| Full name: mitogen-activated protein kinase 6 | Alias Symbol: ERK3|p97MAPK|HsT17250 | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 5597 | HGNC ID: HGNC:6879 | Ensembl Gene: ENSG00000069956 | OMIM ID: 602904 |
| Drug and gene relationship at DGIdb | |||
Expression of MAPK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK6 | 5597 | 207121_s_at | 0.3449 | 0.6041 | |
| GSE20347 | MAPK6 | 5597 | 207121_s_at | 0.1956 | 0.1815 | |
| GSE23400 | MAPK6 | 5597 | 207121_s_at | 0.1548 | 0.1550 | |
| GSE26886 | MAPK6 | 5597 | 207121_s_at | 0.1204 | 0.6190 | |
| GSE29001 | MAPK6 | 5597 | 207121_s_at | -0.0543 | 0.8903 | |
| GSE38129 | MAPK6 | 5597 | 207121_s_at | 0.4204 | 0.0588 | |
| GSE45670 | MAPK6 | 5597 | 207121_s_at | 0.3468 | 0.0215 | |
| GSE53622 | MAPK6 | 5597 | 57970 | -0.0617 | 0.2838 | |
| GSE53624 | MAPK6 | 5597 | 57970 | -0.0041 | 0.9289 | |
| GSE63941 | MAPK6 | 5597 | 207121_s_at | 0.0650 | 0.9275 | |
| GSE77861 | MAPK6 | 5597 | 207121_s_at | 0.3828 | 0.1019 | |
| GSE97050 | MAPK6 | 5597 | A_24_P333663 | 0.3374 | 0.3115 | |
| SRP007169 | MAPK6 | 5597 | RNAseq | -1.0551 | 0.0035 | |
| SRP008496 | MAPK6 | 5597 | RNAseq | -0.9509 | 0.0001 | |
| SRP064894 | MAPK6 | 5597 | RNAseq | -0.4477 | 0.1891 | |
| SRP133303 | MAPK6 | 5597 | RNAseq | 0.5094 | 0.0329 | |
| SRP159526 | MAPK6 | 5597 | RNAseq | -0.1035 | 0.8415 | |
| SRP193095 | MAPK6 | 5597 | RNAseq | -0.0391 | 0.8393 | |
| SRP219564 | MAPK6 | 5597 | RNAseq | -0.3439 | 0.5796 | |
| TCGA | MAPK6 | 5597 | RNAseq | 0.2897 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MAPK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK6 | 5597 | 5 | 4 | 21 | |
| GSE20123 | MAPK6 | 5597 | 5 | 4 | 21 | |
| GSE43470 | MAPK6 | 5597 | 4 | 3 | 36 | |
| GSE46452 | MAPK6 | 5597 | 3 | 7 | 49 | |
| GSE47630 | MAPK6 | 5597 | 8 | 10 | 22 | |
| GSE54993 | MAPK6 | 5597 | 5 | 6 | 59 | |
| GSE54994 | MAPK6 | 5597 | 5 | 7 | 41 | |
| GSE60625 | MAPK6 | 5597 | 4 | 0 | 7 | |
| GSE74703 | MAPK6 | 5597 | 4 | 2 | 30 | |
| GSE74704 | MAPK6 | 5597 | 2 | 3 | 15 | |
| TCGA | MAPK6 | 5597 | 9 | 17 | 70 |
Total number of gains: 54; Total number of losses: 63; Total Number of normals: 371.
Somatic mutations of MAPK6:
Generating mutation plots.
Highly correlated genes for MAPK6:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK6 | PRELID1 | 0.833248 | 3 | 0 | 3 |
| MAPK6 | MRPL21 | 0.79042 | 3 | 0 | 3 |
| MAPK6 | PLEKHG1 | 0.78726 | 3 | 0 | 3 |
| MAPK6 | SUZ12 | 0.763386 | 3 | 0 | 3 |
| MAPK6 | ACTR2 | 0.753787 | 3 | 0 | 3 |
| MAPK6 | PSMG3 | 0.738925 | 3 | 0 | 3 |
| MAPK6 | C6orf141 | 0.719884 | 3 | 0 | 3 |
| MAPK6 | SUB1 | 0.718259 | 3 | 0 | 3 |
| MAPK6 | CBLC | 0.716382 | 4 | 0 | 4 |
| MAPK6 | CHST2 | 0.713608 | 4 | 0 | 3 |
| MAPK6 | ITGA3 | 0.712366 | 3 | 0 | 3 |
| MAPK6 | RANBP10 | 0.711834 | 3 | 0 | 3 |
| MAPK6 | ATP2B1 | 0.710579 | 3 | 0 | 3 |
| MAPK6 | BIRC6 | 0.705632 | 3 | 0 | 3 |
| MAPK6 | FAM83G | 0.702703 | 4 | 0 | 4 |
| MAPK6 | TAOK1 | 0.698884 | 3 | 0 | 3 |
| MAPK6 | KCNK6 | 0.696651 | 3 | 0 | 3 |
| MAPK6 | C1orf226 | 0.696291 | 3 | 0 | 3 |
| MAPK6 | RINT1 | 0.696166 | 4 | 0 | 3 |
| MAPK6 | COPB1 | 0.695747 | 5 | 0 | 4 |
For details and further investigation, click here
