XPO6

 

Full name: exportin 6 Alias Symbol: KIAA0370|FLJ22519
Type: protein-coding gene Cytoband: 16p11.2
Entrez ID: 23214 HGNC ID: HGNC:19733 Ensembl Gene: ENSG00000169180 OMIM ID: 608411
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of XPO6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 XPO6 23214 211982_x_at 0.5196 0.1387
GSE20347 XPO6 23214 211982_x_at 0.3833 0.0015
GSE23400 XPO6 23214 211982_x_at 0.4172 0.0000
GSE26886 XPO6 23214 214784_x_at 0.0877 0.5479
GSE29001 XPO6 23214 214784_x_at 0.2285 0.0843
GSE38129 XPO6 23214 211982_x_at 0.3847 0.0000
GSE45670 XPO6 23214 214784_x_at 0.4789 0.0000
GSE53622 XPO6 23214 28927 0.6452 0.0000
GSE53624 XPO6 23214 28927 0.7119 0.0000
GSE63941 XPO6 23214 211982_x_at -0.5775 0.1207
GSE77861 XPO6 23214 214784_x_at 0.1400 0.5965
GSE97050 XPO6 23214 A_23_P325438 0.4113 0.1692
SRP007169 XPO6 23214 RNAseq 1.2477 0.0003
SRP008496 XPO6 23214 RNAseq 1.1603 0.0000
SRP064894 XPO6 23214 RNAseq 0.4223 0.0002
SRP133303 XPO6 23214 RNAseq 0.5556 0.0005
SRP159526 XPO6 23214 RNAseq 0.1963 0.1540
SRP193095 XPO6 23214 RNAseq 0.5575 0.0000
SRP219564 XPO6 23214 RNAseq 0.3800 0.2053
TCGA XPO6 23214 RNAseq 0.1197 0.0062

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by XPO6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of XPO6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 XPO6 23214 4 5 21
GSE20123 XPO6 23214 4 4 22
GSE43470 XPO6 23214 4 3 36
GSE46452 XPO6 23214 38 1 20
GSE47630 XPO6 23214 11 7 22
GSE54993 XPO6 23214 3 5 62
GSE54994 XPO6 23214 4 9 40
GSE60625 XPO6 23214 4 0 7
GSE74703 XPO6 23214 4 2 30
GSE74704 XPO6 23214 3 2 15
TCGA XPO6 23214 20 12 64

Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.  

 

Somatic mutations of XPO6:

 

Generating mutation plots.

 

Highly correlated genes for XPO6:

 

Showing top 20/1238 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
XPO6ZBTB90.793648505
XPO6POLDIP20.766971303
XPO6ZBED40.759388303
XPO6EBNA1BP20.752317303
XPO6DIP2B0.745294303
XPO6TP53I130.742792303
XPO6EME10.742364303
XPO6YIF1A0.735875605
XPO6SCNM10.735422303
XPO6USP380.734232303
XPO6E2F70.73306404
XPO6SPNS10.730248504
XPO6PSMD20.729995808
XPO6LETM20.729629303
XPO6TPM30.728735505
XPO6TTC40.72506808
XPO6ALG10.72484403
XPO6PYCR20.724576303
XPO6UTP230.722956303
XPO6SLC35B20.721372303

For details and further investigation, click here