| Full name: ferritin light chain | Alias Symbol: MGC71996|NBIA3 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 2512 | HGNC ID: HGNC:3999 | Ensembl Gene: ENSG00000087086 | OMIM ID: 134790 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FTL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FTL | 2512 | 212788_x_at | 0.5192 | 0.0967 | |
| GSE20347 | FTL | 2512 | 212788_x_at | 1.0941 | 0.0000 | |
| GSE23400 | FTL | 2512 | 212788_x_at | 0.7504 | 0.0000 | |
| GSE26886 | FTL | 2512 | 212788_x_at | 1.2100 | 0.0000 | |
| GSE29001 | FTL | 2512 | 212788_x_at | 0.4101 | 0.3481 | |
| GSE38129 | FTL | 2512 | 212788_x_at | 0.8813 | 0.0000 | |
| GSE45670 | FTL | 2512 | 212788_x_at | 0.1324 | 0.5939 | |
| GSE53622 | FTL | 2512 | 105713 | 1.3791 | 0.0000 | |
| GSE53624 | FTL | 2512 | 17766 | 1.6849 | 0.0000 | |
| GSE63941 | FTL | 2512 | 212788_x_at | -1.0696 | 0.0412 | |
| GSE77861 | FTL | 2512 | 212788_x_at | 1.0059 | 0.0088 | |
| GSE97050 | FTL | 2512 | A_23_P50504 | 0.8242 | 0.1015 | |
| SRP007169 | FTL | 2512 | RNAseq | 1.2365 | 0.0208 | |
| SRP008496 | FTL | 2512 | RNAseq | 1.2381 | 0.0026 | |
| SRP064894 | FTL | 2512 | RNAseq | 1.1108 | 0.0018 | |
| SRP133303 | FTL | 2512 | RNAseq | 0.8607 | 0.0001 | |
| SRP159526 | FTL | 2512 | RNAseq | 1.6799 | 0.0001 | |
| SRP193095 | FTL | 2512 | RNAseq | 1.0817 | 0.0000 | |
| SRP219564 | FTL | 2512 | RNAseq | 1.1792 | 0.0901 | |
| TCGA | FTL | 2512 | RNAseq | 0.0685 | 0.3060 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by FTL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FTL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FTL | 2512 | 4 | 4 | 22 | |
| GSE20123 | FTL | 2512 | 4 | 3 | 23 | |
| GSE43470 | FTL | 2512 | 4 | 10 | 29 | |
| GSE46452 | FTL | 2512 | 45 | 1 | 13 | |
| GSE47630 | FTL | 2512 | 9 | 6 | 25 | |
| GSE54993 | FTL | 2512 | 17 | 4 | 49 | |
| GSE54994 | FTL | 2512 | 4 | 14 | 35 | |
| GSE60625 | FTL | 2512 | 9 | 0 | 2 | |
| GSE74703 | FTL | 2512 | 4 | 7 | 25 | |
| GSE74704 | FTL | 2512 | 4 | 1 | 15 | |
| TCGA | FTL | 2512 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of FTL:
Generating mutation plots.
Highly correlated genes for FTL:
Showing top 20/1081 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FTL | MFAP2 | 0.739705 | 11 | 0 | 10 |
| FTL | CDH11 | 0.72029 | 12 | 0 | 12 |
| FTL | TXNRD1 | 0.716325 | 12 | 0 | 12 |
| FTL | SPP1 | 0.711938 | 12 | 0 | 11 |
| FTL | VCAN | 0.708962 | 12 | 0 | 11 |
| FTL | MARCKSL1 | 0.705956 | 10 | 0 | 9 |
| FTL | POSTN | 0.702657 | 12 | 0 | 10 |
| FTL | COL3A1 | 0.701725 | 12 | 0 | 12 |
| FTL | LPCAT1 | 0.7014 | 9 | 0 | 9 |
| FTL | THBS2 | 0.695955 | 9 | 0 | 9 |
| FTL | SERPINH1 | 0.692964 | 11 | 0 | 10 |
| FTL | SULF1 | 0.692503 | 12 | 0 | 10 |
| FTL | BID | 0.691584 | 10 | 0 | 10 |
| FTL | SSR2 | 0.689021 | 12 | 0 | 12 |
| FTL | SDK1 | 0.687575 | 6 | 0 | 6 |
| FTL | IFITM1 | 0.685064 | 7 | 0 | 7 |
| FTL | PDIA5 | 0.684524 | 3 | 0 | 3 |
| FTL | COL6A3 | 0.683783 | 12 | 0 | 11 |
| FTL | DESI2 | 0.680644 | 11 | 0 | 11 |
| FTL | DNLZ | 0.678415 | 3 | 0 | 3 |
For details and further investigation, click here
