | STK4 | 6789 | A_33_P3222648 | 0.2856 | 0.2832 | |
| SRP007169 | STK4 | 6789 | RNAseq | 0.6350 | 0.0907 | |
| SRP008496 | STK4 | 6789 | RNAseq | 0.7590 | 0.0004 | |
| SRP064894 | STK4 | 6789 | RNAseq | 0.2521 | 0.2606 | |
| SRP133303 | STK4 | 6789 | RNAseq | 0.2591 | 0.0085 | |
| SRP159526 | STK4 | 6789 | RNAseq | -0.2328 | 0.4901 | |
| SRP193095 | STK4 | 6789 | RNAseq | 0.1672 | 0.1359 | |
| SRP219564 | STK4 | 6789 | RNAseq | 0.2152 | 0.5658 | |
| TCGA | STK4 | 6789 | RNAseq | 0.0614 | 0.2025 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STK4 | 6789 | 13 | 1 | 16 | |
| GSE20123 | STK4 | 6789 | 13 | 1 | 16 | |
| GSE43470 | STK4 | 6789 | 12 | 1 | 30 | |
| GSE46452 | STK4 | 6789 | 29 | 0 | 30 | |
| GSE47630 | STK4 | 6789 | 24 | 1 | 15 | |
| GSE54993 | STK4 | 6789 | 0 | 17 | 53 | |
| GSE54994 | STK4 | 6789 | 25 | 0 | 28 | |
| GSE60625 | STK4 | 6789 | 0 | 0 | 11 | |
| GSE74703 | STK4 | 6789 | 10 | 1 | 25 | |
| GSE74704 | STK4 | 6789 | 9 | 0 | 11 | |
| TCGA | STK4 | 6789 | 45 | 3 | 48 |
Total number of gains: 180; Total number of losses: 25; Total Number of normals: 283.
Somatic mutations of STK4:
Generating mutation plots.
Highly correlated genes for STK4:
Showing top 20/514 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STK4 | SMCR8 | 0.784399 | 3 | 0 | 3 |
| STK4 | PREX1 | 0.78216 | 3 | 0 | 3 |
| STK4 | MRPS14 | 0.760385 | 3 | 0 | 3 |
| STK4 | SMARCAD1 | 0.747161 | 3 | 0 | 3 |
| STK4 | SSBP4 | 0.74453 | 3 | 0 | 3 |
| STK4 | SEC22C | 0.742145 | 3 | 0 | 3 |
| STK4 | TSEN34 | 0.731373 | 3 | 0 | 3 |
| STK4 | PACS1 | 0.730919 | 4 | 0 | 4 |
| STK4 | NUB1 | 0.730125 | 3 | 0 | 3 |
| STK4 | ROMO1 | 0.72309 | 3 | 0 | 3 |
| STK4 | WTAP | 0.722192 | 3 | 0 | 3 |
| STK4 | LRRC14 | 0.714809 | 3 | 0 | 3 |
| STK4 | SLC9A1 | 0.714195 | 3 | 0 | 3 |
| STK4 | LMO1 | 0.707155 | 3 | 0 | 3 |
| STK4 | RICTOR | 0.705294 | 4 | 0 | 3 |
| STK4 | MCAM | 0.704708 | 3 | 0 | 3 |
| STK4 | TRIM47 | 0.703403 | 5 | 0 | 4 |
| STK4 | ZBTB25 | 0.701892 | 3 | 0 | 3 |
| STK4 | RPL7L1 | 0.69755 | 3 | 0 | 3 |
| STK4 | TGS1 | 0.697289 | 4 | 0 | 4 |
For details and further investigation, click here
