| Full name: titin | Alias Symbol: CMPD4|FLJ32040|TMD|CMH9|LGMD2J|MYLK5 | ||
| Type: protein-coding gene | Cytoband: 2q31.2 | ||
| Entrez ID: 7273 | HGNC ID: HGNC:12403 | Ensembl Gene: ENSG00000155657 | OMIM ID: 188840 |
| Drug and gene relationship at DGIdb | |||
Expression of TTN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTN | 7273 | 208195_at | -0.0562 | 0.9416 | |
| GSE20347 | TTN | 7273 | 208195_at | -0.2418 | 0.0020 | |
| GSE23400 | TTN | 7273 | 208195_at | -0.0201 | 0.9177 | |
| GSE26886 | TTN | 7273 | 208195_at | -0.2329 | 0.0493 | |
| GSE29001 | TTN | 7273 | 208195_at | -0.2393 | 0.1462 | |
| GSE38129 | TTN | 7273 | 208195_at | -0.3643 | 0.0000 | |
| GSE53622 | TTN | 7273 | 39856 | -1.2818 | 0.0000 | |
| GSE53624 | TTN | 7273 | 39856 | -1.2500 | 0.0000 | |
| GSE77861 | TTN | 7273 | 208195_at | -0.2044 | 0.0465 | |
| GSE97050 | TTN | 7273 | A_33_P3329433 | -0.8159 | 0.1782 | |
| SRP007169 | TTN | 7273 | RNAseq | 2.0235 | 0.0000 | |
| SRP008496 | TTN | 7273 | RNAseq | 1.8411 | 0.0000 | |
| SRP064894 | TTN | 7273 | RNAseq | -0.4370 | 0.2208 | |
| SRP133303 | TTN | 7273 | RNAseq | -0.2859 | 0.2528 | |
| SRP159526 | TTN | 7273 | RNAseq | 0.1947 | 0.6823 | |
| SRP193095 | TTN | 7273 | RNAseq | 0.2722 | 0.1484 | |
| SRP219564 | TTN | 7273 | RNAseq | -0.2059 | 0.5757 | |
| TCGA | TTN | 7273 | RNAseq | -0.1891 | 0.1598 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by TTN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTN | 7273 | 7 | 0 | 23 | |
| GSE20123 | TTN | 7273 | 7 | 0 | 23 | |
| GSE43470 | TTN | 7273 | 5 | 1 | 37 | |
| GSE46452 | TTN | 7273 | 1 | 4 | 54 | |
| GSE47630 | TTN | 7273 | 4 | 4 | 32 | |
| GSE54993 | TTN | 7273 | 0 | 5 | 65 | |
| GSE54994 | TTN | 7273 | 11 | 4 | 38 | |
| GSE60625 | TTN | 7273 | 0 | 3 | 8 | |
| GSE74703 | TTN | 7273 | 4 | 1 | 31 | |
| GSE74704 | TTN | 7273 | 4 | 0 | 16 | |
| TCGA | TTN | 7273 | 27 | 6 | 63 |
Total number of gains: 70; Total number of losses: 28; Total Number of normals: 390.
Somatic mutations of TTN:
Generating mutation plots.
Highly correlated genes for TTN:
Showing top 20/917 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTN | ANGPTL6 | 0.744458 | 3 | 0 | 3 |
| TTN | NFIA | 0.743822 | 4 | 0 | 4 |
| TTN | MAP1A | 0.738481 | 3 | 0 | 3 |
| TTN | CD226 | 0.736335 | 3 | 0 | 3 |
| TTN | FRAS1 | 0.722403 | 4 | 0 | 4 |
| TTN | KDM4B | 0.718605 | 3 | 0 | 3 |
| TTN | CISH | 0.715337 | 5 | 0 | 5 |
| TTN | ANGPTL1 | 0.707006 | 3 | 0 | 3 |
| TTN | SH2B1 | 0.706821 | 3 | 0 | 3 |
| TTN | SLN | 0.704447 | 3 | 0 | 3 |
| TTN | CCIN | 0.703163 | 5 | 0 | 5 |
| TTN | RPL14 | 0.702196 | 4 | 0 | 4 |
| TTN | CKM | 0.701795 | 5 | 0 | 4 |
| TTN | TMOD2 | 0.701664 | 3 | 0 | 3 |
| TTN | WDR37 | 0.701628 | 3 | 0 | 3 |
| TTN | HAVCR2 | 0.693561 | 3 | 0 | 3 |
| TTN | XKR6 | 0.69101 | 3 | 0 | 3 |
| TTN | OXNAD1 | 0.685656 | 4 | 0 | 3 |
| TTN | TAB1 | 0.685278 | 3 | 0 | 3 |
| TTN | MTA3 | 0.675964 | 3 | 0 | 3 |
For details and further investigation, click here
