| Full name: thioredoxin reductase 1 | Alias Symbol: TXNR|GRIM-12|Trxr1 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 7296 | HGNC ID: HGNC:12437 | Ensembl Gene: ENSG00000198431 | OMIM ID: 601112 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TXNRD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXNRD1 | 7296 | 201266_at | 0.6671 | 0.4437 | |
| GSE20347 | TXNRD1 | 7296 | 201266_at | 1.9423 | 0.0000 | |
| GSE23400 | TXNRD1 | 7296 | 201266_at | 0.9991 | 0.0000 | |
| GSE26886 | TXNRD1 | 7296 | 201266_at | 1.6242 | 0.0004 | |
| GSE29001 | TXNRD1 | 7296 | 201266_at | 0.8577 | 0.0559 | |
| GSE38129 | TXNRD1 | 7296 | 201266_at | 1.6745 | 0.0000 | |
| GSE45670 | TXNRD1 | 7296 | 201266_at | 0.7469 | 0.1794 | |
| GSE53622 | TXNRD1 | 7296 | 88232 | 1.3725 | 0.0000 | |
| GSE53624 | TXNRD1 | 7296 | 88232 | 1.5307 | 0.0000 | |
| GSE63941 | TXNRD1 | 7296 | 201266_at | -1.3785 | 0.0680 | |
| GSE77861 | TXNRD1 | 7296 | 201266_at | 2.4357 | 0.0022 | |
| GSE97050 | TXNRD1 | 7296 | A_33_P3351120 | -0.0077 | 0.9805 | |
| SRP007169 | TXNRD1 | 7296 | RNAseq | 2.9375 | 0.0000 | |
| SRP008496 | TXNRD1 | 7296 | RNAseq | 2.9431 | 0.0000 | |
| SRP064894 | TXNRD1 | 7296 | RNAseq | 0.2528 | 0.3850 | |
| SRP133303 | TXNRD1 | 7296 | RNAseq | 1.2666 | 0.0000 | |
| SRP159526 | TXNRD1 | 7296 | RNAseq | 2.8576 | 0.0000 | |
| SRP193095 | TXNRD1 | 7296 | RNAseq | 1.7342 | 0.0000 | |
| SRP219564 | TXNRD1 | 7296 | RNAseq | 0.4203 | 0.5574 | |
| TCGA | TXNRD1 | 7296 | RNAseq | 0.0917 | 0.4199 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by TXNRD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXNRD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXNRD1 | 7296 | 4 | 2 | 24 | |
| GSE20123 | TXNRD1 | 7296 | 4 | 2 | 24 | |
| GSE43470 | TXNRD1 | 7296 | 2 | 0 | 41 | |
| GSE46452 | TXNRD1 | 7296 | 9 | 1 | 49 | |
| GSE47630 | TXNRD1 | 7296 | 9 | 1 | 30 | |
| GSE54993 | TXNRD1 | 7296 | 0 | 5 | 65 | |
| GSE54994 | TXNRD1 | 7296 | 4 | 2 | 47 | |
| GSE60625 | TXNRD1 | 7296 | 0 | 0 | 11 | |
| GSE74703 | TXNRD1 | 7296 | 2 | 0 | 34 | |
| GSE74704 | TXNRD1 | 7296 | 1 | 2 | 17 | |
| TCGA | TXNRD1 | 7296 | 20 | 11 | 65 |
Total number of gains: 55; Total number of losses: 26; Total Number of normals: 407.
Somatic mutations of TXNRD1:
Generating mutation plots.
Highly correlated genes for TXNRD1:
Showing top 20/1328 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXNRD1 | MRPS5 | 0.793906 | 3 | 0 | 3 |
| TXNRD1 | CLIP3 | 0.789687 | 3 | 0 | 3 |
| TXNRD1 | COA6 | 0.772943 | 6 | 0 | 6 |
| TXNRD1 | FADS1 | 0.766334 | 4 | 0 | 4 |
| TXNRD1 | UBE3A | 0.754165 | 3 | 0 | 3 |
| TXNRD1 | SGTB | 0.749465 | 4 | 0 | 4 |
| TXNRD1 | ABCC1 | 0.7471 | 13 | 0 | 13 |
| TXNRD1 | GLI2 | 0.736381 | 11 | 0 | 10 |
| TXNRD1 | CABYR | 0.735812 | 11 | 0 | 11 |
| TXNRD1 | BTBD6 | 0.729405 | 3 | 0 | 3 |
| TXNRD1 | STARD7 | 0.725309 | 12 | 0 | 11 |
| TXNRD1 | AKR1B1 | 0.721756 | 12 | 0 | 11 |
| TXNRD1 | PTDSS2 | 0.716603 | 3 | 0 | 3 |
| TXNRD1 | FTL | 0.716325 | 12 | 0 | 12 |
| TXNRD1 | WDR81 | 0.716232 | 4 | 0 | 3 |
| TXNRD1 | GOPC | 0.715235 | 3 | 0 | 3 |
| TXNRD1 | AVEN | 0.714565 | 3 | 0 | 3 |
| TXNRD1 | EID3 | 0.712849 | 9 | 0 | 9 |
| TXNRD1 | C18orf54 | 0.709671 | 4 | 0 | 4 |
| TXNRD1 | PRPSAP2 | 0.709598 | 9 | 0 | 9 |
For details and further investigation, click here
