| Full name: TXK tyrosine kinase | Alias Symbol: TKL|PSCTK5|BTKL|RLK | ||
| Type: protein-coding gene | Cytoband: 4p12 | ||
| Entrez ID: 7294 | HGNC ID: HGNC:12434 | Ensembl Gene: ENSG00000074966 | OMIM ID: 600058 |
| Drug and gene relationship at DGIdb | |||
TXK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04670 | Leukocyte transendothelial migration |
Expression of TXK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXK | 7294 | 206828_at | -0.1711 | 0.8373 | |
| GSE20347 | TXK | 7294 | 206828_at | -0.1356 | 0.0470 | |
| GSE23400 | TXK | 7294 | 206828_at | -0.1255 | 0.0000 | |
| GSE26886 | TXK | 7294 | 206828_at | -0.6668 | 0.0001 | |
| GSE29001 | TXK | 7294 | 206828_at | -0.4480 | 0.0060 | |
| GSE38129 | TXK | 7294 | 206828_at | -0.1686 | 0.0022 | |
| GSE45670 | TXK | 7294 | 206828_at | -0.0724 | 0.7918 | |
| GSE53622 | TXK | 7294 | 23400 | -0.9598 | 0.0000 | |
| GSE53624 | TXK | 7294 | 23400 | -1.4894 | 0.0000 | |
| GSE63941 | TXK | 7294 | 206828_at | 0.2550 | 0.5644 | |
| GSE77861 | TXK | 7294 | 206828_at | -0.0662 | 0.4376 | |
| SRP133303 | TXK | 7294 | RNAseq | -1.0599 | 0.0000 | |
| SRP159526 | TXK | 7294 | RNAseq | -2.0874 | 0.0053 | |
| SRP193095 | TXK | 7294 | RNAseq | -1.1899 | 0.0000 | |
| SRP219564 | TXK | 7294 | RNAseq | -1.4943 | 0.0201 | |
| TCGA | TXK | 7294 | RNAseq | -0.4407 | 0.2233 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TXK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXK | 7294 | 1 | 15 | 14 | |
| GSE20123 | TXK | 7294 | 1 | 15 | 14 | |
| GSE43470 | TXK | 7294 | 0 | 13 | 30 | |
| GSE46452 | TXK | 7294 | 1 | 37 | 21 | |
| GSE47630 | TXK | 7294 | 1 | 18 | 21 | |
| GSE54993 | TXK | 7294 | 7 | 0 | 63 | |
| GSE54994 | TXK | 7294 | 4 | 9 | 40 | |
| GSE60625 | TXK | 7294 | 0 | 0 | 11 | |
| GSE74703 | TXK | 7294 | 0 | 11 | 25 | |
| GSE74704 | TXK | 7294 | 0 | 9 | 11 | |
| TCGA | TXK | 7294 | 21 | 34 | 41 |
Total number of gains: 36; Total number of losses: 161; Total Number of normals: 291.
Somatic mutations of TXK:
Generating mutation plots.
Highly correlated genes for TXK:
Showing top 20/811 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXK | LINC01215 | 0.707239 | 3 | 0 | 3 |
| TXK | TLR10 | 0.700253 | 3 | 0 | 3 |
| TXK | ZC3H12D | 0.696793 | 3 | 0 | 3 |
| TXK | FCHO2 | 0.694939 | 5 | 0 | 5 |
| TXK | GIMAP7 | 0.694321 | 3 | 0 | 3 |
| TXK | TMEM154 | 0.680023 | 5 | 0 | 5 |
| TXK | SMIM5 | 0.673476 | 6 | 0 | 6 |
| TXK | PGM2 | 0.671504 | 4 | 0 | 4 |
| TXK | C5orf66-AS1 | 0.671264 | 5 | 0 | 5 |
| TXK | SPINK7 | 0.669414 | 5 | 0 | 5 |
| TXK | GPR18 | 0.668468 | 5 | 0 | 5 |
| TXK | CTTNBP2 | 0.668212 | 5 | 0 | 5 |
| TXK | VSIG10L | 0.661592 | 5 | 0 | 5 |
| TXK | ST6GALNAC1 | 0.658948 | 5 | 0 | 5 |
| TXK | CAPN14 | 0.657166 | 5 | 0 | 5 |
| TXK | BNIPL | 0.656849 | 5 | 0 | 5 |
| TXK | FAM214A | 0.656631 | 6 | 0 | 5 |
| TXK | TRNP1 | 0.656131 | 5 | 0 | 4 |
| TXK | KLB | 0.656119 | 5 | 0 | 4 |
| TXK | PRSS27 | 0.652033 | 6 | 0 | 6 |
For details and further investigation, click here
