| Full name: tumor suppressor candidate 3 | Alias Symbol: MGC13453|N33|OST3A|MRT7|MagT2|SLC58A2 | ||
| Type: protein-coding gene | Cytoband: 8p22 | ||
| Entrez ID: 7991 | HGNC ID: HGNC:30242 | Ensembl Gene: ENSG00000104723 | OMIM ID: 601385 |
| Drug and gene relationship at DGIdb | |||
Expression of TUSC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TUSC3 | 7991 | 213423_x_at | 1.1580 | 0.1282 | |
| GSE20347 | TUSC3 | 7991 | 213423_x_at | 1.2460 | 0.0121 | |
| GSE23400 | TUSC3 | 7991 | 213423_x_at | 1.3680 | 0.0000 | |
| GSE26886 | TUSC3 | 7991 | 213423_x_at | 0.7360 | 0.2486 | |
| GSE29001 | TUSC3 | 7991 | 213423_x_at | 1.0172 | 0.0745 | |
| GSE38129 | TUSC3 | 7991 | 213423_x_at | 1.2986 | 0.0001 | |
| GSE45670 | TUSC3 | 7991 | 213423_x_at | 1.0983 | 0.0011 | |
| GSE53622 | TUSC3 | 7991 | 70298 | 1.3868 | 0.0000 | |
| GSE53624 | TUSC3 | 7991 | 70298 | 1.2676 | 0.0000 | |
| GSE63941 | TUSC3 | 7991 | 213423_x_at | -1.2645 | 0.3731 | |
| GSE77861 | TUSC3 | 7991 | 213423_x_at | 1.0441 | 0.1007 | |
| GSE97050 | TUSC3 | 7991 | A_24_P95154 | 0.7629 | 0.1594 | |
| SRP007169 | TUSC3 | 7991 | RNAseq | 1.5903 | 0.0001 | |
| SRP008496 | TUSC3 | 7991 | RNAseq | 1.8897 | 0.0000 | |
| SRP064894 | TUSC3 | 7991 | RNAseq | 1.3384 | 0.0000 | |
| SRP133303 | TUSC3 | 7991 | RNAseq | 0.9038 | 0.0348 | |
| SRP159526 | TUSC3 | 7991 | RNAseq | 1.3849 | 0.0003 | |
| SRP193095 | TUSC3 | 7991 | RNAseq | 0.6427 | 0.0076 | |
| SRP219564 | TUSC3 | 7991 | RNAseq | 0.9628 | 0.0299 | |
| TCGA | TUSC3 | 7991 | RNAseq | 0.5376 | 0.0001 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by TUSC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TUSC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TUSC3 | 7991 | 4 | 11 | 15 | |
| GSE20123 | TUSC3 | 7991 | 4 | 11 | 15 | |
| GSE43470 | TUSC3 | 7991 | 4 | 8 | 31 | |
| GSE46452 | TUSC3 | 7991 | 13 | 14 | 32 | |
| GSE47630 | TUSC3 | 7991 | 10 | 8 | 22 | |
| GSE54993 | TUSC3 | 7991 | 3 | 13 | 54 | |
| GSE54994 | TUSC3 | 7991 | 8 | 18 | 27 | |
| GSE60625 | TUSC3 | 7991 | 3 | 0 | 8 | |
| GSE74703 | TUSC3 | 7991 | 4 | 7 | 25 | |
| GSE74704 | TUSC3 | 7991 | 3 | 7 | 10 | |
| TCGA | TUSC3 | 7991 | 12 | 41 | 43 |
Total number of gains: 68; Total number of losses: 138; Total Number of normals: 282.
Somatic mutations of TUSC3:
Generating mutation plots.
Highly correlated genes for TUSC3:
Showing top 20/1186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TUSC3 | SNAP47 | 0.777461 | 3 | 0 | 3 |
| TUSC3 | MMS22L | 0.744664 | 3 | 0 | 3 |
| TUSC3 | PYCR2 | 0.73855 | 3 | 0 | 3 |
| TUSC3 | FMNL2 | 0.7344 | 6 | 0 | 6 |
| TUSC3 | TTYH3 | 0.729068 | 5 | 0 | 5 |
| TUSC3 | SLCO3A1 | 0.716557 | 3 | 0 | 3 |
| TUSC3 | KRTDAP | 0.709387 | 3 | 0 | 3 |
| TUSC3 | NF1 | 0.707792 | 3 | 0 | 3 |
| TUSC3 | NOP56 | 0.705157 | 3 | 0 | 3 |
| TUSC3 | FANCB | 0.703905 | 4 | 0 | 4 |
| TUSC3 | TMEM138 | 0.70322 | 6 | 0 | 6 |
| TUSC3 | ZBTB9 | 0.702089 | 3 | 0 | 3 |
| TUSC3 | WDR54 | 0.700077 | 6 | 0 | 5 |
| TUSC3 | RRP36 | 0.699731 | 3 | 0 | 3 |
| TUSC3 | MRPL11 | 0.699437 | 4 | 0 | 4 |
| TUSC3 | RAB34 | 0.698682 | 3 | 0 | 3 |
| TUSC3 | FLVCR1 | 0.698064 | 5 | 0 | 4 |
| TUSC3 | ANAPC1 | 0.695651 | 3 | 0 | 3 |
| TUSC3 | C12orf75 | 0.694921 | 6 | 0 | 6 |
| TUSC3 | OTULIN | 0.691833 | 3 | 0 | 3 |
For details and further investigation, click here
