| Full name: CD3e molecule associated protein | Alias Symbol: ASE-1|CAST|PAF49 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 10849 | HGNC ID: HGNC:24219 | Ensembl Gene: ENSG00000117877 | OMIM ID: 107325 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CD3EAP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD3EAP | 10849 | 205264_at | 1.1954 | 0.0502 | |
| GSE20347 | CD3EAP | 10849 | 205264_at | 0.5952 | 0.0009 | |
| GSE23400 | CD3EAP | 10849 | 205264_at | 0.4671 | 0.0000 | |
| GSE26886 | CD3EAP | 10849 | 205264_at | 0.4660 | 0.0259 | |
| GSE29001 | CD3EAP | 10849 | 205264_at | 0.2991 | 0.2934 | |
| GSE38129 | CD3EAP | 10849 | 205264_at | 0.6635 | 0.0000 | |
| GSE45670 | CD3EAP | 10849 | 205264_at | 0.6068 | 0.0005 | |
| GSE53622 | CD3EAP | 10849 | 26409 | 0.4381 | 0.0000 | |
| GSE53624 | CD3EAP | 10849 | 26409 | 0.6111 | 0.0000 | |
| GSE63941 | CD3EAP | 10849 | 205264_at | 1.0799 | 0.0022 | |
| GSE77861 | CD3EAP | 10849 | 205264_at | 0.5004 | 0.0574 | |
| GSE97050 | CD3EAP | 10849 | A_23_P208310 | 0.1525 | 0.4287 | |
| SRP007169 | CD3EAP | 10849 | RNAseq | 1.2624 | 0.0136 | |
| SRP008496 | CD3EAP | 10849 | RNAseq | 1.2392 | 0.0037 | |
| SRP064894 | CD3EAP | 10849 | RNAseq | 0.7773 | 0.0069 | |
| SRP133303 | CD3EAP | 10849 | RNAseq | 0.7182 | 0.0000 | |
| SRP159526 | CD3EAP | 10849 | RNAseq | 1.0462 | 0.0170 | |
| SRP193095 | CD3EAP | 10849 | RNAseq | 0.3542 | 0.0037 | |
| SRP219564 | CD3EAP | 10849 | RNAseq | 0.3852 | 0.4028 | |
| TCGA | CD3EAP | 10849 | RNAseq | 0.2497 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CD3EAP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD3EAP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD3EAP | 10849 | 4 | 5 | 21 | |
| GSE20123 | CD3EAP | 10849 | 4 | 4 | 22 | |
| GSE43470 | CD3EAP | 10849 | 3 | 11 | 29 | |
| GSE46452 | CD3EAP | 10849 | 45 | 1 | 13 | |
| GSE47630 | CD3EAP | 10849 | 8 | 6 | 26 | |
| GSE54993 | CD3EAP | 10849 | 17 | 4 | 49 | |
| GSE54994 | CD3EAP | 10849 | 6 | 12 | 35 | |
| GSE60625 | CD3EAP | 10849 | 9 | 0 | 2 | |
| GSE74703 | CD3EAP | 10849 | 3 | 7 | 26 | |
| GSE74704 | CD3EAP | 10849 | 4 | 2 | 14 | |
| TCGA | CD3EAP | 10849 | 15 | 16 | 65 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of CD3EAP:
Generating mutation plots.
Highly correlated genes for CD3EAP:
Showing top 20/1449 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD3EAP | MRPS5 | 0.80796 | 3 | 0 | 3 |
| CD3EAP | ZNF518B | 0.789575 | 3 | 0 | 3 |
| CD3EAP | CCDC14 | 0.777254 | 3 | 0 | 3 |
| CD3EAP | SOCS4 | 0.76828 | 3 | 0 | 3 |
| CD3EAP | ROMO1 | 0.76564 | 3 | 0 | 3 |
| CD3EAP | WDR89 | 0.761202 | 3 | 0 | 3 |
| CD3EAP | DDX55 | 0.754708 | 6 | 0 | 6 |
| CD3EAP | BCAS4 | 0.747624 | 3 | 0 | 3 |
| CD3EAP | PHC2 | 0.746396 | 4 | 0 | 4 |
| CD3EAP | FAU | 0.739903 | 3 | 0 | 3 |
| CD3EAP | ANKRD17 | 0.73432 | 3 | 0 | 3 |
| CD3EAP | VCP | 0.728845 | 3 | 0 | 3 |
| CD3EAP | RAD18 | 0.727779 | 3 | 0 | 3 |
| CD3EAP | ZNF623 | 0.725478 | 4 | 0 | 3 |
| CD3EAP | TFDP2 | 0.720084 | 3 | 0 | 3 |
| CD3EAP | LRP8 | 0.716633 | 7 | 0 | 7 |
| CD3EAP | R3HDM2 | 0.714652 | 3 | 0 | 3 |
| CD3EAP | LEMD2 | 0.71262 | 4 | 0 | 3 |
| CD3EAP | TSHR | 0.711991 | 3 | 0 | 3 |
| CD3EAP | ZNF451 | 0.710861 | 4 | 0 | 4 |
For details and further investigation, click here
