| Full name: ATP binding cassette subfamily C member 1 | Alias Symbol: GS-X | ||
| Type: protein-coding gene | Cytoband: 16p13.11 | ||
| Entrez ID: 4363 | HGNC ID: HGNC:51 | Ensembl Gene: ENSG00000103222 | OMIM ID: 158343 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ABCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCC1 | 4363 | 202804_at | 0.6658 | 0.4184 | |
| GSE20347 | ABCC1 | 4363 | 202804_at | 0.7885 | 0.0050 | |
| GSE23400 | ABCC1 | 4363 | 202804_at | 0.5982 | 0.0000 | |
| GSE26886 | ABCC1 | 4363 | 202804_at | 1.8129 | 0.0000 | |
| GSE29001 | ABCC1 | 4363 | 202804_at | 0.4894 | 0.1365 | |
| GSE38129 | ABCC1 | 4363 | 202804_at | 0.8696 | 0.0003 | |
| GSE45670 | ABCC1 | 4363 | 202804_at | 0.3557 | 0.3915 | |
| GSE53622 | ABCC1 | 4363 | 23592 | 0.6744 | 0.0000 | |
| GSE53624 | ABCC1 | 4363 | 23592 | 0.8149 | 0.0000 | |
| GSE63941 | ABCC1 | 4363 | 202804_at | -1.5160 | 0.0014 | |
| GSE77861 | ABCC1 | 4363 | 202804_at | 1.6492 | 0.0032 | |
| GSE97050 | ABCC1 | 4363 | A_24_P227831 | -0.1569 | 0.6847 | |
| SRP007169 | ABCC1 | 4363 | RNAseq | 0.9392 | 0.0159 | |
| SRP008496 | ABCC1 | 4363 | RNAseq | 1.1912 | 0.0007 | |
| SRP064894 | ABCC1 | 4363 | RNAseq | -0.0061 | 0.9797 | |
| SRP133303 | ABCC1 | 4363 | RNAseq | 0.5354 | 0.0006 | |
| SRP159526 | ABCC1 | 4363 | RNAseq | 2.0124 | 0.0000 | |
| SRP193095 | ABCC1 | 4363 | RNAseq | 1.1025 | 0.0000 | |
| SRP219564 | ABCC1 | 4363 | RNAseq | 0.4594 | 0.3382 | |
| TCGA | ABCC1 | 4363 | RNAseq | 0.2534 | 0.0029 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by ABCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCC1 | 4363 | 5 | 4 | 21 | |
| GSE20123 | ABCC1 | 4363 | 5 | 3 | 22 | |
| GSE43470 | ABCC1 | 4363 | 3 | 3 | 37 | |
| GSE46452 | ABCC1 | 4363 | 38 | 1 | 20 | |
| GSE47630 | ABCC1 | 4363 | 11 | 6 | 23 | |
| GSE54993 | ABCC1 | 4363 | 3 | 5 | 62 | |
| GSE54994 | ABCC1 | 4363 | 4 | 10 | 39 | |
| GSE60625 | ABCC1 | 4363 | 4 | 1 | 6 | |
| GSE74703 | ABCC1 | 4363 | 3 | 2 | 31 | |
| GSE74704 | ABCC1 | 4363 | 2 | 1 | 17 | |
| TCGA | ABCC1 | 4363 | 20 | 12 | 64 |
Total number of gains: 98; Total number of losses: 48; Total Number of normals: 342.
Somatic mutations of ABCC1:
Generating mutation plots.
Highly correlated genes for ABCC1:
Showing top 20/795 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCC1 | CLIP3 | 0.79445 | 3 | 0 | 3 |
| ABCC1 | PLEKHA3 | 0.781744 | 3 | 0 | 3 |
| ABCC1 | FOXF1 | 0.760095 | 3 | 0 | 3 |
| ABCC1 | AP2B1 | 0.756906 | 3 | 0 | 3 |
| ABCC1 | PAMR1 | 0.752981 | 3 | 0 | 3 |
| ABCC1 | TXNRD1 | 0.7471 | 13 | 0 | 13 |
| ABCC1 | SGTB | 0.744655 | 4 | 0 | 4 |
| ABCC1 | FAM89B | 0.744209 | 3 | 0 | 3 |
| ABCC1 | SMCR8 | 0.738863 | 3 | 0 | 3 |
| ABCC1 | MSTO1 | 0.734625 | 3 | 0 | 3 |
| ABCC1 | GLI2 | 0.733413 | 11 | 0 | 11 |
| ABCC1 | CD44 | 0.731814 | 4 | 0 | 4 |
| ABCC1 | FOXN3 | 0.713829 | 3 | 0 | 3 |
| ABCC1 | ZNF567 | 0.713391 | 3 | 0 | 3 |
| ABCC1 | MRPS5 | 0.711249 | 3 | 0 | 3 |
| ABCC1 | FAM20C | 0.710718 | 3 | 0 | 3 |
| ABCC1 | PIEZO1 | 0.709814 | 3 | 0 | 3 |
| ABCC1 | DLX6-AS1 | 0.708492 | 4 | 0 | 4 |
| ABCC1 | RHOBTB2 | 0.708335 | 3 | 0 | 3 |
| ABCC1 | A1BG | 0.705946 | 3 | 0 | 3 |
For details and further investigation, click here
