| Full name: transcription termination factor 2 | Alias Symbol: HuF2|ZGRF6 | ||
| Type: protein-coding gene | Cytoband: 1p13.1 | ||
| Entrez ID: 8458 | HGNC ID: HGNC:12398 | Ensembl Gene: ENSG00000116830 | OMIM ID: 604718 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TTF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04918 | Thyroid hormone synthesis |
Expression of TTF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTF2 | 8458 | 204407_at | 0.3035 | 0.5485 | |
| GSE20347 | TTF2 | 8458 | 204407_at | 0.6204 | 0.0004 | |
| GSE23400 | TTF2 | 8458 | 204407_at | 0.4450 | 0.0000 | |
| GSE26886 | TTF2 | 8458 | 204407_at | 0.5463 | 0.0117 | |
| GSE29001 | TTF2 | 8458 | 204407_at | 0.6546 | 0.0286 | |
| GSE38129 | TTF2 | 8458 | 204407_at | 0.9651 | 0.0000 | |
| GSE45670 | TTF2 | 8458 | 204407_at | 0.5050 | 0.0138 | |
| GSE53622 | TTF2 | 8458 | 98456 | 0.4466 | 0.0000 | |
| GSE53624 | TTF2 | 8458 | 98456 | 0.8135 | 0.0000 | |
| GSE63941 | TTF2 | 8458 | 204407_at | 0.8061 | 0.0480 | |
| GSE77861 | TTF2 | 8458 | 204407_at | 0.2230 | 0.4142 | |
| GSE97050 | TTF2 | 8458 | A_33_P3256685 | 0.2348 | 0.4359 | |
| SRP007169 | TTF2 | 8458 | RNAseq | 1.9549 | 0.0000 | |
| SRP008496 | TTF2 | 8458 | RNAseq | 1.1596 | 0.0007 | |
| SRP064894 | TTF2 | 8458 | RNAseq | 0.3444 | 0.2504 | |
| SRP133303 | TTF2 | 8458 | RNAseq | 0.4752 | 0.0265 | |
| SRP159526 | TTF2 | 8458 | RNAseq | 0.1740 | 0.5910 | |
| SRP193095 | TTF2 | 8458 | RNAseq | 0.2635 | 0.0128 | |
| SRP219564 | TTF2 | 8458 | RNAseq | 0.3109 | 0.5520 | |
| TCGA | TTF2 | 8458 | RNAseq | 0.4223 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TTF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTF2 | 8458 | 0 | 8 | 22 | |
| GSE20123 | TTF2 | 8458 | 0 | 8 | 22 | |
| GSE43470 | TTF2 | 8458 | 0 | 5 | 38 | |
| GSE46452 | TTF2 | 8458 | 2 | 1 | 56 | |
| GSE47630 | TTF2 | 8458 | 9 | 5 | 26 | |
| GSE54993 | TTF2 | 8458 | 0 | 1 | 69 | |
| GSE54994 | TTF2 | 8458 | 10 | 2 | 41 | |
| GSE60625 | TTF2 | 8458 | 0 | 0 | 11 | |
| GSE74703 | TTF2 | 8458 | 0 | 4 | 32 | |
| GSE74704 | TTF2 | 8458 | 0 | 4 | 16 | |
| TCGA | TTF2 | 8458 | 15 | 28 | 53 |
Total number of gains: 36; Total number of losses: 66; Total Number of normals: 386.
Somatic mutations of TTF2:
Generating mutation plots.
Highly correlated genes for TTF2:
Showing top 20/1069 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTF2 | ARL13B | 0.758078 | 3 | 0 | 3 |
| TTF2 | SLC36A4 | 0.754839 | 3 | 0 | 3 |
| TTF2 | PHF6 | 0.73487 | 3 | 0 | 3 |
| TTF2 | LRRC58 | 0.730545 | 3 | 0 | 3 |
| TTF2 | SPPL2A | 0.726381 | 3 | 0 | 3 |
| TTF2 | SAMD1 | 0.725035 | 3 | 0 | 3 |
| TTF2 | CCDC82 | 0.719951 | 4 | 0 | 4 |
| TTF2 | SPRED1 | 0.711931 | 4 | 0 | 4 |
| TTF2 | TTC39C | 0.708971 | 3 | 0 | 3 |
| TTF2 | TCF20 | 0.706791 | 3 | 0 | 3 |
| TTF2 | MMS22L | 0.703627 | 3 | 0 | 3 |
| TTF2 | ANKRD50 | 0.703144 | 3 | 0 | 3 |
| TTF2 | CDK5RAP2 | 0.697102 | 3 | 0 | 3 |
| TTF2 | TBC1D2 | 0.695633 | 4 | 0 | 4 |
| TTF2 | SORD | 0.693248 | 5 | 0 | 4 |
| TTF2 | SLC25A24 | 0.690416 | 3 | 0 | 3 |
| TTF2 | RINT1 | 0.684088 | 4 | 0 | 3 |
| TTF2 | EWSR1 | 0.680729 | 5 | 0 | 5 |
| TTF2 | RAPGEF6 | 0.680563 | 4 | 0 | 3 |
| TTF2 | MAPK6 | 0.679886 | 4 | 0 | 3 |
For details and further investigation, click here
